Increasing the density of nanomedicines improves their ultrasound-mediated delivery to tumours

Journal of Controlled Release

Volumn 210, Issue , 2015, Pages 10-18

  Mo, Steven ^a   Carlisle, Robert ^a   Laga, Richard ^a,b   Myers, Rachel ^a   Graham, Susan ^a   Cawood, Ryan ^a   Ulbrich, Karel ^b   Seymour, Leonard ^a   Coussios, Constantin C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

Author keywords

Delivery; Density; Pharmacokinetics; Stealthing; Tumour; Ultrasound; Virotherapy

Indexed keywords

DENSITY (SPECIFIC GRAVITY); FIBER OPTIC SENSORS; GOLD; LIPOSOMES; MEDICAL NANOTECHNOLOGY; METAL NANOPARTICLES; NANOPARTICLES; PHARMACOKINETICS; ULTRASONICS; VIRUSES;

CLINICAL UTILITY; DELIVERY; GOLD NANOPARTICLES; METHACRYLAMIDES; NANO SCALE; NANOMEDICINES; STEALTHING; VIROTHERAPY;

TUMORS;

CAPSID PROTEIN; GOLD NANOPARTICLE; MACROGOL; NANOCOATING; ONCOLYTIC ADENOVIRUS; POLY[N (2 HYDROXYPROPYL)METHACRYLAMIDE]; THIOL DERIVATIVE; GOLD; GREEN FLUORESCENT PROTEIN; MACROGOL DERIVATIVE; METAL NANOPARTICLE; POLYMETHACRYLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER CELL LINE; CANCER GROWTH; CANCER INHIBITION; CANCER SURVIVAL; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISULFIDE BOND; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; ENTEROVIRUS; EXTRAVASATION; FEMALE; GENE EXPRESSION; HIGH INTENSITY FOCUSED ULTRASOUND; HUMAN; HUMAN ADENOVIRUS 5; HUMAN CELL; HYDRODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; MOUSE; NANOANALYSIS; NANOFILTRATION; NANOMEDICINE; NONHUMAN; ONCOLYTIC VIROTHERAPY; OVARIAN CANCER CELL LINE; PARTICLE SIZE; PHARMACOLOGICAL PARAMETERS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STEALTHING; SURFACE CHARGE; SURFACE PROPERTY; SYSTEMATIC REVIEW; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR MICROENVIRONMENT; TUMOR VOLUME; ZETA POTENTIAL; ADENOVIRIDAE; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; GENETICS; LIVER; METABOLISM; NEOPLASMS; NUDE MOUSE; TUMOR CELL LINE; ULTRASOUND;

ADENOVIRIDAE; ANIMALS; CELL LINE, TUMOR; FEMALE; GOLD; GREEN FLUORESCENT PROTEINS; HUMANS; LIVER; METAL NANOPARTICLES; MICE, INBRED BALB C; MICE, NUDE; NANOMEDICINE; NEOPLASMS; ONCOLYTIC VIROTHERAPY; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; ULTRASONICS;

EID: 84929611293     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.05.265     Document Type: Article

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