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Volumn 10, Issue 4, 2015, Pages 469-478

Pharmacological treatment and prevention of cerebral small vessel disease: A review of potential interventions

Author keywords

Antithrombotics; Blood brain barrier; Blood pressure lowering; Cyclic nucleotide inhibitors; Nitric oxide; Prostacyclin

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTITHROMBOCYTIC AGENT; CHOLINESTERASE INHIBITOR; CYCLIC GMP; ENDOTHELIN; IMMUNOSUPPRESSIVE AGENT; NEUROTROPHIN; NITRIC OXIDE; NOOTROPIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PHOSPHODIESTERASE V INHIBITOR; RHO KINASE INHIBITOR; VITAMIN; XANTHINE OXIDASE INHIBITOR;

EID: 84929519122     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/ijs.12466     Document Type: Article
Times cited : (145)

References (66)
  • 2
    • 77953533246 scopus 로고    scopus 로고
    • Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges
    • Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010; 9:689-701.
    • (2010) Lancet Neurol , vol.9 , pp. 689-701
    • Pantoni, L.1
  • 3
    • 84880391350 scopus 로고    scopus 로고
    • Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
    • Wardlaw JM, Smith EE, Biessels GJ etal. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013; 12:822-838.
    • (2013) Lancet Neurol , vol.12 , pp. 822-838
    • Wardlaw, J.M.1    Smith, E.E.2    Biessels, G.J.3
  • 4
    • 84894166022 scopus 로고    scopus 로고
    • Advancements in understanding the mechanisms of symptomatic lacunar ischemic stroke: Translation of knowledge to prevention strategies
    • Arboix A, Blanco-Rojas L, Marti-Vilalta J. Advancements in understanding the mechanisms of symptomatic lacunar ischemic stroke: translation of knowledge to prevention strategies. Expert Rev Neurother 2014; 14:261-276.
    • (2014) Expert Rev Neurother , vol.14 , pp. 261-276
    • Arboix, A.1    Blanco-Rojas, L.2    Marti-Vilalta, J.3
  • 5
    • 73449115650 scopus 로고    scopus 로고
    • Differences between ischemic stroke subtypes in vascular outcomes support a distinct lacunar ischemic stroke arteriopathy: a prospective, hospital-based study
    • Jackson CA, Hutchison A, Dennis MS, Wardlaw JM, Lewis SC, Sudlow CL. Differences between ischemic stroke subtypes in vascular outcomes support a distinct lacunar ischemic stroke arteriopathy: a prospective, hospital-based study. Stroke 2009; 40:3679-3684.
    • (2009) Stroke , vol.40 , pp. 3679-3684
    • Jackson, C.A.1    Hutchison, A.2    Dennis, M.S.3    Wardlaw, J.M.4    Lewis, S.C.5    Sudlow, C.L.6
  • 6
    • 84879923518 scopus 로고    scopus 로고
    • Cognitive impairment after lacunar stroke: systematic review and meta-analysis of incidence, prevalence and comparison with other stroke subtypes
    • Makin SD, Turpin S, Dennis MS, Wardlaw JM. Cognitive impairment after lacunar stroke: systematic review and meta-analysis of incidence, prevalence and comparison with other stroke subtypes. J Neurol Neurosurg Psychiatry 2013; 84:893-900.
    • (2013) J Neurol Neurosurg Psychiatry , vol.84 , pp. 893-900
    • Makin, S.D.1    Turpin, S.2    Dennis, M.S.3    Wardlaw, J.M.4
  • 7
    • 84860220960 scopus 로고    scopus 로고
    • Covert neurological symptoms associated with silent infarcts from midlife to older age: the Atherosclerosis Risk in Communities study
    • Windham BG, Griswold ME, Shibata D, Penman A, Catellier DJ, Mosley TH Jr. Covert neurological symptoms associated with silent infarcts from midlife to older age: the Atherosclerosis Risk in Communities study. Stroke 2012; 43:1218-1223.
    • (2012) Stroke , vol.43 , pp. 1218-1223
    • Windham, B.G.1    Griswold, M.E.2    Shibata, D.3    Penman, A.4    Catellier, D.J.5    Mosley Jr, T.H.6
  • 8
    • 78650024252 scopus 로고    scopus 로고
    • White matter hyperintensity volume is increased in small vessel stroke subtypes
    • Rost NS, Rahman RM, Biffi A etal. White matter hyperintensity volume is increased in small vessel stroke subtypes. Neurology 2010; 75:1670-1677.
