Maternal KIR haplotype influences live birth rate after double embryo transfer in IVF cycles in patients with recurrent miscarriages and implantation failure

Human Reproduction

Volumn 29, Issue 12, 2014, Pages 2637-2643

  Alecsandru, D ^a   Garrido, N ^b   Vicario, J L ^c   Barrio, A ^a   Aparicio, P ^a   Requena, A ^a   Garcia Velasco J A ^a  

^a UNIVERSIDAD REY JUAN CARLOS   (Spain)

^b INSTITUTO VALENCIANO DE INFERTILIDAD   (Spain)

^c Centro de Transfusion de Madrid   (Spain)

Author keywords

embryo transfer; live birth rate; Maternal KIR; miscarriage rate; paternal HLA C

Indexed keywords

HLA ANTIGEN CLASS 2; HLA C ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR;

ADULT; ARTICLE; BIRTH RATE; CHORION VILLUS; EMBRYO; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; FETUS GROWTH; HAPLOTYPE; HUMAN; HUMAN CELL; INFANCY; LIVE BIRTH; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; MOTHER; OOCYTE; OOCYTE DONATION; OVARY CYCLE; PREECLAMPSIA; PREGNANCY; PREIMPLANTATION EMBRYO; RECURRENT ABORTION; REPRODUCTION; RETROSPECTIVE STUDY; RISK ASSESSMENT; SPERM DONOR; SPONTANEOUS ABORTION; GENETICS; METABOLISM; MIDDLE AGED; NIDATION;

ABORTION, HABITUAL; ADULT; BIRTH RATE; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HAPLOTYPES; HLA-C ANTIGENS; HUMANS; MIDDLE AGED; RECEPTORS, KIR; RETROSPECTIVE STUDIES;

EID: 84929474888     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deu251     Document Type: Article

References (20)

1. Adams EJ, Parham P. Species-specific evolution of MHC class I genes in the higher primates. Immunol Rev. 2001; 183: 41-64
2. Apps R, Murphy SP, Fernando R, Gardner L, Ahad T, Moffett A. Human leucocyte antigen (HL). expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies. Immunology. 2009; 127: 26-39
3. Arck PC, Hecher K. Fetomaternal immune cross-Talk and its consequences for maternal and offspring's health. Nat Med. 2013; 19: 548-556
4. Burton GJ, Woods AW, Jauniaux E, Kingdom JC. Rheological and physiological consequencesof conversion of thematernal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta. 2009; 30: 473-482
5. Faridi RM, Agrawal S. Killer immunoglobulin-like receptors (KIRs) andHLA-C allorecognition patterns implicative of dominant activation of natural killer cells contribute to recurrent miscarriages. Hum Repro. 2011; 26: 491-497
6. Hiby SE, Walker JJ, O'shaughnessy KM, Redman CW, Carrington M, Trowsdale J, Moffett A. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med. 2004; 200: 957-965
7. Hiby SE, Regan L, Lo W, Farrell L, Carrington M, Moffett A. Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage. Hum Repro. 2008; 23: 972-976
8. Hiby SE, Ashrafian-Bonab M, Farrell L, Single RM, Balloux F, Carrington M, Moffett A, Ebrahimi Z. Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations'. Immunogenetics 2010a; 62: 65-73
9. Hiby SE, Apps R, Sharkey AM, Farrell LE, Gardner L, Mulder A, Claas FH, Walker JJ, Redman CW, Morgan L, et al. Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2. J Clin Invest 2010b; 120: 4102-4110
10. Hsu KC, Chida S, Geraghty DE, Dupont B. The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol Rev. 2002; 190: 40-52
11. King A, Burrows TD, Hiby SE, Bowen JM, Joseph S, Verma S, Lim PB, Gardner L, Le Bouteiller P, Ziegler A, et al. Surface expression of HLA-C antigen by human extravillous trophoblast. Placenta. 2000; 21: 376-387
12. Moffett-King A. Natural killer cells and pregnancy. Nat Rev Immunol. 2002; 2: 656-663
13. Parham P. NK cells and trophoblasts: partners in pregnancy. J Exp Med. 2004; 200: 951-955
14. Rajalingam R, Parham P, Abi-Rached L. Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors. J Immunol. 2004; 172: 356-369
15. Saito S, Takeda Y, Sakai M, Nakabayahi M, Hayakawa S. The incidence of pre-eclampsia among couples consisting of Japanese women and Caucasian men. J Reprod Immunol. 2006; 70: 93-98
16. Skjaerven R, Vatten LJ, Wilcox AJ, Rønning T, Irgens LM, Lie RT. Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. BMJ. 2005; 331: 877
17. Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P. Human diversity in killer cell inhibitory receptor genes. Immunity. 1997; 7: 753-763
18. Wang S, Li YP, Ding B, Zhao YR, Chen ZJ, Xu CY, Fu YB, Wang XT. Recurrent miscarriage is associated with a decline of decidual natural killer cells expressing killer cell immunoglobulin-like receptors specific for human leukocyte antigen C. J Obstet Gynaecol Res. 2014; 40: 1288-1295
19. Winter CC, Gumperz JE, Parham P, Long EO, Wagtmann N. Direct binding and functional transfer ofNKcell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. J Immunol. 1998; 161: 571-577
20. Xiong S, Sharkey AM, Kennedy PR, Gardner L, Farrell LE, Chazara O, Bauer J, Hiby SE, Colucci F, Moffett A. Maternal uterine NK cell-Activating receptor KIR2DS1 enhances placentation. J Clin Invest. 2013; 123: 4264-4272