Berberine exhibits antitumor effects in human ovarian cancer cells

Anti-Cancer Agents in Medicinal Chemistry

Volumn 15, Issue 4, 2015, Pages 511-516

  Jin, Ping ^a   Zhang, Chunjie ^b   Li, Na ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b LANZHOU UNIVERSITY   (China)

Author keywords

Berberine; Methylation; Mismatch repair genes; Ovarian cancer; SKOV3 cells

Indexed keywords

BERBERINE; CISPLATIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MLH1; SURVIVIN; ANTINEOPLASTIC AGENT; BIRC5 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DEMETHYLATION; DOWN REGULATION; DRUG MECHANISM; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MTT ASSAY; OVARY CANCER; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; CPG ISLAND; DRUG EFFECTS; DRUG POTENTIATION; FEMALE; GENETICS; METABOLISM; METHYLATION; OVARY TUMOR; PATHOLOGY; PROMOTER REGION; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTINEOPLASTIC AGENTS; APOPTOSIS; BERBERINE; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; CPG ISLANDS; DRUG SYNERGISM; FEMALE; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; METHYLATION; NUCLEAR PROTEINS; OVARIAN NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84929674628     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520614666141226124110     Document Type: Article

References (27)

1. Ween, M.P.; Oehler, M.K.; Ricciardelli, C. Role of versican, hyaluronan and CD44 in ovarian cancer metastasis. Int. J. Mol. Sci., 2011, 12(2), 1009-1029.
2. Chen, H.; Hardy, T.M.; Tollefsbol, T.O. Epigenomics of ovarian cancer and its chemoprevention. Front. Genet., 2011, 2, 67.
3. Li, N.; Zhang, H.; Zhao, Q.Inhibition the Proliferation of the Human Ovarian Cancer Cell SKOV3/CDDP in vitro by Dihydroartemisinin. J. Pract. Obstet. Gynaecol., 2010, 26, 348-351.
4. Chen, S.; Cooper, M.; Jones, M.; Madhuri, T.K.; Wade, J.; Bachelor, A.; Butler-Manuel, S. Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. Cell Biol.Toxicol., 2011, 27(2), 133-147.
5. Jiao, J.W.; Wen, F. Tanshinone IIA acts via p38 MAPK to induce apoptosis and the down-regulation of ERCC1 and lung-resistance protein in cisplatin-resistant ovarian cancer cells. Oncol. Rep., 2011, 25(3), 781-788.
6. Ma, L.; Li, L.; Jiang, Y.; Shi, L.Y.; Feng, B.M.; Wang, Y.Q.; Tang, L. Youchasaponin induces apoptosis of human leukemia Jurkat cells in vitro and its possible mechanism. Tumor, 2011, 31, 1072-1076.
7. Li, N.; Fan, L.L.; Sun, G. P.; Wan, X.A.; Wang, Z.G.; Wu, Q.; Wang, H. Paeonol inhibits tumor growth in gastric cancer in vitro and in vivo. World J. Gastroenterol., 2010, 16(35), 4483-4490.
8. Yan, K.; Zhang, C.; Feng, J.; Hou, L.; Yan, L.; Zhou, Z.; Liu, Z.; Liu, C.; Fan, Y.; Zheng, B.; Xu, Z. Induction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells. Eur. J. Pharmacol., 2011, 661(1-3), 1-7.
9. Hu, S.L.; Huang, D.B.; Sun, Y.B.; Wu, L.; Xu, W.P.; Yin, S.; Chen, J.; Jiang, X.D.; Shen, G. Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer. Med. Oncol., 2011, 28(2), 447-454.
10. Wang, F.; Xie, X.J.; Piao, Y.S.; Liu, B.; Wang, L.D. Methylation of p16 and hMLH1 genes in esophageal squamous cell carcinoma and reflux esophagitis. Zhonghua Bing Li Xue Za Zhi, 2011, 40(8), 537-541.
