-
2
-
-
84872611820
-
Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer
-
Provenzano PP, Hingorani SR: Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. Br J Cancer 108:1-8, 2013
-
(2013)
Br J Cancer
, vol.108
, pp. 1-8
-
-
Provenzano, P.P.1
Hingorani, S.R.2
-
4
-
-
84902435628
-
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
-
Rhim AD, Oberstein PE, Thomas DH, et al: Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25:735-747, 2014
-
(2014)
Cancer Cell
, vol.25
, pp. 735-747
-
-
Rhim, A.D.1
Oberstein, P.E.2
Thomas, D.H.3
-
5
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ, et al: Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324:1457-1461, 2009
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
-
6
-
-
84902469661
-
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
-
Özdemir BC, Pentcheva-Hoang T, Carstens JL, et al: Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25:719-734, 2014
-
(2014)
Cancer Cell
, vol.25
, pp. 719-734
-
-
Odie1
zdemir, B.C.2
Pentcheva-Hoang, T.3
Carstens, J.L.4
-
7
-
-
84929346406
-
Randomized phase II trial of gemcitabine plus TH-302 versus gemcitabine in patients with advanced pancreatic cancer
-
epub ahead of print on December 15
-
Borad MJ, Reddy SG, Bahary N, et al: Randomized phase II trial of gemcitabine plus TH-302 versus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol [epub ahead of print on December 15, 2014]
-
(2014)
J Clin Oncol
-
-
Borad, M.J.1
Reddy, S.G.2
Bahary, N.3
-
8
-
-
34447122556
-
Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104
-
Patterson AV, Ferry DM, Edmunds SJ, et al: Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin Cancer Res 13:3922-3932, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3922-3932
-
-
Patterson, A.V.1
Ferry, D.M.2
Edmunds, S.J.3
-
10
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
Bergers G, Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3:401-410, 2003
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
11
-
-
54049134838
-
Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis
-
Vaupel P: Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis. Oncologist 13:21-26, 2008
-
(2008)
Oncologist
, vol.13
, pp. 21-26
-
-
Vaupel, P.1
-
12
-
-
33749451610
-
Molecular pathways in renal cell carcinoma: Rationale for targeted treatment
-
Kim WY, Kaelin WG Jr: Molecular pathways in renal cell carcinoma: Rationale for targeted treatment. Semin Oncol 33:588-595, 2006
-
(2006)
Semin Oncol
, vol.33
, pp. 588-595
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
13
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
Kim WY, Kaelin WG: Role of VHL gene mutation in human cancer. J Clin Oncol 22:4991-5004, 2004
-
(2004)
J Clin Oncol
, vol.22
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
14
-
-
39749114978
-
Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability
-
Bristow RG, Hill RP: Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 8:180-192, 2008
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 180-192
-
-
Bristow, R.G.1
Hill, R.P.2
-
15
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
Graeber TG, Osmanian C, Jacks T, et al: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379:88-91, 1996
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
-
16
-
-
76049100577
-
HIF-1: Upstream and downstream of cancer metabolism
-
Semenza GL: HIF-1: Upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20:51-56, 2010
-
(2010)
Curr Opin Genet Dev
, vol.20
, pp. 51-56
-
-
Semenza, G.L.1
-
17
-
-
84901594345
-
Hypoxia and the extracellular matrix: Drivers of tumour metastasis
-
Gilkes DM, Semenza GL, Wirtz D: Hypoxia and the extracellular matrix: Drivers of tumour metastasis. Nat Rev Cancer 14:430-439, 2014
