Psychological distress following marital separation interacts with a polymorphism in the serotonin transporter gene to predict cardiac vagal control in the laboratory

Psychophysiology

Volumn 52, Issue 6, 2015, Pages 736-744

  Hasselmo, Karen ^a   Sbarra, David A ^a   O'Connor, Mary Frances ^a   Moreno, Francisco A ^b  

^a The University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Divorce; Heart rate variability; Marital separation; Respiratory sinus arrhythmia; Serotonin transporter gene (5 HTTLPR); Single nucleotide polymorphism

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ALLELE; AUTONOMIC NERVOUS SYSTEM; DIVORCE; EMOTION; FEMALE; GENETICS; GENOTYPE; HUMAN; MALE; MENTAL STRESS; MIDDLE AGED; PHYSIOLOGY; PSYCHOLOGY; RESPIRATORY SINUS ARRHYTHMIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; AUTONOMIC NERVOUS SYSTEM; DIVORCE; EMOTIONS; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RESPIRATORY SINUS ARRHYTHMIA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL;

EID: 84929519736     PISSN: 00485772     EISSN: 14698986     Source Type: Journal    
DOI: 10.1111/psyp.12409     Document Type: Article

References (59)

1. Allen, J. J., Chambers, A. S., & Towers, D. N. (2007). The many metrics of cardiac chronotropy: A pragmatic primer and a brief comparison of metrics. Biological Psychology, 74, 243-262. doi:10.1016/j.biopsycho.2006.08.005
2. Anchodoquy, C., McGeary, C., Liu, L., & Krauter, K. S. (2003). Genotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cells. Behavior Genetics, 33, 73-77.
3. Austin, M. A., Riniolo, T. C., & Porges, S. W. (2007). Borderline personality disorder and emotion regulation: Insights from the polyvagal theory. Brain and Cognition, 65, 69-76. doi:10.1016/j.bandc.2006.05.007
4. Beauchaine, T. (2001). Vagal tone, development, and Gray's motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology. Development and Psychopathology, 13, 183-214. doi:10.1017/S0954579401002012
5. Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885-908. doi:10.1037/a0017376
6. Berntson, G. G., Bigger, T., Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., ... Van der Molen, M. (1997). Heart rate variability: Origins, methods, and interpretive caveats. Psychophysiology, 34, 623-648.
7. Berntson, G. G., Cacioppo, J. T., & Quigley, K. S. (1993). The metrics of cardiac chronotropism: Biometric perspectives. Psychophysiology, 32, 162-171. doi:10.1111/j.1469-8986.1995.tb03308.x
8. Brook, R. D., & Julius, S. (2000). Autonomic imbalance, hypertension, and cardiovascular risk. American Journal of Hypertension, 13, 112S-122S. doi:10.1016/S0895-7061(00)00228-4
9. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., ... Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the HTT gene. Science, 301, 386-389.
10. Coan, J. A., Allen, J. J., & McKnight, P. E. (2006) A capability model of individual differences in frontal EEG asymmetry. Biological Psychology, 72, 198-207. doi:10.1016/j.biopsycho.2005.10.003
11. Creamer, M., Bell, R., & Failla, S. (2003). Psychometric properties of the Impact of Event Scale-revised. Behaviour Research and Therapy, 41, 1489-1496. doi:10.1016/j.brat.2003.07.010
12. Dick, D. M., Agrawal, A., Keller, M. C., Adkins, A., Aliev, F., Monroe, S., ... Sher, K. J. (in press). Candidate gene-environment interaction research: Reflections and recommendations. Perspectives on Psychological Science.
13. Ehli, E. A., Hu, Y., Lengyel-Nelson, T., Hudziak, J. J., & Davies, G. E. (2012). Identification and functional characterization of three novel alleles for the serotonin transporter-linked polymorphic region. Molecular Psychiatry, 17, 185-192. doi:10.1038/mp.2010.130
