Reactivation of lysosomal Ca2+ efflux rescues abnormal lysosomal storage in FIG4-deficient cells

Journal of Neuroscience

Volumn 35, Issue 17, 2015, Pages 6801-6812

  Zou, Jianlong ^a,b   Hu, Bo ^b   Arpag, Sezgi ^b   Yan, Qing ^b,e   Hamilton, Audra ^b   Zeng, Yuan Shan ^a   Vanoye, Carlos G ^c   Li, Jun ^b,d  

^a SUN YAT SEN UNIVERSITY   (China)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d Veterans Administration   (United States)

^e SHENYANG NORMAL UNIVERSITY   (China)

Author keywords

Charcot Marie Tooth disease; Lysosomal storage; Membrane trafficking; ML SA1; Neurodegeneration; TRPML1

Indexed keywords

CALCIUM CHANNEL; DYNAMIN I; PHOSPHATASE; PROTEIN FIG4; TRANSIENT RECEPTOR POTENTIAL CHANNEL M1; UNCLASSIFIED DRUG; CALCIUM; FIG4 PROTEIN, MOUSE; FLAVOPROTEIN; FUSED HETEROCYCLIC RINGS; GUANOSINE TRIPHOSPHATASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; VACUOLIN-1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME DEFICIENCY; FIBROBLAST; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; LYSOSOME STORAGE DISEASE; MOUSE; NERVE DEGENERATION; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHWANN CELL; SPINAL GANGLION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; IN VITRO STUDY; LYSOSOME; MEMBRANE POTENTIAL; METABOLISM; MOTONEURON; NERVE CELL; NEWBORN; PATHOLOGY; PHYSIOLOGY; SCIATIC NERVE; SPINAL CORD; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ANIMALS; ANIMALS, NEWBORN; CALCIUM; CELLS, CULTURED; DOWN-REGULATION; FIBROBLASTS; FLAVOPROTEINS; GANGLIA, SPINAL; GTP PHOSPHOHYDROLASES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; IN VITRO TECHNIQUES; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOMES; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; NEURONS; SCHWANN CELLS; SCIATIC NERVE; SPINAL CORD;

EID: 84929347111     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4442-14.2015     Document Type: Article

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