Melatonin: Physiological effects in humans

Neurochirurgie

Volumn 61, Issue 2-3, 2015, Pages 77-84

  Claustrat, B ^a   Leston, J ^b  

^a HOSPICES CIVILS DE LYON   (France)

^b HÔPITAL NEUROLOGIQUE   (France)

Author keywords

Circadian rhythms; Human; Melatonin; Pathophysiology; Physiology

Indexed keywords

MELATONIN; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR;

ANTIOXIDANT ACTIVITY; CIRCADIAN RHYTHM; CORE TEMPERATURE; DOSE RESPONSE; DRUG MEGADOSE; HORMONAL REGULATION; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE METABOLISM; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; LIGHT DARK CYCLE; NERVE DEGENERATION; NONHUMAN; PHYSIOLOGY; PROTEIN LOCALIZATION; REVIEW; SEASONAL VARIATION; SLEEP WAKING CYCLE; ANIMAL; BRAIN; DRUG EFFECTS; LIGHT; METABOLISM; SEASON; SLEEP;

ANIMALS; BRAIN; CIRCADIAN RHYTHM; HUMANS; LIGHT; MELATONIN; SEASONS; SLEEP;

EID: 84929704840     PISSN: 00283770     EISSN: 17730619     Source Type: Journal    
DOI: 10.1016/j.neuchi.2015.03.002     Document Type: Review

References (81)

