Role of glutamine as a glucose precursor in fasting humans

Diabetes

Volumn 46, Issue 10, 1997, Pages 1535-1541

  Hankard, Régis G ^a   Haymond, Morey W ^a   Darmaun, Dominique ^b,c  

^a NEMOURS CHILDREN S CLINIC   (United States)

^b CHU de Nantes   (France)

^c HÔTEL DIEU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; GLUCOSE; GLUTAMINE;

AMINO ACID ANALYSIS; ARTICLE; CITRIC ACID CYCLE; DIET RESTRICTION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 0030802677     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.46.10.1535     Document Type: Article

References (29)

1. Bergström J, Fürst P, Norée L, Vinnars E: Intracellular free amino acid concentration in human muscle tissue. J Appl Physiol 36:693-697, 1974
2. Felig P: Amino acid metabolism in man. Annu Rev Biochem 44:933-955, 1975
3. Matthews DE, Marano MA, Campbell RG: Splanchnic bed utilization of glutamine and glutamic acid in humans. Am J Physiol 264:E848-E854, 1993
4. Hankard R, Darmaun D, Sager BK, D'Amore D, Parsons WR, Haymond MW: Response of glutamine metabolism to exogenous glutamine in humans. Am J Physiol 269:E663-E670, 1995
5. Souba WW: Glutamine: a key substrate for the splanchnic bed. Annu Rev Nutr 11:285-308, 1991
6. Nurjhan N, Bucci A, Perriello G, Stumvoll M, Dailey G, Bier D, Toft I, Jenssen T, Gerich J: Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J Clin Invest 95:272-277, 1995
7. 2 in estimating rates of hepatic gluconeogenesis. Am J Physiol 263:E36-E41, 1992
8. Durnin JVGA, Womersley J: Body fat assessed from total body density and its estimation from skinfold thickness measurement on 481 men and women aged 16 to 72 years. Br J Nutr 32:77-97, 1974
9. Abumrad NN, Rabin D, Diamond MP, Lacy WW: Use of a heated hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism 30:936-940, 1981
10. deWeir JB: New methods for calculating metabolic rate with reference to protein metabolism. J Appl Physiol 109:1-9, 1949
11. Nissen S, Haymond MW: Changes in leucine kinetics during meal absorption: effects of dietary availability. Am J Physiol 250:E695-E701, 1986
12. Darmaun D, Manary M, Matthews D: A method for measuring both glutamine and glutamate levels and stable isotope enrichments. Anal Biochem 147:97-102, 1985
13. Wolfe RR: Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York, Wiley-Liss, 1992
14. 13C-labelled glucose at a very low level of enrichment in man. Diabetologia 33:449-456, 1990
15. Guilluy R, Billion-Rey F, Pachiaudi C, Normand S, Riou JP, Jumeau EJ, Brazier JL: On-line purification and carbon-13 isotopic analysis of carbon dioxide in breath: evaluation of on-line gas chromatography-isotope ratio mass spectrometry. Anal Chim Acta 259:193-202, 1992
16. Horber FF, Kahl J, Lecavalier L, Krom B, Haymond MW: Determination of leucine and α-ketoisocaproic acid concentrations and specific activity in plasma and leucine specific activities in proteins using high performance liquid chromatography. J Chromatogr 495:81-84, 1989
17. 3 infused by gut and vein: effect of feeding. Am J Physiol 257:E426-E438, 1989
18. Consoli A, Kennedy F, Miles J, Gerich J: Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man. J Clin Invest 80:1303-1310, 1987
19. 2O for estimating rates of gluconeogenesis. J Clin Invest 95:172-178, 1995
20. Gan-Gaisano MC, Horber FF, Haymond MW: In vivo estimates of gluconeogenesis using labeled bicarbonate, leucine or KIC (Abstract). Diabetes 39 (Suppl. 1):25A, 1990
21. Matthews DE, Bier DM, Rennie MJ, Edwards RHT, Halliday D, Millward DJ, Clugston GA: Regulation of leucine metabolism in man: a stable isotope study. Science 213:1129-1131, 1981
22. Harper AE, Miller RH, Block KP: Branched chain amino acid metabolism. Annu Rev Nutr 4:409-430, 1984
23. Sidossis LS, Coggan AR, Gastaldelli A, Wolfe RR: Pathway of free fatty acid oxidation in human subjects: implications for tracer studies. J Clin Invest 95:278-284, 1995
24. Darmaun D, Matthews DE, Bier DM: Glutamine and glutamate kinetics in humans. Am J Physiol 251:E117-E126, 1986
25. Darmaun D, Matthews DE, Desjeux JF, Bier DM: Glutamine and glutamate nitrogen exchangeable pools in cultured fibroblasts: a stable isotope study. J Cell Physiol 134:143-148, 1988
26. Lacey JM, Wilmore DW: Is glutamine a conditionally essential amino acid? Nutr Rev 48:297-309, 1990
27. Hankard RG, Haymond MW, Darmaun D: Effect of glutamine on leucine metabolism in humans. Am J Physiol 271:E748-E754, 1996
28. Darmaun D, Déchelotte P: Role of leucine as a precursor of glutamine α-amino nitrogen in vivo in humans. Am J Physiol 260:E326-E329, 1991
29. Bier DM: Intrinsically difficult problems: the kinetics of body proteins and amino acids in man. Diabetes Metab Rev 5:111-132, 1989