Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm

Circulation

Volumn 131, Issue 11, 2015, Pages 995-1005

  Lee, Seungjoo ^a   Kim, Il Kug ^a   Ahn, Jae Sung ^b   Woo, Dong Cheol ^c   Kim, Sang Tae ^c   Song, Sukhyun ^a   Koh, Gou Young ^a   Kim, Hyung Seok ^d   Jeon, Byeong Hwa ^e   Kim, Injune ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Asan Medical Center   (South Korea)

^d Chonnam National University Medical School   (South Korea)

^e Chungnam National University   (South Korea)

Author keywords

Cerebrovascular disorders; Endothelial cells; Intracranial aneurysm; Transcription factors

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOPOIETIN 2; BETA ACTIN; CD31 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 4; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PROTEIN P53; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR SOX17; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN A; VASCULOTROPIN C; ANGIOTENSIN II; CYCLIN DEPENDENT KINASE INHIBITOR; HIGH MOBILITY GROUP B PROTEIN; SOX17 PROTEIN, HUMAN; SOX17 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ARTERY; CELL ADHESION; CELL REGENERATION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENE; HYPERTENSION; INTRACRANIAL ANEURYSM; MOUSE; NONHUMAN; PARACRINE SIGNALING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOX17 GENE; ADULT; AGED; ANIMAL; AORTA; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CHEMISTRY; COMPLICATION; DEFICIENCY; DISEASE MODEL; FEMALE; GENETIC TRANSCRIPTION; GENETICS; GERMFREE ANIMAL; HUMAN; KNOCKOUT MOUSE; LESIONS AND DEFECTS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; RNA INTERFERENCE; SMOOTH MUSCLE FIBER; SUBARACHNOID HEMORRHAGE; UPREGULATION; VASCULAR ENDOTHELIUM; VEIN;

ADULT; AGED; ANGIOTENSIN II; ANIMALS; AORTA; CELLS, CULTURED; CEREBRAL ARTERIES; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FEMALE; HMGB PROTEINS; HUMANS; HYPERTENSION; INTRACRANIAL ANEURYSM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; PARACRINE COMMUNICATION; RNA INTERFERENCE; SOXF TRANSCRIPTION FACTORS; SPECIFIC PATHOGEN-FREE ORGANISMS; SUBARACHNOID HEMORRHAGE; TRANSCRIPTION, GENETIC; UP-REGULATION; VEINS;

EID: 84929505845     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.012568     Document Type: Article

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