    • (2010) Neurology , vol.75 , pp. 1670-1677
    • Rost, N.S.1    Rahman, R.M.2    Biffi, A.3
  • 9
    • 33749022209 scopus 로고    scopus 로고
    • Cerebral microbleeds are associated with lacunar stroke defined clinically and radiologically, independently of white matter lesions
    • Wardlaw JM, Lewis SC, Keir SL, Dennis MS, Shenkin S. Cerebral microbleeds are associated with lacunar stroke defined clinically and radiologically, independently of white matter lesions. Stroke 2006; 37:2633-2636.
    • (2006) Stroke , vol.37 , pp. 2633-2636
    • Wardlaw, J.M.1    Lewis, S.C.2    Keir, S.L.3    Dennis, M.S.4    Shenkin, S.5
  • 10
    • 77449112819 scopus 로고    scopus 로고
    • Counting cavitating lacunes underestimates the burden of lacunar infarction
    • Potter GM, Doubal FN, Jackson CA etal. Counting cavitating lacunes underestimates the burden of lacunar infarction. Stroke 2010; 41:267-272.
    • (2010) Stroke , vol.41 , pp. 267-272
    • Potter, G.M.1    Doubal, F.N.2    Jackson, C.A.3
  • 11
    • 77955360281 scopus 로고    scopus 로고
    • The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis
    • Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2010; 341:c3666.
    • (2010) BMJ , vol.341 , pp. c3666
    • Debette, S.1    Markus, H.S.2
  • 14
    • 69949104474 scopus 로고    scopus 로고
    • Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis
    • Morris Z, Whiteley WN, Longstreth WT Jr etal. Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2009; 339:b3016.
    • (2009) BMJ , vol.339 , pp. b3016
    • Morris, Z.1    Whiteley, W.N.2    Longstreth Jr, W.T.3
  • 15
    • 84890260907 scopus 로고    scopus 로고
    • Cognitive profile in patients with a first-ever lacunar infarct with and without silent lacunes: a comparative study
    • Blanco-Rojas L, Arboix A, Canovas D, Grau-Olivares M, Morera J, Parra O. Cognitive profile in patients with a first-ever lacunar infarct with and without silent lacunes: a comparative study. BMC Neurol 2013; 13:203.
    • (2013) BMC Neurol , vol.13 , pp. 203
    • Blanco-Rojas, L.1    Arboix, A.2    Canovas, D.3    Grau-Olivares, M.4    Morera, J.5    Parra, O.6
  • 16
    • 84878586224 scopus 로고
    • Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort
    • Aribisala B, Valdes Hernandez M, Royle N etal. Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort. Eur Radiol 1936; 23:1084-1092.
    • (1936) Eur Radiol , vol.23 , pp. 1084-1092
    • Aribisala, B.1    Valdes Hernandez, M.2    Royle, N.3
  • 17
    • 84871216609 scopus 로고    scopus 로고
    • Incident subcortical infarcts induce focal thinning in connected cortical regions
    • Duering M, Righart R, Csanadi E etal. Incident subcortical infarcts induce focal thinning in connected cortical regions. Neurology 2012; 79:2025-2028.
    • (2012) Neurology , vol.79 , pp. 2025-2028
    • Duering, M.1    Righart, R.2    Csanadi, E.3
  • 19
    • 41049104686 scopus 로고    scopus 로고
    • Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians
    • Qaseem A, Snow V, Cross JT Jr etal. Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Ann Intern Med 2008; 148:370-378.
    • (2008) Ann Intern Med , vol.148 , pp. 370-378
    • Qaseem, A.1    Snow, V.2    Cross Jr, J.T.3
  • 20
    • 84888293767 scopus 로고    scopus 로고
    • Variation in risk factors for recent small subcortical infarcts with infarct size, shape, and location
    • Bene A, Makin S, Doubal F, Inzitari D, Wardlaw J. Variation in risk factors for recent small subcortical infarcts with infarct size, shape, and location. Stroke 2013; 44:3000-3006.