1. Lerner A.B., Case J.D., Takahashi Y., Lee T.H., Mori V. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J Am Chem Soc 1958, 80:2587.
2. Liu C., Fukuhara C., Wessel J.H., Iuvone P.M., Tosini G. Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissection. Cell Tissue Res 2004, 315:197-201.
3. Bubenik G.A. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci 2002, 47:2336-2348.
4. Slominski A., Pisarchik A., Semak I., Sweatman T., Wortsman J., Szczesniewski A., et al. Serotoninergic and melatoninergic systems are fully expressed in human skin. Faseb J 2002, 16:896-898.
5. Champier J., Claustrat B., Besançon R., Eymin C., Killer C., Jouvet A., et al. Evidence for tryptophan hydroxylase and hydroxy-indol-O-methyl-transferase mRNAs in human blood platelets. Life Sci 1997, 60:2191-2197.
6. Cardinali D.P., Ladizesky M.G., Boggio V., Cutrera R.A., Mautalen C. Melatonin effects on bone: experimental facts and clinical perspectives. J Pineal Res 2003, 34:81-87.
7. Hardeland R. Melatonin and 5 methoxytryptamine in non-metazoans. Reprod Nutr Dev 1999, 39:399-408.
8. Tan D.X., Manchester L.C., Hardeland R., Lopez-Burillo S., Mayo J.C., Sainz R.M., et al. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 2003, 34:75-78.
9. Bernard M., Guerlotté J., Grève P., Gréchez-Cassiau A., Iuvone M.P., Zatz M., et al. Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina. Reprod Nutr Dev 1999, 39:325-334.
10. Zimmermann R.C., McDougle C.J., Schumacher M., Olcese J., Mason J.W., Heninger G.R., et al. Effects of acute tryptophan depletion on nocturnal melatonin secretion in humans. J Clin Endocrinol Metab 1993, 76:1160-1164.
11. Fournier I., Ploye F., Cottet-Emard J.M., Brun J., Claustrat B. Folate deficiency alters melatonin secretion in rats. J Nutr 2002, 132:2781-2784.
12. Munoz-Hoyos A., Amoros-Rodriguez I., Molina-Carballo A., Uberos-Fernández J., Acuña-Castroviejo D. Pineal response after pyridoxine test in children. J Neural Transm 1996, 103:833-842.
13. Luboshitzky R., Ophir U., Nave R., Epstein R., Shen-Orr Z., Herer P. The effect of pyridoxine administration on melatonin secretion in normal men. Neuroendocrinol Lett 2002, 23:213-217.
14. Pardridge W.M., Mietus L.J. Transport of albumin-bound melatonin through the blood-brain barrier. J Neurochem 1980, 34:1761-1763.
15. Reiter R.J. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 1991, 12:151-180.
16. 11C Melatonin in humans. Nucl Med Biol 1991, 18:357-362.
17. Waldhauser F., Ehrhart B., Förster E. Clinical aspects of the melatonin action: impact of development, aging, and puberty, involvement of melatonin in psychiatric disease and importance of neuroimmunoendocrine interactions. Experientia 1993, 49:671-681.
18. Waldhauser F., Boepple P.A., Schemper M., Mansfield M.J., Crowley W.F. Serum melatonin in central precocious puberty is lower than in age-matched prepubertal children. J Clin Endocrinol Metab 1991, 73:793-796.
19. Berga S.L., Yen S.S.C. Circadian pattern of plasma melatonin concentrations during four phases of the human menstrual cycle. Neuroendocrinol 1990, 51:606-612.
20. Iguchi H., Kato K.I., Ibayashi H. Age-dependent reduction in serum melatonin concentrations in healthy human subjects. J Clin Endocrinol Metab 1982, 55:27-29.
21. Haimov I., Laudon M., Zisapel N., Souroujon M., Nof D., Shlitner A., et al. Sleep disorders and melatonin rhythms in elderly people. Br Med J 1994, 309:167.
22. Cardinali D.P. Melatonin. A mammalian pineal hormone. Endocr Rev 1981, 2(3):327-346.
23. Cardinali D.P., Pevet P. Basic aspects of melatonin action. Sleep Med Rev 1998, 2:175-190.
24. Hirata F., Hayaishi O., Tokuyama T., Senoh S. In vitro and in vivo formation of two new metabolites of Melatonin. J Biol Chem 1974, 249:1311-1313.
25. Gunes A., Dahl M.L. Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms. Pharmacogenomics 2008, 9:625-637. [Review].
26. Härtter S., Korhonen T., Lundgren S., Rane A., Tolonen A., Turpeinen M., et al. Effect of caffeine intake 12 or 24hours prior to melatonin intake and CYP1A2*1F polymorphism on CYP1A2 phenotyping by melatonin. Basic Clin Pharmacol Toxicol 2006, 99:300-304.
27. Ursing C., von Bahr C., Brismar K., Röjdmark S. Influence of cigarette smoking on melatonin levels in man. Eur J Clin Pharmacol 2005, 61:197-201.
28. Francis P.L., Leone A.M., Young I.M., Stovell P., Silman R.E. Gas chromatographic-mass spectrometric assay for 6-hydroxymelatonin sulfate and 6-hydroxymelatonin glucuronide in urine. Clin Chem 1987, 33:453-457.
