Precursors of hexoneogenesis within the human mammary gland

American Journal of Physiology - Endocrinology and Metabolism

Volumn 308, Issue 8, 2015, Pages E680-E687

  Mohammad, Mahmoud A ^a   Maningat, Patricia ^a   Sunehag, Agneta L ^a   Haymond, Morey W ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Galactose; Gluconeogenesis; Lactose synthesis; Pentose phosphate pathway; Stable isotopes GC MS

Indexed keywords

ACETIC ACID; GALACTOSE; GLUCOSE; GLUTAMINE; GLYCEROL; LACTIC ACID; CARBON; GLUCOSE BLOOD LEVEL; LACTOSE;

ARTICLE; BREAST MILK; CARBON SOURCE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCEROL BLOOD LEVEL; HUMAN; LIPID DIET; MACRONUTRIENT; MAMMARY GLAND; MILK PRODUCTION; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; SYNTHESIS; ADULT; ANALYSIS; BIOSYNTHESIS; BLOOD; BREAST FEEDING; CHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; LACTATION; METABOLISM; UNITED STATES;

ADULT; BLOOD GLUCOSE; BREAST FEEDING; CARBON ISOTOPES; FEMALE; GALACTOSE; GLUCONEOGENESIS; GLUCOSE; GLUTAMINE; GLYCEROL; HUMANS; INFUSIONS, INTRAVENOUS; LACTATION; LACTIC ACID; LACTOSE; MAMMARY GLANDS, HUMAN; MILK, HUMAN; PENTOSE PHOSPHATE PATHWAY; SODIUM ACETATE; TEXAS;

EID: 84929617167     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00356.2014     Document Type: Article

References (35)

