메뉴 건너뛰기




Volumn 7, Issue 3, 2015, Pages 205-218

The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells

Author keywords

Aging; Mesenchymal stem cells; miR 17; Osteogenesis; P53

Indexed keywords

MICRORNA; MIRN17 MICRORNA, MOUSE; PROTEIN P53; SMURF1 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

EID: 84929329793     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100728     Document Type: Article
Times cited : (62)

References (32)
  • 1
    • 32244444194 scopus 로고    scopus 로고
    • Can we delay aging? The biology and science of aging
    • Anton B, Vitetta L, Cortizo F, Sali A. Can we delay aging? The biology and science of aging. Ann N Y Acad Sci. 2005; 1057: 525-535.
    • (2005) Ann N Y Acad Sci , vol.1057 , pp. 525-535
    • Anton, B.1    Vitetta, L.2    Cortizo, F.3    Sali, A.4
  • 2
    • 77950645030 scopus 로고    scopus 로고
    • Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells
    • Wilson A, Shehadeh LA, Yu H, Webster KA. Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells. BMC Genomics. 2010; 11: 229.
    • (2010) BMC Genomics , vol.11 , pp. 229
    • Wilson, A.1    Shehadeh, L.A.2    Yu, H.3    Webster, K.A.4
  • 3
    • 84855219537 scopus 로고    scopus 로고
    • Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts
    • Cheng H, Qiu L, Ma J, Zhang H, Cheng M, Li W, Zhao X, Liu KY. Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts. Mol Biol Rep. 2011; 38: 5161-5168.
    • (2011) Mol Biol Rep , vol.38 , pp. 5161-5168
    • Cheng, H.1    Qiu, L.2    Ma, J.3    Zhang, H.4    Cheng, M.5    Li, W.6    Zhao, X.7    Liu, K.Y.8
  • 4
    • 84883215038 scopus 로고    scopus 로고
    • Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53
    • Despars G, Carbonneau CL, Bardeau P, Coutu DL, Beauséjour CM. Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53. PLoS One. 2013; 8: e73206.
    • (2013) PLoS One , vol.8
    • Despars, G.1    Carbonneau, C.L.2    Bardeau, P.3    Coutu, D.L.4    Beauséjour, C.M.5
  • 7
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: evidence from mice and humans
    • Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer. 2010; 10: 51-57.
    • (2010) Nat Rev Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 8
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
    • Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest. 2013; 123: 966-972.
    • (2013) J Clin Invest , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 10
    • 14844301705 scopus 로고    scopus 로고
    • Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway
    • Terai M, Uyama T, Sugiki T, Li XK, Umezawa A, Kiyono T. Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway. Mol Biol Cell. 2005; 16: 1491-1499.
    • (2005) Mol Biol Cell , vol.16 , pp. 1491-1499
    • Terai, M.1    Uyama, T.2    Sugiki, T.3    Li, X.K.4    Umezawa, A.5    Kiyono, T.6
  • 11
    • 13844257282 scopus 로고    scopus 로고
    • Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPARgamma2 transcription factor and TGF-beta/BMP signaling pathways
    • Moerman EJ, Teng K, Lipschitz DA, Lecka-Czernik B. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPARgamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell. 2004; 3: 379-389.
    • (2004) Aging Cell , vol.3 , pp. 379-389
    • Moerman, E.J.1    Teng, K.2    Lipschitz, D.A.3    Lecka-Czernik, B.4
  • 12
    • 34250846341 scopus 로고    scopus 로고
    • Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells
    • Wall ME, Bernacki SH, Loboa EG. Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells. Tissue Eng. 2007; 13: 1291-1298.
    • (2007) Tissue Eng , vol.13 , pp. 1291-1298
    • Wall, M.E.1    Bernacki, S.H.2    Loboa, E.G.3
  • 13
  • 14
    • 43049162965 scopus 로고    scopus 로고
    • Age-related intrinsic changes in human bonemarrow-derived mesenchymal stem cells and their differentiation to osteoblasts
    • Zhou S, Greenberger JS, Epperly MW, Goff JP, Adler C, Leboff MS, Glowacki J. Age-related intrinsic changes in human bonemarrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell. 2008; 7: 335-343.
    • (2008) Aging Cell , vol.7 , pp. 335-343
    • Zhou, S.1    Greenberger, J.S.2    Epperly, M.W.3    Goff, J.P.4    Adler, C.5    Leboff, M.S.6    Glowacki, J.7
