Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus

Pharmacognosy Reviews

Volumn 9, Issue 17, 2015, Pages 24-28

  Zhu, Jianhua ^a   Wang, Mingxuan ^a   Wen, Wei ^a   Yu, Rongmin ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

Biosynthesis pathway; enzymes; gene expression; regulation; terpenoid indole alkaloids; vinblastine

Indexed keywords

ALKALOID; AUXIN; CATHARANTHINE; CYTOKININ; HORMONE; JASMONIC ACID; NITRIC OXIDE; PHYTOHORMONE; SALICYLIC ACID; STRICTOSIDINE; TERPENOID; TERPENOID INDOLE ALKALOID; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE; VINDOLINE;

BIOSYNTHESIS; CATHARANTHUS ROSEUS; CHEMOTHERAPY; ENZYME REGULATION; FEEDING; GENE EXPRESSION; GENE EXPRESSION REGULATION; LEUKEMIA; LIGHT; LYMPHOMA; NONHUMAN; PRECURSOR; REVIEW;

CATHARANTHUS ROSEUS;

EID: 84929406065     PISSN: 09737847     EISSN: 09762787     Source Type: Journal    
DOI: 10.4103/0973-7847.156323     Document Type: Review

References (35)

1. van Der Heijden R, Jacobs DI, Snoeijer W, Hallard D, Verpoorte R. The Catharanthus alkaloids: Pharmacognosy and biotechnology. Curr Med Chem 2004;11:607-28.
2. Costa MM, Hilliou F, Duarte P, Pereira LG, Almeida I, Leech M, et al. Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus. Plant Physiol 2008;146:403-17.
3. Rischer H, Oresic M, Seppänen-Laakso T, Katajamaa M, Lammertyn F, Ardiles-Diaz W, et al. Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells. Proc Natl Acad Sci U S A 2006;103:5614-19.
4. Liscombe DK, O'Connor SE. A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus. Phytochemistry 2011;72:1969-77.
5. El-Sayed M, Verpoorte R. Catharanthus terpenoid indole alkaloids: Biosynthesis and regulation. Phytochem Rev 2007; 6:277-305.
6. Liu D, Jin H, Chen Y, Cui L, Ren W, Gong Y, et al. Terpenoid indole alkaloids biosynthesis and metabolic engineering in Catharanthus roseus. J Integr Plant Biol 2007;49:961-74.
7. Treimer JF, Zenk MH. Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation. Eur J Biochem 1979;101:225-33.
8. Mizukami H, Nordlöv H, Lee SL, Scott AI. Purification and properties of strictosidine synthetase (an enzyme condensing tryptamine and secologanin) from Catharanthus roseus cultured cells. Biochemistry 1979;18:3760-3.
9. Geerlings A, Ibañez MM, Memelink J, van Der Heijden R, Verpoorte R. Molecular cloning and analysis of strictosidine beta-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J Biol Chem 2000;275:3051-6.
10. Rüffer M, Kan-Fan C, Husson H, Stöckigt J, Zenk MH. 4,21-Dehydrogeissoschizine, an intermediate in heteroyohimbine alkaloid biosynthesis. J Chem Soc Chem Commun 1979;22:1016-8.
11. Sottomayor M, López-Serrano M, DiCosmo F, Ros Barceló A. Purification and characterization of alpha-3′,4′-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don. FEBS Lett 1998;428:299-303.
12. Zhao J, Zhu WH, Hu Q. Effects of light and plant growth regulators on the biosynthesis of vindoline and other indole alkaloids in Catharanthus roseus callus cultures. Plant Growth Regul 2001;33:43-9.
13. Liu Y, Zhao D, Zu Y, Tang Z, Zhang Z, Jiang Y, et al. Effects of low light on terpenoid indole alkaloid accumulation and related biosynthetic pathway gene expression in leaves of Catharanthus roseus seedlings. Bot Stud 2011;52:191-6.
14. He L, Yang L, Tan R, Zhao S, Hu Z. Enhancement of vindoline production in suspension culture of the Catharanthus roseus cell line C20hi by light and methyl jasmonate elicitation. Anal Sci 2011;27:1243-8.
15. Vázquez-Flota F, Hernández-Domínguez E, de Lourdes Miranda-Ham M, Monforte-González M. A differential response to chemical elicitors in Catharanthus roseus in vitro cultures. Biotechnol Lett 2009;31:591-5.
16. Schröder G, Unterbusch E, Kaltenbach M, Schmidt J, Strack D, De Luca V, et al. Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: Tabersonine 16-hydroxylase. FEBS Lett 1999;458:97-102.
