Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism

Journal of Neuroscience

Volumn 35, Issue 16, 2015, Pages 6307-6317

  Kim, Ji Young V ^a   Tillu, Dipti V ^b   Quinn, Tammie L ^c   Mejia, Galo L ^a,b   Shy, Adia ^a   Asiedu, Marina N K ^a,b   Murad, Elaine ^a   Schumann, Alan P ^c   Totsch, Stacie K ^c   Sorge, Robert E ^c   Mantyh, Patrick W ^a   Dussor, Gregory ^a,b   Price, Theodore J ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Chronic pain; Descending modulation; Dopamine; Nociceptive plasticity; Reconsolidation; Substance P

Indexed keywords

5,6 DIHYDROXYTRYPTAMINE; CARRAGEENAN; DESIPRAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 5 RECEPTOR; DOPAMINE BETA MONOOXYGENASE; INTERLEUKIN 6; NEUROKININ 1 RECEPTOR; OXIDOPAMINE; PROSTAGLANDIN E2; SAPORIN; SUBSTANCE P; SULPIRIDE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BENZAZEPINE DERIVATIVE;

AMPLITUDE MODULATION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR ASSESSMENT; CONTROLLED STUDY; CRYOPROTECTION; FACIAL EXPRESSION; HYPERSENSITIVITY; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFORMATION PROCESSING; MECHANICAL HYPERALGESIA; MOUSE; NERVE CELL PLASTICITY; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; HYPERALGESIA; MALE; METABOLISM; PHYSIOLOGY; POSTERIOR HORN CELL; SEROTONINERGIC NERVE CELL;

ANIMALS; BENZAZEPINES; CARRAGEENAN; DINOPROSTONE; DOPAMINERGIC NEURONS; HYPERALGESIA; INTERLEUKIN-6; MALE; MICE; POSTERIOR HORN CELLS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D5; RECEPTORS, NEUROKININ-1; SEROTONERGIC NEURONS; SULPIRIDE;

EID: 84929353497     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3481-14.2015     Document Type: Article

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