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Volumn 46, Issue , 2015, Pages 136-142

Ingenol mebutate: From common weed to cancer cure

Author keywords

[No Author keywords available]

Indexed keywords

INGENOL MEBUTATE; 3-INGENYL ANGELATE; ANTINEOPLASTIC AGENT; DITERPENE; PLANT EXTRACT; PROTEIN KINASE INHIBITOR;

EID: 84929471290     PISSN: 14215721     EISSN: 16622944     Source Type: Book Series    
DOI: 10.1159/000366549     Document Type: Article
Times cited : (11)

References (29)
  • 1
    • 0347320540 scopus 로고    scopus 로고
    • Actinic keratosis: Epidemiology and progression to squamous cell carcinoma
    • Lebwohl M: Actinic keratosis: epidemiology and progression to squamous cell carcinoma. Br J Dermatol 2003; 149(suppl 66):31-33.
    • (2003) Br J Dermatol , vol.149 , pp. 31-33
    • Lebwohl, M.1
  • 2
    • 0033928865 scopus 로고    scopus 로고
    • Epidemiology of actinic keratoses and squamous cell carcinoma
    • Salasche SJ: Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 2000; 42:4-7.
    • (2000) J Am Acad Dermatol , vol.42 , pp. 4-7
    • Salasche, S.J.1
  • 3
    • 0033936811 scopus 로고    scopus 로고
    • The nature of solar keratosis: A critical review in historical perspective
    • Heaphy MR Jr, Ackerman AB: The nature of solar keratosis: a critical review in historical perspective. J Am Acad Dermatol 2000; 43:138-150.
    • (2000) J Am Acad Dermatol , vol.43 , pp. 138-150
    • Heaphy, M.R.1    Ackerman, A.B.2
  • 5
    • 33745010916 scopus 로고    scopus 로고
    • Solar (actinic) keratosis is squamous cell carcinoma
    • Ackerman AB, Mones JM: Solar (actinic) keratosis is squamous cell carcinoma. Br J Dermatol 2006; 155:9-22.
    • (2006) Br J Dermatol , vol.155 , pp. 9-22
    • Ackerman, A.B.1    Mones, J.M.2
  • 6
    • 0033940686 scopus 로고    scopus 로고
    • Clinical presentation of actinic keratoses and squamous cell carcinoma
    • Moy RL: Clinical presentation of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 2000; 42:8-10.
    • (2000) J Am Acad Dermatol , vol.42 , pp. 8-10
    • Moy, R.L.1
  • 8
    • 84887326929 scopus 로고    scopus 로고
    • Euphorbia peplus: 18th-century insights on a 21st-century therapy
    • Nambudiri NS, Nambudiri VE: Euphorbia peplus: 18th-century insights on a 21st-century therapy. JAMA Dermatol 2013; 149:1081.
    • (2013) JAMA Dermatol , vol.149 , pp. 1081
    • Nambudiri, N.S.1    Nambudiri, V.E.2
  • 9
    • 84857448930 scopus 로고    scopus 로고
    • Dual mechanism of action of ingenol mebu-tate gel for topical treatment of actinic keratoses: Rapid lesion necrosis followed by lesion-specific immune response
    • Rosen RH, Gupta AK, Tyring SK: Dual mechanism of action of ingenol mebu-tate gel for topical treatment of actinic keratoses: rapid lesion necrosis followed by lesion-specific immune response. J Am Acad Dermatol 2012; 66:486-493.
    • (2012) J Am Acad Dermatol , vol.66 , pp. 486-493
    • Rosen, R.H.1    Gupta, A.K.2    Tyring, S.K.3
  • 10
    • 0017163186 scopus 로고
    • Home treatment of basal cell carcinoma
    • Weedon D, Chicj J: Home treatment of basal cell carcinoma. Med J Aust 1976; 1: 928.
    • (1976) Med J Aust , vol.1 , pp. 928
    • Weedon, D.1    Chicj, J.2
  • 14
    • 12344274453 scopus 로고    scopus 로고
    • In-genol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells
    • Gillespie SK, Zhang XD, Hersey P: In-genol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells. Mol Cancer Ther 2004; 3:1651-1658.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1651-1658
    • Gillespie, S.K.1    Zhang, X.D.2    Hersey, P.3
  • 15
    • 33750536856 scopus 로고    scopus 로고
    • Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-depen-dent hyperactivation of the mitogen-activated protein kinase pathway
    • Cozzi SJ, Parsons PG, Ogbourne SM, Pedley J, Boyle GM: Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-depen-dent hyperactivation of the mitogen-activated protein kinase pathway. Cancer Res 2006; 66:10083-10091.
    • (2006) Cancer Res , vol.66 , pp. 10083-10091
    • Cozzi, S.J.1    Parsons, P.G.2    Ogbourne, S.M.3    Pedley, J.4    Boyle, G.M.5
  • 16
    • 23744432856 scopus 로고    scopus 로고
    • PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC
    • Hampson P, Chahal H, Khanim F, Hayden R, Mulder A, Assi LK, Bunce CM, Lord JM: PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood 2005; 106:1362-1368.