29. Arendt J., Bojkowski C., Franey C., Wright J., Marks V. Immunoassay of 6-hydroxymelatonin sulfate in human plasma and urine: abolition of the urinary 24-hour rhythm with Atenolol. J Clin Endocrinol Metab 1985, 60:1166-1173.
30. Edgar D.M., Dement W.C., Fuller C.A. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J Neurosci 1993, 13:1065-1079.
31. Moore R.Y. The fourth C.U. Ariens Kappers lecture. The organization of the human circadian timing system. Prog Brain Res 1992, 93:99-115.
32. Cohen R.A., Albers H.E. Disruption of human circadian and cognitive regulation following a discrete hypothalamic lesion: a case study. Neurology 1991, 41:726-729.
33. Lewy A.J., Wehr T.A., Goodwin F.K., Newsome D.A., Markey S.P. Light suppresses melatonin secretion in humans. Science 1980, 210:1267-1269.
34. Bojkowski C.J., Aldhous M.E., English J., Franey C., Poulton A.L., Skene D.J., et al. Suppression of nocturnal plasma melatonin and 6-sulphatoxymelatonin by bright and dim light in man. Horm Metab Res 1987, 19:437-440.
35. Thapan K., Arendt J., Skene D. An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol 2001, 535:261-267.
36. Brainard G.C., Hanifin J.P., Greeson J.M., Byrne B., Glickman G., Gerne R.E., et al. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J Neurosci 2001, 21:6405-6412.
37. Chellappa S.L., Steiner R., Blattner P., Oelhafen P., Götz T., Cajochen C. Non-visual effects of light on melatonin, alertness and cognitive performance: can blue-enriched light keep us alert?. Prog Brain Res 2011, 190:119-133.
38. Berson D.M., Dunn F.A., Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science 2002, 295:1070-1073.
39. Hughes S., Hankins M.W., Foster R.G., Peirson S.N. Melanopsin phototransduction: slowly emerging from the dark. Prog Brain Res 2012, 199:19-40.
40. Moore R.Y. The innervation of the mammalian pineal gland. The pineal and reproduction 1978, 1-29. Karger, Basel. R.J. Reiter (Ed.).
41. Moller M., Baeres F.M. The anatomy and innervation of the mammalian pineal gland. Cell Tissue Res 2002, 309:139-150.
42. Monteleone P., Tortorella A., Borriello R., Natale M., Cassandro P., Maj M. Suppression of nocturnal plasma melatonin levels by evening administration of sodium valproate in healthy humans. Biol Psychiatry 1997, 41:336-341.
43. Warman G.R., Tripp H.M., Warman V.L., Arendt J. Circadian neuroendocrine physiology and electromagnetic field studies: precautions and complexities. Radiat Prot Dosimetry 2003, 106:369-373.
44. Lewy A.J., Sack R.L. The dim light melatonin onset as a marker for circadian phase position. Chronobiol Int 1989, 6:93-102.
45. Chazot G., Claustrat B., Broussolle E., Lapras C. Headache and depression: recurrent symptoms in adult pinealectomized patients. Headache and depression: serotonin pathways as a common clue 1991, 299-303. Raven Press, New York. G. Nappi (Ed.).
46. Krieg S.M., Slawik H., Meyer B., Wiegand M., Stoffel M. Sleep disturbance after pinealectomy in patients with pineocytoma WHOI. Acta Neurochir 2012, 154:1399-1405.
47. Yoneyama S., Hashimoto S., Honma K. Seasonal changes of human circadian rhythms in Antarctica. Am J Physiol 1999, 277:1091-1097.
48. Kauppila A., Kivela A., Pakarinen A., Vakkuri O. Inverse seasonal relationship between melatonin and ovarian activity in humans in a region with a strong seasonal contrast in luminosity. J Clin Endocrinol Metab 1987, 65:823-828.
49. Wehr T.A. The durations of human melatonin secretion and sleep respond to changes in daylength (photoperiod). J Clin Endocrinol Metab 1991, 73:1276-1280.
50. Wehr T.A. Photoperiodism in humans and other primates: evidence and implications. J Biol Rhythms 2001, 16:348-364.
51. Wehr T.A., Giesen H.A., Moul D.E., Turner E.H., Schwartz P.J. Suppression of men's responses to seasonal changes in day length by modern artificial lighting. Am J Physiol 1995, 269:173-178.
52. Lewy A.J., Sack R.L., Miller L.S., Hoban T.M. Antidepressant and circadian phase shifting effects of light. Science 1987, 235:352-354.
53. Wehr T.A., Jacobsen F.M., Sack D.A., Turner E.H., Schwartz P.J. Phototherapy of seasonal affective disorder: time of day and suppression of melatonin are not critical for antidepressant effects. Arch Gen Psychiatry 1986, 43:870-875.
54. Wirz-Justice A., Graw P., Krauchi K., Gisin B., Jochum A., Arendt J., et al. Light therapy in seasonal affective disorder is independent of time of day or circadian phase. Arch Gen Psychiatry 1993, 50:929-937.
55. Claustrat B., Brun J., Geoffiau M., Chazot G. Melatonin: from the hormone to the drug?. Restor Neurol Neurosci 1998, 12:151-157.