    • (2013) Stroke , vol.44 , pp. 3000-3006
    • Bene, A.1    Makin, S.2    Doubal, F.3    Inzitari, D.4    Wardlaw, J.5
  • 21
    • 0043166526 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease
    • Topol E, Easton D, Harrington R etal. Randomised, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease. Am Heart Assoc 2003; 108:399-406.
    • (2003) Am Heart Assoc , vol.108 , pp. 399-406
    • Topol, E.1    Easton, D.2    Harrington, R.3
  • 23
    • 84864189489 scopus 로고    scopus 로고
    • Effect of addition of clopidogrel to aspirin on mortality: systematic review of randomized trials
    • Palacio S, Hart RG, Pearce LA, Benavente OR. Effect of addition of clopidogrel to aspirin on mortality: systematic review of randomized trials. Stroke 2012; 43:2157-2162.
    • (2012) Stroke , vol.43 , pp. 2157-2162
    • Palacio, S.1    Hart, R.G.2    Pearce, L.A.3    Benavente, O.R.4
  • 24
    • 84859555815 scopus 로고    scopus 로고
    • Vorapaxar in the secondary prevention of atherothrombotic events
    • Morrow D, Braunwald M, Bonaca M etal. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 2012; 366:1404-1413.
    • (2012) N Engl J Med , vol.366 , pp. 1404-1413
    • Morrow, D.1    Braunwald, M.2    Bonaca, M.3
  • 25
    • 0031809284 scopus 로고    scopus 로고
    • Von Willebrand factor, p-selectin and fibrinogen levels in patients with acute ischaemic and haemorrhagic stroke, and their relationship with stroke sub-type and functional outcome
    • Bath PMW, Blann A, Smith N, Butterworth RJ. Von Willebrand factor, p-selectin and fibrinogen levels in patients with acute ischaemic and haemorrhagic stroke, and their relationship with stroke sub-type and functional outcome. Platelets 1998; 9:155-159.
    • (1998) Platelets , vol.9 , pp. 155-159
    • Bath, P.M.W.1    Blann, A.2    Smith, N.3    Butterworth, R.J.4
  • 26
    • 84885599180 scopus 로고    scopus 로고
    • Circulating markers of endothelial dysfunction and platelet activation in patients with severe symptomatic cerebral small vessel disease
    • Lavallee PC, Labreuche J, Faille D etal. Circulating markers of endothelial dysfunction and platelet activation in patients with severe symptomatic cerebral small vessel disease. Cerebrovasc Dis 2013; 36:131-138.
    • (2013) Cerebrovasc Dis , vol.36 , pp. 131-138
    • Lavallee, P.C.1    Labreuche, J.2    Faille, D.3
  • 27
    • 65449158394 scopus 로고    scopus 로고
    • Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood-brain barrier ghypermeability
    • Allen CL, Bayraktutan U. Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood-brain barrier ghypermeability. Diabetes Obes Metab 2009; 11:480-490.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 480-490
    • Allen, C.L.1    Bayraktutan, U.2
  • 28
    • 77956410740 scopus 로고    scopus 로고
    • Small GTPase RhoA and its effector rho kinase mediate oxygen glucose deprivation-evoked in vitro cerebral barrier dysfunction
    • Allen C, Srivastava K, Bayraktutan U. Small GTPase RhoA and its effector rho kinase mediate oxygen glucose deprivation-evoked in vitro cerebral barrier dysfunction. Stroke 2010; 41:2056-2063.
    • (2010) Stroke , vol.41 , pp. 2056-2063
    • Allen, C.1    Srivastava, K.2    Bayraktutan, U.3
  • 29
    • 84885299035 scopus 로고    scopus 로고
    • Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-beta
    • Shao B, Bayraktutan U. Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-beta. Diabetes Obes Metab 2013; 15:993-999.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 993-999
    • Shao, B.1    Bayraktutan, U.2
  • 30
    • 58549098084 scopus 로고    scopus 로고
    • Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis
    • Farrall AJ, Wardlaw JM. Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis. Neurobiol Aging 2009; 30:337-352.
    • (2009) Neurobiol Aging , vol.30 , pp. 337-352
    • Farrall, A.J.1    Wardlaw, J.M.2
  • 31
    • 84919340367 scopus 로고    scopus 로고
    • Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial
    • Pearce LA, McClure LA, Anderson DC etal. Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial. Lancet Neurol 2014; 13:1177-1185.