11. Hayashi, M.; Nomoto, S.; Kanda, M.; Okamura, Y.; Nishikawa, Y.; Yamada, S.; Fujii, T.; Sugimoto, H.; Takeda, S.; Kodera, Y. Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma. J. Surg. Oncol., 2012, 105(4), 381-386.
12. Bondurant, A.E.; Huang, Z.; Whitaker, R.S.; Simel, L.R.; Berchuck, A.; Murphy, S.K. Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer. Gynecol. Oncol., 2011, 123(3), 581-587.
13. Yang, D.; Khan, S.; Sun, Y.; Hess, K.; Shmulevich, I.; Sood, A.K.; Zhang, W. Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer. JAMA, 2011, 306(14), 1557-1565.
14. Cul'Bova, M.; Lasabova, Z.; Stanclova, A.; Tilandyova, P.; Zubor, P.; Fiolka, R.; Danko, J.; Visnovsky, J. Methylation of selected tumor-supressor genes in benign and malignant ovarian tumors. Ceska. Gynekol., 2011, 76(4), 274-279.
15. Qiu, H.; Zhu, J.; Yu, J.; Pu, H.; Dong, R. SLIT2 is epigenetically silenced in ovarian cancers and suppresses growth when activated. Asi. Pac. J. Cancer Prev., 2011, 12(3), 791-795.
16. Chai, X. J.; Luan, J.; Yang, W. L.; Zhang, Y. C.; Ge, Y. J.; Qin, Y. Traditional medicine CDP and promoter demethylation in breast cancer cell lines. Sichuan Da Xue Xue Bao Yi Xue Ban, 2009, 40(5), 798-802.
17. Mahata, S.; Bharti, A.C.; Shukla, S.; Tyagi, A.; Husain, S. A.; Das, B. C. Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Mol. Cancer, 2011, 10, 39.
18. Zhang, H.; Zhang, S.; Cui, J.; Zhang, A.; Shen, L.; Yu, H. Expression and promoter methylation status of mismatch repair gene hMLH1 and hMSH2 in epithelial ovarian cancer. Aust. N. Z. J. Obstet. Gynaecol., 2008, 48(5), 505-509.
19. Ahamed, M.; Akhtar, M.J.; Siddiqui, M.A.; Ahmad, J.; Musarrat, J.; Al-Khedhairy, A.A.; AlSalhi, M.S.; Alrokayan, S.A. Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells. Toxicology, 2011, 283(2-3), 101-108.
20. Wu, F.; Hu, C.H. Reversal effect of 5-Aza-dc on cisplatinresistance in human NSCLC cells in vitro. Zhonghua Zhong Liu Za Zhi, 2011, 33(5), 349-353.
21. Azad, N.; Iyer, A.; Vallyathan, V.; Wang, L.; Castranova, V.; Stehlik, C.; Rojanasakul, Y. Role of oxidative/nitrosative stressmediated Bcl-2 regulation in apoptosis and malignant transformation. Ann. N. Y. Acad. Sci., 2010, 1203, 1-6.
22. Kanwar, R.K.; Cheung, C.H.; Chang, J.Y.; Kanwar, J.R. Recent advances in anti-survivin treatments for cancer. Curr. Med. Chem., 2010, 17(15), 1509-1515.
23. Meng, C. F.; Dai, D. Q.; Guo, K. J. Effects of 5-Aza-2'-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH1 in ovarian cancer cell line COC1/DDP. Ai Zheng, 2008, 27(12), 1251-1255.
24. Stasikowska-Kanicka, O.; Stawerski, P.; Wagrowska-Danilewicz, M.; Danilewicz, M. Immunohistochemical analysis of hMLH1 and hMSH2 proteins in serous ovarian tumours. Pol. J. Pathol., 2009, 60(4), 174-178.
25. Park, K.S.; Kim, J.B.; Lee, S.J.; Bae, J. Berberine-induced growth inhibition of epithelial ovarian carcinoma cell lines. J. Obstet. Gynaecol. Res., 2012, 38(3), 535-540.
26. Liu, S.; Fang, Y.; Shen, H.; Xu, W.; Li, H. Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis. Acta Biochim. Biophys. Sin., 2013, 45(9), 756-762.
27. Daigle, S.R.; Olhava, E.J.; Therkelsen, C.A.; Basavapathruni, A.; Jin, L.; Boriack-Sjodin, P.A.; Allain, C.J.; Klaus, C.R.; Raimondi, A.; Scott, M.P.; Waters, N. J.; Chesworth, R.; Moyer, M. P.; Copeland, R.A.; Richon, V.M.; Pollock, R.M. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood, 2013, 122(6), 1017-1025.