14. Ellis, A., Beevers, C., Hixon, J. G., & McGeary, J. E. (2011). Serotonin transporter promoter region (5-HTTLPR) polymorphism predicts respiratory sinus arrhythmia. Psychophysiology, 48, 923-926. doi:10.1111/j.1469-8986.2010.01154.x
15. Frazier, T. W., Strauss, M. E., & Steinhauer, S. R. (2004). Respiratory sinus arrhythmia as an index of emotional response in young adults. Psychophysiology, 41, 75-83. doi:10.1046/j.1469-8986.2003.00131.x
16. Gelernter, J., Kranzler, H., & Cubells, J. F. (1997). Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African and European American and in Japanese populations, and in alcohol dependent subjects. Human Genetics, 10, 243-246. doi:10.1007/s004390050624
17. Gianaros, P. J., Salomon, K., Zhou, F., Owens, J. F., Edmundowicz, D., Kuller, L. H., & Matthews, K. A. (2005). A greater reduction in high-frequency heart rate variability to a psychological stressor is associated with subclinical coronary and aortic calcification in postmenopausal women. Psychosomatic Medicine, 67, 553-560. doi:10.1097/01.psy.0000170335.92770.7a
18. Haase, C. M., Saslow, L. R., Bloch, L., Saturn, S. R., Casey, J., Seider, B. H., ... Levenson, R. W. (2013). The 5-HTTLPR polymorphism in the serotonin transporter gene moderates the association between emotional behavior and changes in marital satisfaction over time. Emotion, 13, 1068-1079. doi:10.1037/a0033761
19. Hayano, J., Sakakibara, Y., Yamada, A., Yamada, M., Mukai, S., Fujinami, T., ... Takata, K. (1991). Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects. American Journal of Cardiology, 67, 199-204. doi:10.1016/0002-9149(91)90445-Q
20. Hu, X. Z., Lipsky, R. H., Zhu, G., Akhtar, L. A., Taubman, J., Greenberg, B. D., ... Goldman, D. (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. American Journal of Human Genetics, 78, 815-826. doi:10.1086/503850
21. Jenness, J. L., Hankin, B. L., Abela, J. R. Z., Young, J. F., & Smolen, A. (2011). Chronic family stress interacts with 5-HTTLPR to predict prospective depressive symptoms among youth. Depression and Anxiety, 28, 1074-1080. doi:10.1002/da.20904
22. Judd, C. M., McClelland, G. H., & Culhane, S. E. (1995). Data analysis: Continuing issues in the everyday analysis of psychological data. Annual Review of Psychology, 46, 433-465. doi:10.1146/annurev.psych.46.1.433
23. Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444-454. doi:10.1001/archgenpsychiatry.2010.189
24. Kleiger, R. E., Miller, J. P., Bigger, J. T., & Moss, A. J. (1987). Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. American Journal of Cardiology, 59, 256-262. doi:10.1016/0002-9149(87)90795-8
25. Lee, L. A., Sbarra, D. A., Mason, A. E., & Law, R. W. (2011). Attachment anxiety, verbal immediacy, and blood pressure: Results from a laboratory analog study following marital separation. Personal Relationships, 18, 285-301. doi:10.1111/j.1475-6811.2011.01360.x
26. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., ... Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531. doi:10.1126/science.274.5292.1527
27. Luan, J. A., Wong, M. Y., Day, N. E., & Wareham, N. J. (2001). Sample size determination for studies of gene-environment interaction. International Epidemiological Association, 30, 1035-1040. doi:10.1093/ije/30.5.1035
28. Masi, C. M., Hawkley, L. C., Rickett, E. M., & Cacioppo, J. T. (2007). Respiratory sinus arrhythmia and diseases of aging: Obesity, diabetes mellitus, and hypertension. Biological Psychology, 74, 212-223. doi:10.1016/j.biopsycho.2006.07.006