    • (2014) Lancet Neurol , vol.13 , pp. 1177-1185
    • Pearce, L.A.1    McClure, L.A.2    Anderson, D.C.3
  • 32
    • 81255125338 scopus 로고    scopus 로고
    • Level of systolic blood pressure within the normal range and risk of recurrent stroke
    • Ovbiagele B, Diener H-C, Yusuf S etal. Level of systolic blood pressure within the normal range and risk of recurrent stroke. JAMA 2011; 306:2137-2144.
    • (2011) JAMA , vol.306 , pp. 2137-2144
    • Ovbiagele, B.1    Diener, H.-C.2    Yusuf, S.3
  • 33
    • 84872083948 scopus 로고    scopus 로고
    • High blood pressure, physical and cognitive function, and risk of stroke in the oldest old: the Leiden 85-plus Study
    • Sabayan B, van Vliet P, de Ruijter W, Gussekloo J, de Craen AJ, Westendorp RG. High blood pressure, physical and cognitive function, and risk of stroke in the oldest old: the Leiden 85-plus Study. Stroke 2013; 44:15-20.
    • (2013) Stroke , vol.44 , pp. 15-20
    • Sabayan, B.1    van Vliet, P.2    de Ruijter, W.3    Gussekloo, J.4    de Craen, A.J.5    Westendorp, R.G.6
  • 34
    • 84869127972 scopus 로고    scopus 로고
    • Impact of resting heart rate on mortality, disability and cognitive decline in patients after ischaemic stroke
    • Bohm M, Cotton D, Foster L etal. Impact of resting heart rate on mortality, disability and cognitive decline in patients after ischaemic stroke. Eur Heart J 2012; 33:2804-2812.
    • (2012) Eur Heart J , vol.33 , pp. 2804-2812
    • Bohm, M.1    Cotton, D.2    Foster, L.3
  • 35
    • 77749251836 scopus 로고    scopus 로고
    • Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
    • Rothwell PM, Howard SC, Dolan E etal. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375:895-905.
    • (2010) Lancet , vol.375 , pp. 895-905
    • Rothwell, P.M.1    Howard, S.C.2    Dolan, E.3
  • 36
    • 56649103770 scopus 로고    scopus 로고
    • Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review
    • Hainsworth AH, Markus HS. Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review. J Cereb Blood Flow Metab 2008; 28:1877-1891.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1877-1891
    • Hainsworth, A.H.1    Markus, H.S.2
  • 37
    • 66849101991 scopus 로고    scopus 로고
    • Potential animal models of lacunar stroke: a systematic review
    • Bailey EL, McCulloch J, Sudlow C, Wardlaw JM. Potential animal models of lacunar stroke: a systematic review. Stroke 2009; 40:e451-458.
    • (2009) Stroke , vol.40 , pp. e451-e458
    • Bailey, E.L.1    McCulloch, J.2    Sudlow, C.3    Wardlaw, J.M.4
  • 38
    • 0026582639 scopus 로고
    • Effect of systemic L-arginine administration on hemodynamics and nitric oxide release in man
    • Hishikawa K, Nakaki T, Tsuda M etal. Effect of systemic L-arginine administration on hemodynamics and nitric oxide release in man. Jpn Heart J 1992; 33:41-48.
    • (1992) Jpn Heart J , vol.33 , pp. 41-48
    • Hishikawa, K.1    Nakaki, T.2    Tsuda, M.3
  • 39
    • 33845877743 scopus 로고    scopus 로고
    • Effects of dietary nitrate on blood pressure in health volunteers
    • Larsen FJ, Lundberg JO. Effects of dietary nitrate on blood pressure in health volunteers. NEJM 2006; 355:2792-2793.
    • (2006) NEJM , vol.355 , pp. 2792-2793
    • Larsen, F.J.1    Lundberg, J.O.2
  • 40
    • 79251626326 scopus 로고    scopus 로고
    • Acute effect of a high nitrate diet on brain perfusion in older adults
    • Presley TD, Morgan AR, Bechtold E etal. Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide 2011; 24:34-42.
