Ambient mass spectrometry imaging metabolomics method provides novel insights into the action mechanism of drug candidates

Analytical Chemistry

Volumn 87, Issue 10, 2015, Pages 5372-5379

  He, Jingjing ^a   Luo, Zhigang ^a   Huang, Lan ^c   He, Jiuming ^a   Chen, Yi ^b   Rong, Xianfang ^a   Jia, Shaobo ^a   Tang, Fei ^b   Wang, Xiaohao ^b   Zhang, Ruiping ^a   Zhang, Jianjun ^a   Shi, Jiangong ^a   Abliz, Zeper ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b TSINGHUA UNIVERSITY   (China)

^c INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; MASS SPECTROMETRY; METABOLISM; METABOLITES; MOLECULAR IMAGING; MOLECULES; NEUROPHYSIOLOGY; SPECTROMETRY; SPECTROSCOPY;

AMBIENT MASS SPECTROMETRIES; DESORPTION ELECTROSPRAY IONIZATION MASS SPECTROMETRIES; ENDOGENOUS METABOLITES; GAMMA-AMINOBUTYRIC ACIDS; GLYCEROPHOSPHOCHOLINE; HYPERSPECTRAL IMAGING; NEUROLOGICAL DISORDERS; SPATIOTEMPORAL DISTRIBUTIONS;

PRINCIPAL COMPONENT ANALYSIS;

ADENOSINE;

ANIMAL; CHEMISTRY; DATA MINING; DRUG SCREENING; MALE; MASS SPECTROMETRY; METABOLOMICS; MOLECULAR IMAGING; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES; RAT; SLEEP INITIATION AND MAINTENANCE DISORDERS; WISTAR RAT;

ADENOSINE; ANIMALS; DATA MINING; DRUG EVALUATION, PRECLINICAL; MALE; MASS SPECTROMETRY; METABOLOMICS; MOLECULAR IMAGING; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, WISTAR; SLEEP INITIATION AND MAINTENANCE DISORDERS;

EID: 84929593559     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/acs.analchem.5b00680     Document Type: Article

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