Zinc oxide nanoparticles: A 90-day repeated-dose dermal toxicity study in rats

International Journal of Nanomedicine

Volumn 9, Issue , 2014, Pages 137-144

  Ryu, Hwa Jung ^a   Seo, Mu Yeb ^b   Jung, Sung Kyu ^a   Maeng, Eun Ho ^b   Lee, Seung Young ^b   Jang, Dong Hyouk ^b   Lee, Taek Jin ^b   Jo, Ki Yeon ^b   Kim, Yu Ri ^a   Cho, Kyu Bong ^c   Kim, Meyoung Kon ^a   Lee, Beom Jun ^d   Son, Sang Wook ^a  

^a Korea University College of Medicine   (South Korea)

^b Korea Testing and Research Institute   (South Korea)

^c Shinhan University   (South Korea)

^d Chungbuk National University   (South Korea)

Author keywords

Dermal exposure; Nanoparticles; Subchronic toxicity; Zinc oxide

Indexed keywords

ZINC OXIDE NANOPARTICLE; NANOPARTICLE; ZINC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APPLICATION SITE IRRITATION; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FECES LEVEL; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; LARGE INTESTINE; LIVER LEVEL; MALE; MORTALITY; NO-OBSERVED-ADVERSE-EFFECT LEVEL; NONHUMAN; RAT; SKIN PENETRATION; SKIN TOXICITY; SMALL INTESTINE; TISSUE DISTRIBUTION; TOXICITY TESTING; ANIMAL; CHEMISTRY; CUTANEOUS DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, CUTANEOUS; ANIMALS; NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS, CHRONIC; ZINC OXIDE;

EID: 84929409344     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S57930     Document Type: Article

References (17)

1. Gulson B, McCall M, Korsch M, et al. Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin. Toxicol Sci. 2010;118(1):140–149.
2. Smijs TG, Bouwstra JA. Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact. J Biomed Nanotechnol. 2010;6(5):469–484.
3. Martorano LM, Stork CJ, Li YV. UV irradiation-induced zinc disso­ciation from commercial zinc oxide sunscreen and its action in human epidermal keratinocytes. J Cosmet Dermatol. 2010;9(4):276–286.
4. Surekha P, Kishore AS, Srinivas A, et al. Repeated dose dermal toxicity study of nano zinc oxide with Sprague-Dawley rats. Cutan Ocul Toxicol. 2012;31(1):26–32.
5. 2-penetration in the epidermis of human skin xenografts. Nucl Instrum Methods Phys Res. 2005;231(1):280–285.
6. Burnett ME, Wang SQ. Current sunscreen controversies: a critical review. Photodermatol Photoimmunol Photomed. 2011;27(2):58–67.
7. Jang YS, Lee EY, Park YH, et al. The potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticles. Mol Cell Toxicol. 2012;8(2):171–177.
8. Lee SH, Pie JE, Kim YR, Lee HR, Son SW, Kim MK. Effects of zinc oxide nanoparticles on gene expression profile in human keratinocytes. Mol Cell Toxicol. 2012;8(2):113–118.
9. Pasupuleti S, Alapati S, Ganapathy S, Anumolu G, Pully NR, Prakhya BM. Toxicity of zinc oxide nanoparticles through oral route. Toxicol Ind Health. 2012;28(8):675–686.
10. Wang L, Ding W, Zhang F. Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats. J Nanosci Nanotechnol. 2010;10(12):8617–8624.
11. Pirot F, Millet J, Kalia YN, Humbert P. In vitro study of percutaneous absorption, cutaneous bioavailability and bioequivalence of zinc and copper from five topical formulations. Skin Pharmacol. 1996;9(4):259–269.
12. Cross SE, Innes B, Roberts MS, Tsuzuki T, Robertson TA, McCormick P. Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol. 2007;20(3):148–154.
13. Jeong SH, Kim JH, Yi SM, et al. Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method. Biochem Biophys Res Commun. 2010;394(3):612–615.
14. Adachi K, Yamada N, Yoshida Y, Yamamoto O. Subchronic exposure of titanium dioxide nanoparticles to hairless rat skin. Exp Dermatol. 2013;22(4):278–283.
15. Darvin ME, König K, Keller-Hoefer M, et al. Safety assessment by multiphoton fluorescence/second harmonic generation/Hyper-Rayleigh scattering tomography of ZnO nanoparticles used in cosmetic products. Skin Pharmacol Physiol. 2012;25(4):219–226.
16. Monteiro-Riviere NA, Wiench K, Landsiedel R, Schulte S, Inman AO, Riviere JE. Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study. Toxicol Sci. 2011;123(1):264–280.
17. Leita-Silva VR, Lamer ML, Sanchez WY, et al. The effect of formual­tion on the penetration of coated and uncoated zinc oxide nanoparticles into the viable epidermis of human skin in vivo. Eur J Pharm Biopharm. 2013;84(2):297–308.