    • (2005) Blood , vol.106 , pp. 1362-1368
    • Hampson, P.1    Chahal, H.2    Khanim, F.3    Hayden, R.4    Mulder, A.5    Assi, L.K.6    Bunce, C.M.7    Lord, J.M.8
  • 19
    • 77954949361 scopus 로고    scopus 로고
    • Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta
    • Lee WY, Hampson P, Coulthard L, Ali F, Salmon M, Lord JM, Scheel-Toellner D: Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta. J Biol Chem 2010; 285:23889-23898.
    • (2010) J Biol Chem , vol.285 , pp. 23889-23898
    • Lee, W.Y.1    Hampson, P.2    Coulthard, L.3    Ali, F.4    Salmon, M.5    Lord, J.M.6    Scheel-Toellner, D.7
  • 20
    • 34250644927 scopus 로고    scopus 로고
    • Circulating T cells in patients with untreated acute myelogenous leukemia are heterogeneous and can be activated through the CD3/TCR complex
    • Ersvaer E, Hampson P, Wendelbo Ø, Lord JM, Gjertsen BT, Bruserud Ø: Circulating T cells in patients with untreated acute myelogenous leukemia are heterogeneous and can be activated through the CD3/TCR complex. Hematology 2007; 12:199-207.
    • (2007) Hematology , vol.12 , pp. 199-207
    • Ersvaer, E.1    Hampson, P.2    Wendelbo Ø3    Lord, J.M.4    Gjertsen, B.T.5    Bruserud Ø6
  • 21
    • 44249099692 scopus 로고    scopus 로고
    • The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-delta dependent manner
    • Hampson P, Kavanagh D, Smith E, Wang K, Lord JM, Ed Rainger G: The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-delta dependent manner. Cancer Immunol Immunother 2008; 57:1241-1251.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 1241-1251
    • Hampson, P.1    Kavanagh, D.2    Smith, E.3    Wang, K.4    Lord, J.M.5    Ed Rainger, G.6
  • 22
    • 77953155672 scopus 로고    scopus 로고
    • The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature
    • Li L, Shukla S, Lee A, Garfield SH, Malo-ney DJ, Ambudkar SV, Yuspa SH: The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res 2010; 70:4509-4519.
    • (2010) Cancer Res , vol.70 , pp. 4509-4519
    • Li, L.1    Shukla, S.2    Lee, A.3    Garfield, S.H.4    Malo-Ney, D.J.5    Ambudkar, S.V.6    Yuspa, S.H.7
  • 23
    • 58249101137 scopus 로고    scopus 로고
    • PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: Results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study
    • Siller G, Gebauer K, Welburn P, Kat-samas J, Ogbourne SM: PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study. Australas J Dermatol 2009; 50:16-22.
    • (2009) Australas J Dermatol , vol.50 , pp. 16-22
    • Siller, G.1    Gebauer, K.2    Welburn, P.3    Kat-Samas, J.4    Ogbourne, S.M.5
  • 24
    • 65749118370 scopus 로고    scopus 로고
    • Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025 and 0.05% for actinic keratosis
    • Anderson L, Schmieder GJ, Werschler WP, Tschen EH, Ling MR, Stough DB, Katsamas J: Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025 and 0.05% for actinic keratosis. J Am Acad Dermatol 2009; 60:934-943.
    • (2009) J Am Acad Dermatol , vol.60 , pp. 934-943
    • Anderson, L.1    Schmieder, G.J.2    Werschler, W.P.3    Tschen, E.H.4    Ling, M.R.5    Stough, D.B.6    Katsamas, J.7
  • 27
    • 80054019728 scopus 로고    scopus 로고
    • Factors related to pain during routine photodynamic therapy: A descriptive study of 301 patients
    • Miller IM, Nielsen JS, Lophaven S, Jem-ec GB: Factors related to pain during routine photodynamic therapy: a descriptive study of 301 patients. J Eur Acad Dermatol Venereol 2011; 25:1275-1281.
    • (2011) J Eur Acad Dermatol Venereol , vol.25 , pp. 1275-1281
    • Miller, I.M.1    Nielsen, J.S.2    Lophaven, S.3    Jem-Ec, G.B.4
  • 29
    • 84881601345 scopus 로고    scopus 로고
    • Network meta-analysis of the outcome 'participant complete clearance' in nonimmunosup-pressed participants of eight interventions for actinic keratosis: A follow-up on a Cochrane review
    • Gupta AK, Paquet M: Network meta-analysis of the outcome 'participant complete clearance' in nonimmunosup-pressed participants of eight interventions for actinic keratosis: a follow-up on a Cochrane review. Br J Dermatol 2013; 169:250-259.
    • (2013) Br J Dermatol , vol.169 , pp. 250-259
    • Gupta, A.K.1    Paquet, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.