29. Mason, A. E., & Sbarra, D. A. (2012). Romantic separation, loss, and health: A review of moderators. In M. Newman & N. Roberts (Eds.), The handbook of health and social relationships (pp. 95-120). Washington, DC: American Psychological Association. doi:10.1037/14036-005
30. McEwen, B. S. (1998). Stress, adaptation, and disease: Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 33-44. doi:10.1111/j.1749-6632.1998.tb09546.x
31. Moffitt, T. E., Caspi, A., & Rutter, M. (2006). Measured gene-environment interactions in psychopathology concepts, research strategies, and implications for research, intervention, and public understanding of genetics. Perspectives on Psychological Science, 1, 5-27. doi:10.1111/j.1745-6916.2006.00002.x
32. Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders. Psychological Bulletin, 110, 406-425. doi:10.1037/0033-2909.110.3.406
33. Movius, H. L., & Allen, J. J. (2005). Cardiac vagal tone, defensiveness, and motivational style. Biological Psychology, 68, 147-162. doi.10.1016/j.biopsycho.2004.03.019
34. Nakamura, M., Ueno, S., Sano, A., & Tanabe, H. (2000). The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Molecular Psychiatry, 5, 32-38. doi:10.1038/sj.mp.4000698
35. O'Connor, M.-F., Motivala, S., Valladares, E. M., Olmstead, R., & Irwin, M. (2007). Sex differences in monocyte expression of IL-6: Role of autonomic mechanisms. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 293, R145-R151. doi:10.1152/ajpregu.00752.2006
36. Plomin, R., DeFries, J. C., & Loehlin, J. C. (1977). Genotype-environment interact and correlation in the analysis of human behavior. Psychological Bulletin, 84, 309-322. doi:10.1037/0033-2909.84.2.309
37. Porges, S. W. (1995). Orienting in a defensive world: Mammalian modifications of our evolutionary heritage. A polyvagal theory. Psychophysiology, 32, 301-318. doi:10.1111/j.1469-8986.1995.tb01213.x
38. Porges, S. W. (1997). Emotion: An evolutionary by-product of the neural regulation of the autonomic nervous system. Annals of the New York Academy of Sciences, 807, 62-77. doi:10.1111/j.1749-6632.1997.tb51913.x
39. Porges, S. W. (2007). The polyvagal perspective. Biological Psychology, 74, 116-143. doi:10.1016/j.biopsycho.2006.06.009
40. Praschak-Rieder, N., Kennedy, J., Wilson, A. A., Hussey, D., Boovariwala, A., Willeit, M., ... Meyer, J. H. (2007). Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: A [(11)C] DASB positron emission tomography study. Biological Psychiatry, 62, 327-331.
41. Rottenberg, J., Salomon, K., Gross, J. A., & Gotlib, I. H. (2005). Vagal withdrawal to a sad film predicts subsequent recovery from depression. Psychophysiology, 42, 277-281. doi:10.1111/j.1469-8986.2005.00289.x
42. Sbarra, D. A., & Coan, J. A. (2013). Theory, method, and prediction in the psychophysiology of relationships. International Journal of Psychophysiology, 88, 219-223. doi:10.1016/j.ijpsycho.2013.05.014
43. Sbarra, D. A., Emery, R. E., Beam, C. R., & Ocker, B. L. (2013). Marital dissolution and major depression in midlife: A propensity score analysis. Clinical Psychological Science, 1-9. doi:10.1177/2167702613498727
44. Sbarra, D. A., Hasselmo, K., & Nojopranoto, W. (2012). Divorce and death: A case study for health psychology. Social and Personality Psychology Compass, 6, 905-919. doi:10.1111/spc3.12002
