Sensitivity of neoplastic cells to senescence unveiled under standard cell culture conditions

Anticancer Research

Volumn 35, Issue 5, 2015, Pages 2759-2768

  Zieba, Jolanta ^a   Ksiazkiewcz, Magdalena ^a   Janik, Karolina ^a   Banaszczyk, Mateusz ^a   Peciak, Joanna ^a   Piaskowski, Sylwester ^a   Lipinski, Marek ^b   Olczak, Michal ^b   Stoczynska Fidelus, Ewelina ^a   Rieske, Piotr ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b Celther Polska Ltd   (Poland)

Author keywords

Cancer cell line; Oncogene induced senescence; Primary cell culture; Senescence; Senescence associated heterochromatin foci; Senescence associated galactosidase

Indexed keywords

BETA GALACTOSIDASE; MAMMAGLOBIN A; MUCIN 1; PROTEIN P53; MUC1 PROTEIN, HUMAN; SCGB2A2 PROTEIN, HUMAN;

ARTICLE; BREAST CANCER; CANCER CELL LINE; CELL CULTURE; CELL POPULATION; COLORECTAL CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MALE; MCF 7 CELL LINE; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; ONCOGENE INDUCED SENESCENCE; PRIMARY TUMOR; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE; BIOSYNTHESIS; BREAST NEOPLASMS; CELL AGING; COLONIC NEOPLASMS; DRUG EFFECTS; FEMALE; GENETICS; PATHOLOGY; PROSTATIC NEOPLASMS;

BREAST NEOPLASMS; CELL AGING; COLONIC NEOPLASMS; FEMALE; HUMANS; MALE; MAMMAGLOBIN A; MCF-7 CELLS; MUCIN-1; PROSTATIC NEOPLASMS;

EID: 84929662346     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Blagosklonny MV: Cell-cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging (Albany NY) 4(3): 159-165, 2012.
2. Demidenko ZN and Blagosklonny MV: Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 7: 3355-3361, 2008.
3. Serrano M, Lim AW, McCurrach ME, Beach D and Lowe SW: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK1A. Cell 88: 593-602, 1997.
4. Lee YH, Kang BS and Bae YS: Premature senescence in human breast cancer and colon cancer cells by tamoxifen-mediated reactive oxygen species generation. Life Sci 97(2): 116-22, 2014.
5. Villalonga-Planells R, Coll-Mulet L, Martínez-Soler F, Castaño E, Acebes JJ, Giménez-Bonafé P, Gil J and Tortosa A: Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme. PLoS One 6(4): e18588, 2011.
6. Stoczynska-Fidelus E, Piaskowski S, Bienkowski M, Banaszczyk M, Hulas-Bigoszewska K, Winiecka-Klimek M, Radomiak-Zaluska A, Och W, Borowiec M, Zieba J, Treda C and Rieske P: The failure in the stabilization of glioblastoma-derived cell lines: spontaneous in vitro senescence as the main culprit. PLoS One 9(1): e87136, 2014.
7. Stoczynska-Fidelus E, Och W, Rieske P, Bienkowski M, Banaszczyk M, Winiecka-Klimek M, Zieba J, Janik K, Rosiak K, Treda C, Stawski R, Radomiak-Zaluska A and Piaskowski S: Spontaneous in vitro senescence of glioma cells confirmed by an antibody against IDH1R132H. Anticancer Res 34(6): 2859-67, 2014.
8. Stoczynska-Fidelus E, Bienkowski M, Pacholczyk M, Winiecka-Klimek M, Banaszczyk M, Zieba J, Bieniek G, Piaskowski S and Rieske P: Different mutational characteristics of TSG in cell lines and surgical specimens. Tumour Biol 35(11): 11311-11318, 2014.
9. Park JG, Ku JL, Park SY: Isolation and Culture of Colon Cancer Cell Lines. Methods in Molecular Medicine, vol. 88: Cancer Cell Culture: Methods and Protocols. Edited by S. P. Langdon, Humana Press Inc., Totowa, NJ 79-92, 2003.
10. Pfaffl MW, Horgan GW and Dempfle L: Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36, 2002.
11. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O et al: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92(20): 9363-9367, 1995.
12. Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K et al: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483(7391): 603-607, 2012.
13. Forbes SA, Beare D, Gunasekaran P, Leung K, Bindal N, Boutselakis H, Ding M, Bamford S, Cole C, Ward S, Kok CY, Jia M, De T, Teague JW, Stratton MR, McDermott U and Campbell PJ: COSMIC: exploring the world's knowledge of somatic mutations in human cancer. Nucl Acids Res 43(D1): D805-D811, 2015.
14. Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguría A, Zaballos A, Flores JM, Barbacid M, Beach D and Serrano M: Tumour biology: senescence in premalignant tumours. Nature 436(7051): 642, 2005.
15. te Poele RH, Okorokov AL, Jardine L, Cummings J and Joel SP: DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 62(6): 1876-1883, 2002.
16. Ansieau S, Bastid J, Doreau A, Morel AP, Bouchet BP, Thomas C, Fauvet F, Puisieux I, Doglioni C, Piccinin S, Maestro R, Voeltzel T, Selmi A, Valsesia-Wittmann S, Caron de Fromentel C and Puisieux A: Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 14(1): 79-89, 2008.
17. Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ and Lowe SW: Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol 22(10): 3497-508, 2002.
18. Courtois-Cox L, Genther-Williams SM, Reczek EE et al: A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 10: 459-472, 2006.
19. Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ and Peeper DS: BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436: 720-724, 2005.
20. Kosar M1, Bartkova J, Hubackova S, Hodny Z, Lukas J and Bartek J: Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle 10(3): 457-468, 2011.