    • (2011) Nitric Oxide , vol.24 , pp. 34-42
    • Presley, T.D.1    Morgan, A.R.2    Bechtold, E.3
  • 41
    • 0027236094 scopus 로고
    • L-arginine infusion has no effect on systemic haemodynamics in normal volunteers, or systemic and pulmonary haemodynamics in patients with elevated pulmonary vascular resistance
    • Baudouin SV, Bath P, Martin JF, Du Bois R, Evans TW. L-arginine infusion has no effect on systemic haemodynamics in normal volunteers, or systemic and pulmonary haemodynamics in patients with elevated pulmonary vascular resistance. Br J Clin Pharmacol 1993; 36:45-49.
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 45-49
    • Baudouin, S.V.1    Bath, P.2    Martin, J.F.3    Du Bois, R.4    Evans, T.W.5
  • 42
    • 0344520206 scopus 로고    scopus 로고
    • Plasma nitric oxide (nitrate/nitrite) levels in acute stroke and their relationship with severity and outcome
    • Rashid PA, Whitehurst A, Lawson N, Bath PMW. Plasma nitric oxide (nitrate/nitrite) levels in acute stroke and their relationship with severity and outcome. J Stroke Cerebrovasc Dis 2003; 12:82-87.
    • (2003) J Stroke Cerebrovasc Dis , vol.12 , pp. 82-87
    • Rashid, P.A.1    Whitehurst, A.2    Lawson, N.3    Bath, P.M.W.4
  • 43
    • 0032019514 scopus 로고    scopus 로고
    • Nitric oxide plasma levels in patients with chronic and acute cerebrovascular disorders
    • Ferlito S, Gallina M, Pitari GM, Bianchi A. Nitric oxide plasma levels in patients with chronic and acute cerebrovascular disorders. Panminerva Med 1998; 40:51-54.
    • (1998) Panminerva Med , vol.40 , pp. 51-54
    • Ferlito, S.1    Gallina, M.2    Pitari, G.M.3    Bianchi, A.4
  • 44
    • 80052617136 scopus 로고    scopus 로고
    • Anti-platelet therapy: phosphodiesterase inhibitors
    • Gresele P, Momi S, Falcinelli E. Anti-platelet therapy: phosphodiesterase inhibitors. Br J Clin Pharmacol 2011; 72:634-646.
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 634-646
    • Gresele, P.1    Momi, S.2    Falcinelli, E.3
  • 45
    • 84908661465 scopus 로고    scopus 로고
    • Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis
    • Davidai G, Cotton D, Gorelick P etal. Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis. Eur J Neurol 2014; 21:1311-1317.
    • (2014) Eur J Neurol , vol.21 , pp. 1311-1317
    • Davidai, G.1    Cotton, D.2    Gorelick, P.3
  • 46
    • 0032544181 scopus 로고    scopus 로고
    • Cilostazol has beneficial effects in treatment of intermittent clauidication
    • Dawson DL, Cutler BS, Meissner MH, Strandness DE. Cilostazol has beneficial effects in treatment of intermittent clauidication. Circulation 1998; 98:678-686.
    • (1998) Circulation , vol.98 , pp. 678-686
    • Dawson, D.L.1    Cutler, B.S.2    Meissner, M.H.3    Strandness, D.E.4
  • 47
    • 84868236705 scopus 로고    scopus 로고
    • Effect of cilostazol in acute lacunar infarction based on pulsatility index of transcranial Doppler (ECLIPse): a multicenter, randomized, double-blind, placebo-controlled trial
    • Han SW, Lee SS, Kim SH etal. Effect of cilostazol in acute lacunar infarction based on pulsatility index of transcranial Doppler (ECLIPse): a multicenter, randomized, double-blind, placebo-controlled trial. Eur Neurol 2013; 69:33-40.
    • (2013) Eur Neurol , vol.69 , pp. 33-40
    • Han, S.W.1    Lee, S.S.2    Kim, S.H.3
  • 48
    • 84870295059 scopus 로고    scopus 로고
    • Effect of cilostazol in the treatment of acute ischemic stroke in the lenticulostriate artery territory
    • Kondo R, Matsumoto Y, Furui E etal. Effect of cilostazol in the treatment of acute ischemic stroke in the lenticulostriate artery territory. Eur Neurol 2013; 69:122-128.
