Global reported endophthalmitis risk following intravitreal injections of anti-VEGF: A literature review and analysis

Clinical Ophthalmology

Volumn 9, Issue , 2015, Pages 773-781

  Sigford, Douglas K ^a   Reddy, Shivani ^a   Mollineaux, Christine ^b   Schaal, Shlomit ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Endophthalmitis; Eye infections; Intravitreal injections; Panophthalmitis

Indexed keywords

ANTIBIOTIC AGENT; BEVACIZUMAB; POVIDONE IODINE; RANIBIZUMAB; VASCULOTROPIN INHIBITOR;

AGE RELATED MACULAR DEGENERATION; ANEURYSM; ARTICLE; BACTERIUM CULTURE; BRANCH RETINAL VEIN OCCLUSION; CENTRAL RETINA VEIN OCCLUSION; CENTRAL SEROUS RETINOPATHY; CHOROID DISEASE; CHOROID NEOVASCULAR MEMBRANE; CHOROIDAL NEOVASCULAR MEMBRANE; DIABETIC MACULAR EDEMA; ENDOPHTHALMITIS; HUMAN; IDIOPATHIC MACULAR TELANGIECTASIA; IRIS DISEASE; ISCHEMIC OPTIC NEUROPATHY; NEOVASCULAR GLAUCOMA; NEOVASCULARIZATION OF THE IRIS; NONARTERITIC ISCHEMIC OPTIC NEUROPATHY; OPERATING ROOM; OPHTHALMIC SPECULUM; POLYPOIDAL CHOROIDAL VASCULOPATHY; PROLIFERATIVE DIABETIC RETINOPATHY; RADIATION RETINOPATHY; RETINA DETACHMENT; RETINA DISEASE; RETINA MACULA CYSTOID EDEMA; RETINA VEIN OCCLUSION; RETINAL ANGIOMATOUS PROLIFERATION; RETINAL ARTERIAL MACROANEURYSM; RETINAL TELANGIECTASIA; RETINOPATHY; STREPTOCOCCUS; SURGICAL MASK;

EID: 84929578857     PISSN: 11775467     EISSN: 11775483     Source Type: Journal    
DOI: 10.2147/OPTH.S77067     Document Type: Article

References (29)

1. Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group, Martin DF, Maguire MG, et al. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology. 2012;119: 1388–1398.
2. Diabetic Retinopathy Clinical Research Network, Elman MJ, Qin H, et al. Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: three-year randomized trial results. Ophthalmology. 2012;119:2312–2318.
3. Heier JS, Campochiaro PA, Yau L, et al. Ranibizumab for macular edema due to retinal vein occlusions: long-term follow-up in the HORIZON trial. Ophthalmology. 2012;119:802–809.
4. Michels S, Rosenfeld PJ, Puliafito CA, Marcus EN, Venkatraman AS. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: twelve-week results of an uncontrolled open-label clinical study. Ophthalmology. 2005;112:1035–1047.
5. Rosenfeld PJ, Schwartz SD, Blumenkranz MS, et al. Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration. Ophthalmology. 2005;112:1048–1053.
6. Heier JS, Antoszyk AN, Pavan PR, et al. Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study. Ophthalmology. 2006;113:633.e1–e4.
7. CATT Research Group, Martin DF, Maguire MG, et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011;364:1897–1908.
8. Mason JO 3rd, White MF, Feist RM, et al. Incidence of acute onset endophthalmitis following intravitreal bevacizumab (Avastin) injection. Retina. 2008;28:564–567.
9. Fintak DR, Shah GK, Blinder KJ, et al. Incidence of endophthalmitis related to intravitreal injection of bevacizumab and ranibizumab. Retina. 2008;28:1395–1399.
10. Gonzalez S, Rosenfeld PJ, Stewart MW, Brown J, Murphy SP. Avastin doesn’t blind people, people blind people. Am J Ophthalmol. 2012; 153:196–203. e1.
11. Sheyman AT, Cohen BZ, Friedman AH, Ackert JM. An outbreak of fungal endophthalmitis after intravitreal injection of compounded combined bevacizumab and triamcinolone. JAMA Ophthalmol. 2013;131: 864–869.
12. Centers for Disease Control and Prevention. CDC responds to multistate outbreak of fungal meningitis and other infections. 2012. Available from: http://www.cdc.gov/HAI/outbreaks/currentsituation. Accessed July 30, 2013.
13. Alan R, Berger SS. Severe intraocular inflammation/endophthalmitis following off-label treatment with intravitreal bevacizumab. 2009. Available from: http://ophthalmologyrounds.ca/modules/contentManager/upload/document/alwaysOnLine/ScientificUpdate_en.pdf. Accessed January 8, 2015.
14. Yamashiro K, Tsujikawa A, Miyamoto K, et al. Sterile endophthalmitis after intravitreal injection of bevacizumab obtained from a single batch. Retina. 2010;30:485–490.
15. Wickremasinghe SS, Michalova K, Gilhotra J, et al. Acute intraocular inflammation after intravitreous injections of bevacizumab for treatment of neovascular age-related macular degeneration. Ophthalmology. 2008; 115:1911–1915.
16. Wang F, Yu S, Liu K, et al. Acute intraocular inflammation caused by endotoxin after intravitreal injection of counterfeit bevacizumab in Shanghai, China. Ophthalmology. 2013;120:355–361.
17. Goldberg RA, Flynn HW Jr, Isom RF, Miller D, Gonzalez S. An outbreak of Streptococcus endophthalmitis after intravitreal injection of bevacizumab. Am J Ophthalmol. 2012;153:204–208. e1.
18. Fielden M, Nelson B, Kherani A. Acute intraocular inflammation following intravitreal injection of bevacizumab–a large cluster of cases. Acta Ophthalmol. 2011;89:e664–e665.
19. McCannel CA. Meta-analysis of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents: causative organisms and possible prevention strategies. Retina. 2011;31:654–661.
20. Wen JC, McCannel CA, Mochon AB, Garner OB. Bacterial dispersal associated with speech in the setting of intravitreous injections. Arch Ophthalmol. 2011;129:1551–1554.
21. Simunovic MP, Rush RB, Hunyor AP, Chang AA. Endophthalmitis following intravitreal injection versus endophthalmitis following cataract surgery: clinical features, causative organisms and post-treatment outcomes. Br J Ophthalmol. 2012;96:862–866.
22. Chen E, Lin MY, Cox J, Brown DM. Endophthalmitis after intravitreal injection: the importance of viridans streptococci. Retina. 2011;31: 1525–1533.
23. Bhavsar AR, Stockdale CR, Ferris FL 3rd, Brucker AJ, Bressler NM, Glassman AR. Update on risk of endophthalmitis after intravitreal drug injections and potential impact of elimination of topical antibiotics. Arch Ophthalmol. 2012;130:809–810.
24. Cheung CS, Wong AW, Lui A, Kertes PJ, Devenyi RG, Lam WC. Incidence of endophthalmitis and use of antibiotic prophylaxis after intravitreal injections. Ophthalmology. 2012;119:1609–1614.
25. Bhatt SS, Stepien KE, Joshi K. Prophylactic antibiotic use after intravitreal injection: effect on endophthalmitis rate. Retina. 2011;31:2032–2036.
26. Kim SJ, Toma HS. Ophthalmic antibiotics and antimicrobial resistance: a randomized, controlled study of patients undergoing intravitreal injections. Ophthalmology. 2011;118:1358–1363.
27. Miño De Kaspar H, Hoepfner AS, Engelbert M, et al. Antibiotic resistance pattern and visual outcome in experimentally-induced Staphylococcus epidermidis endophthalmitis in a rabbit model. Ophthalmology. 2001;108:470–478.
28. Abell RG, Kerr NM, Allen P, Vote BJ. Intravitreal injections: is there benefit for a theatre setting? Br J Ophthalmol. 2012;96:1474–1478.
29. Li T, Dickersin K. Citation of previous meta-analyses on the same topic: a clue to perpetuation of incorrect methods? Ophthalmology. 2013;120: 1113–1119.