A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Koneru, Mythili ^a,b   O'Cearbhaill, Roisin ^a,b   Pendharkar, Swati ^a   Spriggs, David R ^a,b   Brentjens, Renier J ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Chimeric antigen receptors; IL 12; MUC16; Ovarian cancer; Tumor microenvironment

Indexed keywords

CHIMERIC ANTIGEN RECEPTOR; CYCLOPHOSPHAMIDE; INTERLEUKIN 12; MUC 16 ECTO; TUMOR ANTIGEN; UNCLASSIFIED DRUG; CA 125 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; MUC16 PROTEIN, HUMAN;

ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ADVANCED CANCER; ARTICLE; CYTOKINE RELEASE SYNDROME; DNA MODIFICATION; DRUG MEGADOSE; OVARY CANCER; PHASE 1 CLINICAL TRIAL (TOPIC); T LYMPHOCYTE; BIOLOGICAL MODEL; CYTOTOXICITY; FEMALE; HUMAN; IMMUNOLOGY; OVARIAN NEOPLASMS; PROCEDURES; SECRETION (PROCESS); TUMOR RECURRENCE;

CA-125 ANTIGEN; CLINICAL TRIALS, PHASE I AS TOPIC; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HUMANS; IMMUNOTHERAPY, ADOPTIVE; INTERLEUKIN-12; MEMBRANE PROTEINS; MODELS, IMMUNOLOGICAL; NEOPLASM RECURRENCE, LOCAL; OVARIAN NEOPLASMS; RECEPTORS, ANTIGEN; T-LYMPHOCYTES;

EID: 84929392967     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0460-x     Document Type: Article

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