1. Baba H, Zhang XJ, Wolfe RR. Glycerol gluconeogenesis in fasting humans. Nutrition 11: 149–153, 1995.
2. Beylot M, Previs SF, David F, Brunengraber H. Determination of the 13C-labeling pattern of glucose by gas chromatography-mass spectrometry. Anal Biochem 212: 526–531, 1993.
3. Consoli A, Nurjhan N, Reilly JJ Jr, Bier DM, Gerich JE. Contribution of liver and skeletal muscle to alanine and lactate metabolism in humans. Am J Physiol Endocrinol Metab 259: E677–E684, 1990.
4. Cowie AT, Duncombe WG, Folley SJ, French TH, Glascock RF, Massart L, Peeters GJ, Popjak G. Synthesis of milk fat from acetic acid (CH3 14COOH) by the perfused isolated bovine udder. Biochem J 49: 610–615, 1951.
5. Davis TA, Nguyen HV, Garcia-Bravo R, Fiorotto ML, Jackson EM, Lewis DS, Lee DR, Reeds PJ. Amino acid composition of human milk is not unique. J Nutr 124: 1126–1132, 1994.
6. Gerich JE. Control of glycaemia. Baillieres Clin Endocrinol Metab 7: 551–586, 1993.
7. Hankard RG, Haymond MW, Darmaun D. Role of glutamine as a glucose precursor in fasting humans. Diabetes 46: 1535–1541, 1997.
8. Hansen RG, Wood HG, Peeters GJ, Jacobson B, Wilken J. Lactose synthesis VI. Labeling of lactose precursors by glycerol-1,3-C-14 and glucose-2-C-14. J Biol Chem 237: 1034–1039, 1962.
9. Haymond MW, Sunehag AL. The reciprocal pool model for the measurement of gluconeogenesis by use of [U-13C]glucose. Am J Physiol Endocrinol Metab 278: E140–E145, 2000.
10. Jensen DR, Bessesen DH, Etienne J, Eckel RH, Neville MC. Distribution and source of lipoprotein lipase in mouse mammary gland. J Lipid Res 32: 733–742, 1991.
11. Jensen DR, Gavigan S, Sawicki V, Witsell DL, Eckel RH, Neville MC. Regulation of lipoprotein lipase activity and mRNA in the mammary gland of the lactating mouse. Biochem J 298: 321–327, 1994.
12. Jenssen T, Nurjhan N, Consoli A, Gerich JE. Dose-response effects of lactate infusions on gluconeogenesis from lactate in normal man. Eur J Clin Invest 23: 448–454, 1993.
13. Kaplan W, Sunehag AL, Dao H, Haymond MW. Short-term effects of recombinant human growth hormone and feeding on gluconeogenesis in humans. Metab Clin Exper 57: 725–732, 2008.
14. McBride OW, Korn ED. The uptake of doubly labeled chylomicrons by guinea pig mammary gland and liver. J Lipid Res 5: 459–467, 1964.
15. Mendelson CR, Scow RO. Uptake of chylomicron-triglyceride by perfused mammary tissue of lactating rats. Am J Physiol 223: 1418–1423, 1972.
16. Meyer C, Stumvoll M, Dostou J, Welle S, Haymond M, Gerich J. Renal substrate exchange and gluconeogenesis in normal postabsorptive humans. Am J Physiol Endocrinol Metab 282: E428–E434, 2002.
17. Mohammad MA, Haymond MW. Regulation of lipid synthesis genes and milk fat production in human mammary epithelial cell during secretory activation. Am J Physiol Endocrinol Metab 305: E700–E716, 2013.
18. Mohammad MA, Sunehag AL, Chacko SK, Pontius AS, Maningat PD, Haymond MW. Mechanisms to conserve glucose in lactating women during a 42-h fast. Am J Physiol Endocrinol Metab 297: E879–E888, 2009.
19. Mohammad MA, Sunehag AL, Haymond MW. De novo synthesis of milk triglycerides in humans. Am J Physiol Endocrinol Metab 306: E60–E71, 2014.
20. Mohammad MA, Sunehag AL, Haymond MW. Effect of dietary macronutrient composition under moderate hypocaloric intake on maternal adaptation during lactation. Am J Clin Nutr 89: 1821–1827, 2009.
21. Mohammad MA, Sunehag AL, Rodriguez LA, Haymond MW. Galactose promotes fat mobilization in obese lactating and nonlactating women. Am J Clin Nutr 93: 374–381, 2010.
22. Neville MC, Keller R, Seacat J, Lutes V, Neifert M, Casey C, Allen J, Archer P. Studies in human lactation: milk volumes in lactating women during the onset of lactation and full lactation. Am J Clin Nutr 48: 1375–1386, 1988.
23. Neville MC, Waxman LJ, Jensen D, Eckel RH. Lipoprotein lipase in human milk: compartmentalization and effect of fasting, insulin, and glucose. J Lipid Res 32: 251–257, 1991.
24. Schambye P, Wood HG, Kleiber M. Lactose synthesis I. The distribution of C14 in lactose of milk after intravenous injection of C14 compounds. J Biol Chem 226: 1011–1021, 1957.
25. Scott RA, Beuman DE, Clark JH. Cellular gluconeogenesis by lactating bovine mammary tissue. J Dairy Sci 59: 50–56, 1976.
26. Sunehag AL, Louie K, Bier JL, Tigas S, Haymond MW. Hexoneogenesis in the human breast during lactation. J Clin Endocrinol Metab 87: 297–301, 2002.
27. Tigas S, Sunehag A, Haymond MW. Metabolic adaptation to feeding and fasting during lactation in humans. J Clin Endocrinol Metab 87: 302–307, 2002.
28. van Hall G, Sacchetti M, Radegran G. Whole body and leg acetate kinetics at rest, during exercise and recovery in humans. J Physiol 542: 263–272, 2002.
29. Weinman EO, Strisower EH, Chaikoff IL. Conversion of fatty acids to carbohydrate: application of isotopes to this problem and role of the Krebs cycle as a synthetic pathway. Physiol Rev 37: 252–272, 1957.
30. West CE, Bickerstafee R, Annison EF, Linzell JL. Studies on the mode of uptake of blood triglycerides by the mammary gland of the lactating goat. The uptake and incorporation into milk fat and mammary lymph of labelled glycerol, fatty acids and triglycerides. Biochem J 126: 477–490, 1972.
31. Wood HG, Gillespie R, Joffe S, Hansen RG, Hardenbrook H. Lactose synthesis V. C14 in lactose, glycerol, and serine as indicators of the triose phosphate isomerase reaction and pentose cycle. J Biol Chem 233: 1271–1278, 1958.
32. Wood HG, Joffe S, Gillespie R, Hansen RG, Hardenbrook H. Lactose synthesis. IV. The synthesis of milk constituents after unilateral injection of glycerol-1,3-C14 into the pudic artery. J Biol Chem 233: 1264–1270, 1958.
33. Wood HG, Peeters GJ, Verbeke R, Lauryssens M, Jacobson B. Estimation of the pentose cycle in the perfused cow’s udder. Biochem J 96: 607–615, 1965.
34. Wood HG, Schambye P, Peeters GJ. Lactose synthesis II. The distribution of C14 in lactose of milk from the perfused isolated cow udder. J Biol Chem 226: 1023–1034, 1957.
35. Wood HG, Siu P, Schambye P. Lactose synthesis III. The distribution of C14 in lactose of milk after intra-arterial injection of acetate-1-C 14. Arch Biochem Biophys 69: 390–404, 1957.