    • (2013) Eur Neurol , vol.69 , pp. 122-128
    • Kondo, R.1    Matsumoto, Y.2    Furui, E.3
  • 49
    • 76349109248 scopus 로고    scopus 로고
    • Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain
    • Miyamoto N, Tanaka R, Shimura H etal. Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain. J Cereb Blood Flow Metab 2010; 30:299-310.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 299-310
    • Miyamoto, N.1    Tanaka, R.2    Shimura, H.3
  • 50
    • 84861591193 scopus 로고    scopus 로고
    • Clinical and pathological improvement in stroke-prone spontaneous hypertensive rats related to the pleiotropic effect of cilostazol
    • Omote Y, Deguchi K, Tian F etal. Clinical and pathological improvement in stroke-prone spontaneous hypertensive rats related to the pleiotropic effect of cilostazol. Stroke 2012; 43:1639-1646.
    • (2012) Stroke , vol.43 , pp. 1639-1646
    • Omote, Y.1    Deguchi, K.2    Tian, F.3
  • 51
    • 27644505297 scopus 로고    scopus 로고
    • Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial
    • Shibuya M, Hirai S, Seto M, Satoh S, Ohtomo E. Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. J Neurol Sci 2005; 238:31-39.
    • (2005) J Neurol Sci , vol.238 , pp. 31-39
    • Shibuya, M.1    Hirai, S.2    Seto, M.3    Satoh, S.4    Ohtomo, E.5
  • 52
    • 84881442965 scopus 로고    scopus 로고
    • Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts
    • Palmer TM, Nordestgaard BG, Benn M etal. Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts. BMJ 2013; 347:f4262.
    • (2013) BMJ , vol.347 , pp. f4262
    • Palmer, T.M.1    Nordestgaard, B.G.2    Benn, M.3
  • 53
    • 84920678215 scopus 로고    scopus 로고
    • Post-stroke cognitive decline: an update and persepctives for clinical research
    • Brainin M, Tuomilehto J, Heiss W-D etal. Post-stroke cognitive decline: an update and persepctives for clinical research. Eur J Neurol 2015; 22:229-238.
    • (2015) Eur J Neurol , vol.22 , pp. 229-238
    • Brainin, M.1    Tuomilehto, J.2    Heiss, W.-D.3
  • 54
    • 84859313679 scopus 로고    scopus 로고
    • Dietary flavonoids and risk of stroke in women
    • Cassidy A, Rimm EB, O'Reilly EJ etal. Dietary flavonoids and risk of stroke in women. Stroke 2012; 43:946-951.
    • (2012) Stroke , vol.43 , pp. 946-951
    • Cassidy, A.1    Rimm, E.B.2    O'Reilly, E.J.3
  • 55
    • 84870602273 scopus 로고    scopus 로고
    • Relationship between healthy diet and risk of cardiovascular disease among patients on drug therapies for secondary prevention: a prospective cohort study of 31 546 high-risk individuals from 40 countries
    • Dehghan M, Mente A, Teo KK etal. Relationship between healthy diet and risk of cardiovascular disease among patients on drug therapies for secondary prevention: a prospective cohort study of 31 546 high-risk individuals from 40 countries. Circulation 2012; 126:2705-2712.
    • (2012) Circulation , vol.126 , pp. 2705-2712
    • Dehghan, M.1    Mente, A.2    Teo, K.K.3
  • 56
    • 84858246514 scopus 로고    scopus 로고
    • The effectiveness of secondary prevention lifestyle interventions designed to change lifestyle behavior following stroke: summary of a systematic review
    • Lawrence M, Kerr S, McVey C, Godwin J. The effectiveness of secondary prevention lifestyle interventions designed to change lifestyle behavior following stroke: summary of a systematic review. Int J Stroke 2012; 7:243-247.
    • (2012) Int J Stroke , vol.7 , pp. 243-247
    • Lawrence, M.1    Kerr, S.2    McVey, C.3    Godwin, J.4
  • 58
    • 70749114435 scopus 로고    scopus 로고
    • Low-Sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans
    • Al-Solaiman Y, Jesri A, Zhao Y, Morrow JD, Egan BM. Low-Sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans. J Hum Hypertens 2009; 23:826-835.