17. Ouwerkerk PB, Hallard D, Verpoorte R, Memelink J. Identification of UV-B light-responsive regions in the promoter of the tryptophan decarboxylase gene from Catharanthus roseus. Plant Mol Biol 1999;41:491-503.
18. Ramani S, Jayabaskaran C. Enhanced catharanthine and vindoline production in suspension cultures of Catharanthus roseus by ultraviolet-?B light. J Mol Signal 2008;3:9.
19. Arvy MP, Imbault N, Naudascher F, Thiersault M, Doireau P. 2,4-D and alkaloid accumulation in periwinkle cell suspensions. Biochimie 1994;76:410-6.
20. Hedhili S, Courdavault V, Giglioli-Guivarc'h N, Gantet P. Regulation of the terpene moiety biosynthesis of Catharanthus roseus terpene indole alkaloids. Phytochem Rev 2007;6:341-51.
21. Pasquali G, Goddijn OJ, de Waal A, Verpoorte R, Schilperoort RA, Hoge JH, et al. Coordinated regulation of two indole alkaloid biosynthetic genes from Catharanthus roseus by auxin and elicitors. Plant Mol Biol 1992;18:1121-31.
22. Veau B, Courtois M, Oudin A, Chénieux JC, Rideau M, Clastre M. Cloning and expression of cDNAs encoding two enzymes of the MEP pathway in Catharanthus roseus. Biochim Biophys Acta 2000;1517:159-63.
23. Papon N, Bremer J, Vansiri A, Andreu F, Rideau M, Crèche J. Cytokinin and ethylene control indole alkaloid production at the level of the MEP/terpenoid pathway in Catharanthus roseus suspension cells. Planta Med 2005;71:572-4.
24. El-Sayed M, Verpoorte R. Growth, metabolic profiling and enzymes activities of Catharanthus roseus seedlings treated with plant growth regulators. Plant Growth Regul 2004;44:53-8.
25. Pan Q, Chen Y, Wang Q, Yuan F, Xing S, Tian Y, et al. Effect of plant growth regulators on the biosynthesis of vinblastine, vindoline and catharanthine in Catharanthus roseus. Plant Growth Regul 2010;60:133-41.
26. Wen W, Zhu J, Liu J, Yu RM. Impact of artemisinic acid on the growth and catharanthine production in Catharanthus roseus cultured cells. J Med Plants Res 2012;6:2019-28.
27. Liu J, Zhu J, Tang L, Wen W, Lv S, Yu R. Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation. World J Microbiol Biotechnol 2014;30:175-80.
28. Montiel G, Zarei A, Körbes AP, Memelink J. The Jasmonate-responsive element from the ORCA3 promoter from Catharanthus roseus is active in Arabidopsis and is controlled by the transcription factor AtMYC2. Plant Cell Physiol 2011;52:578-87.
29. Rijhwani SK, Shanks JV. Effect of elicitor dosage and exposure time on biosynthesis of indole alkaloids by Catharanthus roseus hairy root cultures. Biotechnol Prog 1998;14:442-9.
30. Wei S. Methyl jasmonic acid induced expression pattern of terpenoid indole alkaloid pathway genes in Catharanthus roseus seedlings. Plant Growth Regul 2010;61:243-51.
31. Goklany S, Rizvi NF, Loring RH, Cram EJ, Lee-Parsons CW. Jasmonate-dependent alkaloid biosynthesis in Catharanthus roseus hairy root cultures is correlated with the relative expression of Orca and Zct transcription factors. Biotechnol Prog 2013;29:1367-76.
32. Idrees M, Naeem M, Aftab T, Khan MM, Moinuddin. Salicylic acid mitigates salinity stress by improving antioxidant defence system and enhances vincristine and vinblastine alkaloids production in periwinkle [Catharanthus roseus (L.) G. Don]. Acta Physiol Plant 2011;33:987-99.
33. Li M, Peebles CA, Shanks JV, San KY. Effect of sodium nitroprusside on growth and terpenoid indole alkaloid production in Catharanthus roseus hairy root cultures. Biotechnol Prog 2011;27:625-30.
34. Baldi A, Dixit VK. Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. Bioresource Technol 2008;99:4609-14.
35. Zeng Y, Yan F, Tang L, Chen F. Increased crocin production and induction frequency of stigma-like structure from floral organs of Crocus sativus by precursor feeding. Plant Cell Tiss Organ 2003;72:185-91.