Premature expression of Foxp3 in double-negative thymocytes

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Barra, Melanie M ^a   Richards, David M ^a   Hofer, Ann Cathrin ^a   Delacher, Michael ^a   Feuerer, Markus ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD5 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA DELTA CHAIN; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HNF1A PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CELL MATURATION; CELLULAR DISTRIBUTION; DOUBLE NEGATIVE THYMOCYTE; DOWN REGULATION; IN VIVO STUDY; INTRACELLULAR SIGNALING; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; DEFICIENCY; FLOW CYTOMETRY; GENE EXPRESSION; GENETICS; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

MUS;

ANIMALS; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; THYMOCYTES;

EID: 84929346734     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127038     Document Type: Article

References (20)

1. Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004; 22: 531-562. PMID: 15032588
2. Rothenberg EV, Taghon T. Molecular genetics of T cell development. Annu Rev Immunol. 2005; 23: 601-649. PMID: 15771582
3. Hsieh CS, Lee HM, Lio CW Selection of regulatory T cells in the thymus. Nat Rev Immunol. 2012; 12: 157-167. doi: 10.1038/nri3155 PMID: 22322317
4. Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005; 22: 329-341. PMID: 15780990
5. Liston A, Nutsch KM, Farr AG, Lund JM, Rasmussen JP, Koni PA, et al. Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proc Natl Acad Sci U S A. 2008; 105: 11903-11908. doi: 10.1073/ pnas.0801506105 PMID: 18695219
6. Lee HM, Hsieh CS. Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset. J Immunol. 2009; 183: 2261-2266. doi: 10.4049/jimmunol.0901304 PMID: 19620303
7. Schilham MW, Wilson A, Moerer P, Benaissa-Trouw BJ, Cumano A, Clevers HC. Critical involvement of Tcf-1 in expansion of thymocytes. J Immunol. 1998; 161: 3984-3991. PMID: 9780167
8. Staal FJ, Luis TC, Tiemessen MM. WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol. 2008; 8: 581-593. doi: 10.1038/nri2360 PMID: 18617885
9. Verbeek S, Izon D, Hofhuis F, Robanus-Maandag E, te Riele H, van de Wetering M, et al. An HMGbox- containing T-cell factor required for thymocyte differentiation. Nature. 1995; 374: 70-74. PMID: 7870176
10. Weber BN, Chi AW, Chavez A, Yashiro-Ohtani Y, Yang Q, Shestova O, et al. A critical role for TCF-1 in T-lineage specification and differentiation. Nature. 2011; 476: 63-68. doi: 10.1038/nature10279 PMID: 21814277
11. Ioannidis V, Beermann F, Clevers H, Held W. The beta-catenin-TCF-1 pathway ensures CD4(+)CD8 (+) thymocyte survival. Nat Immunol. 2001; 2: 691-697. PMID: 11477404
12. Steinke FC, Yu S, Zhou X, He B, Yang W, Zhou B, et al. TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells. Nat Immunol. 2014; 15: 646-656. doi: 10.1038/ni.2897 PMID: 24836425
13. Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, et al. Regulatory T cell-derived interleukin- 10 limits inflammation at environmental interfaces. Immunity. 2008; 28: 546-558. doi: 10.1016/j.immuni.2008.02.017 PMID: 18387831
14. Grubin CE, Kovats S, deRoos P, Rudensky AY. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity. 1997; 7: 197-208. PMID: 9285405
15. Azzam HS, Grinberg A, Lui K, Shen H, Shores EW, Love PE. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med. 1998; 188: 2301-2311. PMID: 9858516
16. McCaughtry TM, Baldwin TA, Wilken MS, Hogquist KA. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J Exp Med. 2008; 205: 2575-2584. doi: 10.1084/jem. 20080866 PMID: 18936237
17. Peaudecerf L, dos Santos PR, Boudil A, Ezine S, Pardigon N, Rocha B. The role of the gut as a primary lymphoid organ: CD8alphaalpha intraepithelial T lymphocytes in euthymic mice derive from very immature CD44+ thymocyte precursors. Mucosal Immunol. 2011; 4: 93-101. doi: 10.1038/mi.2010.47 PMID: 20737000
18. Peaudecerf L, Lemos S, Galgano A, Krenn G, Vasseur F, Di Santo JP, et al. Thymocytes may persist and differentiate without any input from bone marrow progenitors. J Exp Med. 2012; 209: 1401-1408. doi: 10.1084/jem.20120845 PMID: 22778388
19. Liston A, Farr AG, Chen Z, Benoist C, Mathis D, Manley NR, et al. Lack of Foxp3 function and expression in the thymic epithelium. J Exp Med. 2007; 204: 475-480. PMID: 17353370
20. Triulzi T, Tagliabue E, Balsari A, Casalini P. FOXP3 expression in tumor cells and implications for cancer progression. J Cell Physiol. 2013; 228: 30-35. doi: 10.1002/jcp.24125 PMID: 22674548