  • 15
    • 51849167786 scopus 로고    scopus 로고
    • Effects of hindlimb unloading on ex vivo growth and osteogenic/adipogenic potentials of bone marrow-derived mesenchymal stem cells in rats
    • Pan Z, Yang J, Guo C, Shi D, Shen D, Zheng Q, Chen R, Xu Y, Xi Y, Wang J. Effects of hindlimb unloading on ex vivo growth and osteogenic/adipogenic potentials of bone marrow-derived mesenchymal stem cells in rats. Stem Cells Dev. 2008; 17: 795-804.
    • (2008) Stem Cells Dev , vol.17 , pp. 795-804
    • Pan, Z.1    Yang, J.2    Guo, C.3    Shi, D.4    Shen, D.5    Zheng, Q.6    Chen, R.7    Xu, Y.8    Xi, Y.9    Wang, J.10
  • 17
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: the cell's response to p53
    • Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer. 2002; 2: 594-604.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 18
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997; 88: 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 19
    • 0037067656 scopus 로고    scopus 로고
    • p53: good cop/bad cop
    • Sharpless NE, DePinho RA. p53: good cop/bad cop. Cell. 2002; 110: 9-12.
    • (2002) Cell , vol.110 , pp. 9-12
    • Sharpless, N.E.1    DePinho, R.A.2
  • 20
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116: 281-97.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 21
    • 22144461002 scopus 로고    scopus 로고
    • miRNAs, cancer, and stem cell division
    • Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell. 2005; 122: 6-7.
    • (2005) Cell , vol.122 , pp. 6-7
    • Croce, C.M.1    Calin, G.A.2
  • 22
    • 14844364472 scopus 로고    scopus 로고
    • Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis
    • Cheng AM, Byrom MW, Shelton J, Ford LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res. 2005; 33: 1290-1297.
    • (2005) Nucleic Acids Res , vol.33 , pp. 1290-1297
    • Cheng, A.M.1    Byrom, M.W.2    Shelton, J.3    Ford, L.P.4
  • 23
    • 77149136767 scopus 로고    scopus 로고
    • MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation
    • Huang J, Zhao L, Xing L, Chen D. MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells. 2010; 28: 357-364.
    • (2010) Stem Cells , vol.28 , pp. 357-364
    • Huang, J.1    Zhao, L.2    Xing, L.3    Chen, D.4
  • 25
    • 80054898958 scopus 로고    scopus 로고
    • MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis
    • Liu Y, Liu W, Hu C, Xue Z, Wang G, Ding B, Luo H, Tang L, Kong X, Chen X, Liu N, Ding Y, Jin Y. MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis. Stem Cells. 2011; 29: 1804-1816.
    • (2011) Stem Cells , vol.29 , pp. 1804-1816
    • Liu, Y.1    Liu, W.2    Hu, C.3    Xue, Z.4    Wang, G.5    Ding, B.6    Luo, H.7    Tang, L.8    Kong, X.9    Chen, X.10    Liu, N.11    Ding, Y.12    Jin, Y.13
  • 26
    • 84875879658 scopus 로고    scopus 로고
    • TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments
    • Liu W, Liu Y, Guo T, Hu C, Luo H, Zhang L, Shi S, Cai T, Ding Y, Jin Y. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. Cell Death Dis. 2013; 4: e539.
    • (2013) Cell Death Dis , vol.4
    • Liu, W.1    Liu, Y.2    Guo, T.3    Hu, C.4    Luo, H.5    Zhang, L.6    Shi, S.7    Cai, T.8    Ding, Y.9    Jin, Y.10
  • 28
    • 2342450524 scopus 로고    scopus 로고
    • Molecular evolution of a microRNA cluster
    • Tanzer A, Stadler PF. Molecular evolution of a microRNA cluster. J Mol Biol. 2004; 339: 327-335.
    • (2004) J Mol Biol , vol.339 , pp. 327-335
    • Tanzer, A.1    Stadler, P.F.2
  • 29
    • 27944480412 scopus 로고    scopus 로고
    • Pathophysiology of age-related bone loss and osteoporosis
    • Khosla S, Riggs BL. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am. 2005; 34: 1015-1030.
    • (2005) Endocrinol Metab Clin North Am , vol.34 , pp. 1015-1030
    • Khosla, S.1    Riggs, B.L.2
  • 30
    • 31044432767 scopus 로고    scopus 로고
    • Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    • Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest. 2005; 115: 3318-25.
    • (2005) J Clin Invest , vol.115 , pp. 3318-3325
    • Raisz, L.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.