56. Armstrong S.M. Melaton: the internal zeitgeber of mammals?. Pineal Res Rev 1989, 7:157-202.
57. Strassmann R.J., Qualls C.R., Lisansky E.J., Peake G.T. Elevated rectal temperature produced by all-night bright light is reversed by melatonin infusion in men. J Appl Physiol 1991, 71:2178-2182.
58. Van der Helm-van Mil A.H., van Someren E.J., van den Boom R., van Buchem M.A., de Craen A.J., Blauw G.J. No influence of melatonin on cerebral blood flow in humans. J Clin Endocrinol Metab 2003, 4:5989-5994.
59. Torres-Farfan C., Richter H.G., Rojas-Garcia P., Vergara M., Forcelledo M.L., Valladares L.E., et al. mt1 Melatonin receptor in the primate adrenal gland: inhibition of adrenocorticotropin-stimulated cortisol production by Melatonin. J Clin Endocrinol Metab 2003, 88:450-458.
60. Akerstedt T., Froberg J.E., Friberg Y., Wetterberg L. Melatonin excretion, body temperature and subjective arousal during 64hours of sleep deprivation. Psychoneuroendocrinology 1979, 4:219-225.
61. Cajochen C., Zeitzer J.M., Czeisler C.A., Dijk D.J. Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness. Behav Brain Res 2000, 115:75-83.
62. Aeschbach D., Sher L., Postolache T.T., Matthews J.R., Jackson M.A., Wehr T.A. A longer biological night in long sleepers than in short sleepers. J Clin Endocrinol Metab 2003, 88:26-30.
63. Lavie P. Melaton: role in gating nocturnal rise in sleep propensity. J Biol Rhythms 1997, 12:657-665. [Review].
64. Wade A.G., Ford I., Crawford G., McMahon A.D., Nir T., Laudon M., et al. Efficacy of prolonged release melatonin in insomnia patients aged 55-80years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin 2007, 23:2597-2605.
65. Rivkees S.A. Developing circadian rhythmicity in infants. Pediatrics 2003, 112:373-381.
66. Lewy A.J., Ahmed S., Jackson J.M., Sack R.L. Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol Int 1992, 9:380-392.
67. Zaïdan R., Geoffriau M., Brun J., Taillard J., Bureau C., Chazot G., et al. Melatonin in able to influence its secretion in humans: description of a phase-response curve. Neuroendocrinology 1994, 60:105-112.
68. Guerrero J.M., Reiter R.J. Melatonin-immune system relationships. Curr Top Med Chem 2002, 2:167-179.
69. Withyachumnarnkul B., Nonaka K.O., Santana C., Attia A.M., Reiter R.J. Interferon-gamma modulates melatonin production in rat pineal glands in organ culture. J Interferon Res 1990, 10:403-411.
70. Sutherland E.R., Martin R.J., Ellison M.C., Kraft M. Immunomodulatory effects of melatonin in asthma. Am J Respir Crit Care Med 2002, 166:1055-1061.
71. Sulli A., Maestroni G.J.M., Villaggio B., Hertens E., Craviotto C., Pizzorni C., et al. Melatonin serum levels in rheumatoid arthritis. Ann N Y Acad Sci 2002, 966:276-283.
72. Bartsch H., Bartsch C. Effect of melatonin on experimental tumors under different photoperiods and times of administration. J Neural Transm 1981, 52:269-279.
73. Lissoni P., Chilelli M., Villa S., Cerizza L., Tancini G. Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial. J Pineal Res 2003, 35:12-15.
74. Ekmekcioglu C. Melatonin receptors in humans: biological role and clinical relevance. Biomed Pharmacother 2006, 60:97-108. [Review].
75. Cardinali D.P., Golombek D.A., Rosenstein R.E., Cutrera R.A., Esquifino A.I. Melatonin site and mechanism of action: single or multiple?. J Pineal Res 1997, 23:32-39.
76. Dubocovich M.L., Delagrange P., Krause D.N., Sugden D., Cardinali D.P., Olcese J. International union of basic and clinical pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Pharmacol Rev 2010, 62:343-380.
77. Ebisawa T., Uchiyama M., Kajimura N., Kamei Y., Shibui K., Kim K., et al. Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls. Neurosci Lett 2000, 280:29-32.
78. Carrillo A., Garcia-Perganeda A., Naji L., Calvo J.R., Romero M.P., Guerrero J.M. Expression of membrane and nuclear melatonin receptor mRNA and protein in the mouse immune system. Cell Mol Life Sci 2003, 60:2272-2278.
79. Poeggeler B., Saarela S., Reiter R.J., Tan D.X., Chen L.D., Manchester L.C., et al. Melatonin: a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro. Ann N Y Acad Sci 1994, 17:419-420.
80. Manev H., Uz T., Kharlamov A., Cagnoli C.M., Franceschini D., Giusti P. In vivo protection against kainate-induced apoptosis by the pineal hormone melatonin: effect of exogenous melatonin and circadian rhythm. Restor Neurol Neurosci 1996, 9:251-256.
81. Gitto E., Karbownik M., Reiter R.J., et al. Effects of melatonin treatment in septic newborns. Pediatr Res 2001, 50:756-760.