    • (2009) J Hum Hypertens , vol.23 , pp. 826-835
    • Al-Solaiman, Y.1    Jesri, A.2    Zhao, Y.3    Morrow, J.D.4    Egan, B.M.5
  • 59
    • 84880934609 scopus 로고    scopus 로고
    • A NO way to BOLD?: dietary nitrate alters the hemodynamic response to visual stimulation
    • Aamand R, Dalsgaard T, Ho YC, Moller A, Roepstorff A, Lund TE. A NO way to BOLD?: dietary nitrate alters the hemodynamic response to visual stimulation. Neuroimage 2013; 83C:397-407.
    • (2013) Neuroimage , vol.83 , pp. 397-407
    • Aamand, R.1    Dalsgaard, T.2    Ho, Y.C.3    Moller, A.4    Roepstorff, A.5    Lund, T.E.6
  • 60
    • 79957622596 scopus 로고    scopus 로고
    • Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial
    • Vadillo-Ortega F, Perichart-Perera O, Espino S etal. Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. BMJ 2011; 342:d2901.
    • (2011) BMJ , vol.342 , pp. d2901
    • Vadillo-Ortega, F.1    Perichart-Perera, O.2    Espino, S.3
  • 61
    • 84871659652 scopus 로고    scopus 로고
    • Prevention of post-stroke cognitive decline: a review focusing on lifestyle interventions
    • Teuschl Y, Matz K, Brainin M. Prevention of post-stroke cognitive decline: a review focusing on lifestyle interventions. Eur J Neurol 2013; 20:35-49.
    • (2013) Eur J Neurol , vol.20 , pp. 35-49
    • Teuschl, Y.1    Matz, K.2    Brainin, M.3
  • 62
    • 84881480372 scopus 로고    scopus 로고
    • Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial
    • Benavente OR, Coffey CS, Conwit R etal. Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. Lancet 2013; 382:507-515.
    • (2013) Lancet , vol.382 , pp. 507-515
    • Benavente, O.R.1    Coffey, C.S.2    Conwit, R.3
  • 63
    • 76749125377 scopus 로고    scopus 로고
    • Associations of clinical stroke misclassification ('clinical-imaging dissociation') in acute ischemic stroke
    • Potter G, Doubal F, Jackson C, Sudlow C, Dennis M, Wardlaw J. Associations of clinical stroke misclassification ('clinical-imaging dissociation') in acute ischemic stroke. Cerebrovasc Dis 2010; 29:395-402.
    • (2010) Cerebrovasc Dis , vol.29 , pp. 395-402
    • Potter, G.1    Doubal, F.2    Jackson, C.3    Sudlow, C.4    Dennis, M.5    Wardlaw, J.6
  • 64
    • 0027378741 scopus 로고
    • Effects of dipyridamole, pentoxifylline or dipyridamole plus pentoxifylline on platelet reactivity in patients with ischemic cerebrovascular insufficiency
    • Santos MT, Valles J, Aznar J, Yaya R, Perez-Requejo JL. Effects of dipyridamole, pentoxifylline or dipyridamole plus pentoxifylline on platelet reactivity in patients with ischemic cerebrovascular insufficiency. Thromb Res 1993; 72:219-229.
    • (1993) Thromb Res , vol.72 , pp. 219-229
    • Santos, M.T.1    Valles, J.2    Aznar, J.3    Yaya, R.4    Perez-Requejo, J.L.5
  • 65
    • 84867166941 scopus 로고    scopus 로고
    • Targeting phosphodiesterases in anti-platelet therapy
    • Rondina MT, Weyrich AS. Targeting phosphodiesterases in anti-platelet therapy. Handb Exp Pharmacol 2012; 210:225-238.
    • (2012) Handb Exp Pharmacol , vol.210 , pp. 225-238
    • Rondina, M.T.1    Weyrich, A.S.2
  • 66
    • 84867223079 scopus 로고    scopus 로고
    • Characterization of new organic nitrate hybrid drugs covalently bound to valsartan and cilostazol
    • Knorr M, Hausding M, Schulz E etal. Characterization of new organic nitrate hybrid drugs covalently bound to valsartan and cilostazol. Pharmacology 2012; 90:193-204.
    • (2012) Pharmacology , vol.90 , pp. 193-204
    • Knorr, M.1    Hausding, M.2    Schulz, E.3


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