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 430-439
-
-
Gilkes, D.M.1
Semenza, G.L.2
Wirtz, D.3
-
18
-
-
78649658053
-
Structural studies on human 2-oxoglutarate dependent oxygenases
-
McDonough MA, Loenarz C, Chowdhury R, et al: Structural studies on human 2-oxoglutarate dependent oxygenases. Curr Opin Struct Biol 20:659-672, 2010
-
(2010)
Curr Opin Struct Biol
, vol.20
, pp. 659-672
-
-
McDonough, M.A.1
Loenarz, C.2
Chowdhury, R.3
-
19
-
-
0037423948
-
HIF-1alpha is essential for myeloid cell-mediated inflammation
-
Cramer T, Yamanishi Y, Clausen BE, et al: HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112:645-657, 2003
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
-
20
-
-
84908141221
-
HIF transcription factors, inflammation, and immunity
-
Palazon A, Goldrath AW, Nizet V, et al: HIF transcription factors, inflammation, and immunity. Immunity 41:518-528, 2014
-
(2014)
Immunity
, vol.41
, pp. 518-528
-
-
Palazon, A.1
Goldrath, A.W.2
Nizet, V.3
-
21
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
Dang EV, Barbi J, Yang HY, et al: Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146:772-784, 2011
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
-
22
-
-
79957534572
-
Targeting hypoxia in cancer therapy
-
Wilson WR, Hay MP: Targeting hypoxia in cancer therapy. Nat Rev Cancer 11:393-410, 2011
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 393-410
-
-
Wilson, W.R.1
Hay, M.P.2
-
23
-
-
0022493495
-
SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman EM, Brown JM, Lemmon MJ, et al: SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int J Radiat Oncol Biol Phys 12:1239-1242, 1986
-
(1986)
Int J Radiat Oncol Biol Phys
, vol.12
, pp. 1239-1242
-
-
Zeman, E.M.1
Brown, J.M.2
Lemmon, M.J.3
-
24
-
-
77954600498
-
Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): A phase III trial of the Trans-Tasman Radiation Oncology Group
-
Rischin D, Peters LJ, O'Sullivan B, et al: Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): A phase III trial of the Trans-Tasman Radiation Oncology Group. J Clin Oncol 28:2989-2995, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 2989-2995
-
-
Rischin, D.1
Peters, L.J.2
O'Sullivan, B.3
-
25
-
-
33644817804
-
Phase III trial of paclitaxel plus carboplatin with or without tirapazamine in advanced non-small-cell lung cancer: Southwest Oncology Group Trial S0003
-
Williamson SK, Crowley JJ, Lara PN Jr, et al: Phase III trial of paclitaxel plus carboplatin with or without tirapazamine in advanced non-small-cell lung cancer: Southwest Oncology Group Trial S0003. J Clin Oncol 23:9097-9104, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 9097-9104
-
-
Williamson, S.K.1
Crowley, J.J.2
Lara, P.N.3
-
26
-
-
33747443851
-
Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxiatargeted anticancer drugs
-
Hicks KO, Pruijn FB, Secomb TW, et al: Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxiatargeted anticancer drugs. J Natl Cancer Inst 98:1118-1128, 2006
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1118-1128
-
-
Hicks, K.O.1
Pruijn, F.B.2
Secomb, T.W.3
-
27
-
-
84929448986
-
-
Reference deleted
-
Reference deleted
-
-
-
-
28
-
-
34247527730
-
Hypoxia-inducible factors, stem cells, and cancer
-
Keith B, Simon MC: Hypoxia-inducible factors, stem cells, and cancer. Cell 129:465-472, 2007
-
(2007)
Cell
, vol.129
, pp. 465-472
-
-
Keith, B.1
Simon, M.C.2
-
29
-
-
84896341950
-
Activity of the hypoxia-activated pro-drug TH-302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy
-
Saggar JK, Tannock IF: Activity of the hypoxia-activated pro-drug TH-302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy. Int J Cancer 134:2726-2734, 2014
-
(2014)
Int J Cancer
, vol.134
