The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-δ dependent manner

Cancer Immunology, Immunotherapy

Volumn 57, Issue 8, 2008, Pages 1241-1251

  Hampson, Peter ^a   Kavanagh, Dean ^a   Smith, Emily ^a   Wang, Keqing ^a   Lord, Janet M ^a   Ed Rainger, G ^a,b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Cytotoxic leukocytes; Endothelial cells; Inflammation; Leukocyte recruitment; Skin cancer

Indexed keywords

ANTINEOPLASTIC AGENT; BISINDOLYLMALEIMIDE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INGENOL 3 ANGELATE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; PADGEM PROTEIN; PROTEIN KINASE C DELTA; SMALL INTERFERING RNA;

ARTICLE; CELL ACTIVATION; CELL ADHESION; CYTOTOXIC LYMPHOCYTE; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPOTHESIS; IMMUNOFLUORESCENCE; INFLAMMATION; NEUTROPHIL; PRIORITY JOURNAL; SKIN CANCER;

ADULT; ANTINEOPLASTIC AGENTS; CELL ADHESION; CELLS, CULTURED; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; E-SELECTIN; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTERS; GENE EXPRESSION PROFILING; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; NEUTROPHILS; PROTEIN KINASE C-DELTA; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION;

EID: 44249099692     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-008-0458-9     Document Type: Article

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