Septic shock sera containing circulating histones induce dendritic cell-regulated necrosis in fatal septic shock patients

Critical Care Medicine

Volumn 43, Issue 4, 2015, Pages e107-e116

  Raffray, Loic ^a,b   Douchet, Isabelle ^b   Augusto, Jean Francois ^c   Youssef, Jihad ^a   Contin Bordes, Cecile ^b,d   Richez, Christophe ^b,d   Duffau, Pierre ^b,d   Truchetet, Marie Elise ^b,d   Moreau, Jean Francois ^b,d   Cazanave, Charles ^d   Leroux, Lionel ^d   Mourrissoux, Gaelle ^a   Camou, Fabrice ^a,d   Clouzeau, Benjamin ^e   Jeannin, Pascale ^c   Delneste, Yves ^c   Gabinski, Claude ^a,d   Guisset, Olivier ^a,d   Lazaro, Estibaliz ^b,d   Blanco, Patrick ^a,b,d  

^a HÔPITAL SAINT ANDRÉ   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c UNIVERSITÉ D'ANGERS   (France)

^d BORDEAUX UNIVERSITY HOSPITAL   (France)

^e HÔPITAL PELLEGRIN   (France)

Author keywords

Dendritic cell; Histone; Human; Immunology; Immunosuppression; Septic shock

Indexed keywords

HISTONE; LIPOCORTIN 5; CASPASE; NUCLEOSOME;

ADULT; APOPTOSIS; ARTICLE; CARDIOGENIC SHOCK; CELL DEATH; CONTROLLED STUDY; DENDRITIC CELL; FATALITY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MONOCYTE DERIVED DENDRITIC CELL; PATHOGENESIS; PRIORITY JOURNAL; PROPIDIUM IODIDE ASSAY; PROSPECTIVE STUDY; SEPTIC SHOCK; AGED; BLOOD; MIDDLE AGED; MORTALITY; NECROSIS; NUCLEOSOME; PATHOLOGY; PHYSIOLOGY;

ADULT; AGED; CASPASES; CELL DEATH; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HISTONES; HUMANS; MALE; MIDDLE AGED; NECROSIS; NUCLEOSOMES; PROSPECTIVE STUDIES; SHOCK, CARDIOGENIC; SHOCK, SEPTIC;

EID: 84929505310     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000879     Document Type: Article

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