, pp. 2726-2734
-
-
Saggar, J.K.1
Tannock, I.F.2
-
30
-
-
59149085477
-
The hypoxia-activated ProDrug AQ4N penetrates deeply in tumor tissues and complements the limited distribution of mitoxantrone
-
Trédan O, Garbens AB, Lalani AS, et al: The hypoxia-activated ProDrug AQ4N penetrates deeply in tumor tissues and complements the limited distribution of mitoxantrone. Cancer Res 69:940-947, 2009
-
(2009)
Cancer Res
, vol.69
, pp. 940-947
-
-
Trédan, O.1
Garbens, A.B.2
Lalani, A.S.3
-
31
-
-
29344443251
-
The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors
-
Primeau AJ, Rendon A, Hedley D, et al: The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors. Clin Cancer Res 11:8782-8788, 2005
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8782-8788
-
-
Primeau, A.J.1
Rendon, A.2
Hedley, D.3
-
32
-
-
0032781104
-
Doxorubicin gradients in human breast cancer
-
Lankelma J, Dekker H, Luque FR, et al: Doxorubicin gradients in human breast cancer. Clin Cancer Res 5:1703-1707, 1999
-
(1999)
Clin Cancer Res
, vol.5
, pp. 1703-1707
-
-
Lankelma, J.1
Dekker, H.2
Luque, F.R.3
-
33
-
-
33751543273
-
Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
-
Tatum JL, Kelloff GJ, Gillies RJ, et al: Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol 82:699-757, 2006
-
(2006)
Int J Radiat Biol
, vol.82
, pp. 699-757
-
-
Tatum, J.L.1
Kelloff, G.J.2
Gillies, R.J.3
-
34
-
-
84905103883
-
Fibroblast heterogeneity in the cancer wound
-
Öhlund D, Elyada E, Tuveson D: Fibroblast heterogeneity in the cancer wound. J Exp Med 211:1503-1523, 2014
-
(2014)
J Exp Med
, vol.211
, pp. 1503-1523
-
-
Öhlund, D.1
Elyada, E.2
Tuveson, D.3
-
35
-
-
77649186477
-
Breast and prostate cancer: More similar than different
-
Risbridger GP, Davis ID, Birrell SN, et al: Breast and prostate cancer: More similar than different. Nat Rev Cancer 10:205-212, 2010
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 205-212
-
-
Risbridger, G.P.1
Davis, I.D.2
Birrell, S.N.3
-
36
-
-
84907515188
-
Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma
-
Chawla SP, Cranmer LD, Van Tine BA, et al: Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma. J Clin Oncol 32:3299-3306, 2014
-
(2014)
J Clin Oncol
, vol.32
, pp. 3299-3306
-
-
Chawla, S.P.1
Cranmer, L.D.2
Van Tine, B.A.3
-
37
-
-
78049398107
-
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
-
Yachida S, Jones S, Bozic I, et al: Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467:1114-1117, 2010
-
(2010)
Nature
, vol.467
, pp. 1114-1117
-
-
Yachida, S.1
Jones, S.2
Bozic, I.3
-
38
-
-
84919873637
-
Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling
-
Mathew E, Zhang Y, Holtz AM, et al: Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Rep 9:484-494, 2014
-
(2014)
Cell Rep
, vol.9
, pp. 484-494
-
-
Mathew, E.1
Zhang, Y.2
Holtz, A.M.3
-
39
-
-
84904994417
-
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
-
Lee JJ, Perera RM, Wang H, et al: Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci 111:E3091-E3100, 2014
-
(2014)
Proc Natl Acad Sci
, vol.111
, pp. E3091-E3100
-
-
Lee, J.J.1
Perera, R.M.2
Wang, H.3
-
40
-
-
84907485104
-
Vitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
-
Sherman MH, Yu RT, Engle DD, et al: Vitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 159:80-93, 2014
-
(2014)
Cell
, vol.159
, pp. 80-93
-
-
Sherman, M.H.1
Yu, R.T.2
Engle, D.D.3
-
41
-
-
0345707572
-
Oxygenation gain factor: A novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers
-
Vaupel P, Mayer A, Briest S, et al: Oxygenation gain factor: A novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers. Cancer Res 63:7634-7637, 2003
-
(2003)
Cancer Res
, vol.63
, pp. 7634-7637
-
-
Vaupel, P.1
Mayer, A.2
Briest, S.3
|