45. Sbarra, D. A., Law, R. W., Lee, L. A., & Mason, A. E. (2009). Marital dissolution and blood pressure reactivity: Evidence for the specificity of emotional intrusion-hyperarousal and task-rated emotional difficulty. Psychosomatic Medicine, 71, 532-540.
46. Sbarra, D. A., Law, R. W., & Portley, R. M. (2011). Divorce and death: A meta-analysis and research agenda for clinical, social, and health psychology. Perspectives on Psychological Science, 6, 454-474. doi:10.1177/1745691611414724
47. Schoebi, D., Way, B. M., Karney, B. R., & Bradbury, T. N. (2012). Genetic moderation of sensitivity to positive and negative affect in marriage. Emotion, 12, 208-212. doi:10.1037/a0026067
48. Sgoutas-Emch, S. A., Cacioppo, J. T., Uchino, B. N., Malarkey, W., Pearl, D., Kiecolt-Glaser, J. K., & Glaser, R. (1994). The effects of an acute psychological stressor on cardiovascular, endocrine, and cellular immune response: A prospective study of individuals high and low in heart rate reactivity. Psychophysiology, 31, 264-271. doi:10.1111/j.1469-8986.1994.tb02215.x
49. Stein, P. K., & Kleiger, R. E. (1999). Insights from the study of heart rate variability. Annual Review of Medicine, 50, 249-261.
50. Taylor, S. E., Way, B. M., Welch, W. T., Hilmert, C. J., Lehman, B. J., & Eisenberger, N. I. (2006.) Family environment, current adversity, the serotonin transporter promotor polymorphism, and depressive symptomology. Biological Psychiatry, 60, 671-676. doi:10.1016/j.biopsych.2006.04.019
51. Thayer, J. F., Friedman, B. H., & Borkovec, T. D. (1996). Autonomic characteristics of generalized anxiety disorder and worry. Biological Psychiatry, 39, 255-266. doi:10.1016/0006-3223(95)00136-0
52. Thayer, J. F., & Lane, R. D. (2005). The importance of inhibition in dynamical systems models of emotion and neurobiology. Behavioral and Brain Sciences, 28, 218-219. doi:10.1017/S0140525X05470041
53. Treiber, F. A., Kamarck, T., Schneiderman, N., Sheffield, D., Kapuku, G., & Taylor, T. (2003). Cardiovascular reactivity and development of preclinical and clinical disease states. Psychosomatic Medicine, 65, 46-62. doi:10.1097/00006842-200301000-00007
54. von Kanel, R., Carney, R. M., Zhao, S., & Whooley, M. A. (2012). Heart rate variability and biomarkers of systemic inflammation in patients with stable coronary heart disease: findings from the Heart and Soul Study. Clinical Research in Cardiology, 100, 241-247. doi:10.1007/s00392-010-0236-5
55. Vrshek-Schallhorn, S., Mineka, S., Zinbarg, R. E., Craske, M. G., Griffith, J. W., Sutton, J., ... Adam, E. K. (2013). Refining the candidate environment interpersonal stress, the serotonin transporter polymorphism, and gene-environment interactions in major depression. Clinical Psychological Science, 2, 235-248. Advance online publication. doi:10.1177/2167702613499329
56. Vulturar, R., Chis, A., Ungureanu, L., & Miu, A. C. (2012). Respiratory sinus arrhythmia and serotonin transporter promoter polymorphisms: Taking a triallelic approach makes a difference. Psychophysiology, 49, 1412-1416. doi:10.1111/j.1469-8986.2012.01445.x
57. Weiss, D. S., & Marmar, C. R. (1997). The Impact of Events Scale-revised. In J. P Wilson & T. M. Keane (Eds.), Assessing psychological trauma and PTSD (pp. 399-411). New York, NY: Guildford. doi:10.1007/978-0-387-70990-1_10
58. Williams, R. B. (1994). Neurobiology, cellular and molecular biology, and psychosomatic medicine. Psychosomatic Medicine, 56, 308-315. doi:10.1016/j.jrp.2011.08.009
59. Williams, R. B., Marchuk, D. A., Gadde, K. M., Barefoot, J. C., Grichnik, K., Helms, M. J., ... Siegler, I. C. (2003). Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology, 28, 533-541.