Prenatal antidepressant exposure and the risk of autism spectrum disorders in children. Are we looking at the fall of Gods?

Journal of Affective Disorders

Volumn 182, Issue , 2015, Pages 132-137

  Gentile, Salvatore ^a,b  

^a Department of Mental Health ASL Salerno Mental Health Center   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Antidepressants; Autism spectrum disorders; Neurodevelopment; Pregnancy; Safety; SSRIs

Indexed keywords

SEROTONIN UPTAKE INHIBITOR; ANTIDEPRESSANT AGENT;

AUTISM; CHILDHOOD DISEASE; DEPRESSION; HUMAN; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; ADOLESCENT; AUTISM SPECTRUM DISORDER; CASE CONTROL STUDY; CHILD; DEPRESSIVE DISORDER; FEMALE; INFANT; MALE; METHODOLOGY; NEWBORN; PRESCHOOL CHILD; RISK;

ADOLESCENT; ANTIDEPRESSIVE AGENTS; AUTISM SPECTRUM DISORDER; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DEPRESSIVE DISORDER; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RESEARCH DESIGN; RISK; SEROTONIN UPTAKE INHIBITORS;

EID: 84929322302     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2015.04.048     Document Type: Review

References (49)

1. M. Abney, M.S. McPeek, and C. Ober Broad and narrow heritabilities of quantitative traits in a founder population Am. J. Hum. Genet. 76 2001 33 41
2. B.S. Abrahams, and D.H. Geschwind Advance in autism genetics: in the threshold of a new neurobiology Nat. Rev. Genet. 9 2008 341 355
3. S.E. Andrade, M.A. Raebel, J. Brown, et al. Use of antidepressant medications during pregnancy: a multisite study Am. J. Obstet. Gynecol. 198 2008 e1 e5
4. R.A. Carper, P. Moses, D. Tigue, and E. Courchense Cerebral lobes in autism: early hyperplasia and abnormal age effects Neuroimage 16 2013 1038 1051
5. S Chakrabarti, and E. Fombonne Pervasive developmental disorders in preschool children JAMA 285 2001 3093 3099
6. C.C. Clements, V.M. Castro, S.R. Blumenthal, et al. Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system Mol. Psychiatry 2014 Epub ahead of print
7. L.A. Croen, J.K. Grether, C.K. Yoshida, et al. Antidepressant use during pregnancy and childhood autism spectrum disorders Arch. Gen. Psychiatry 68 2011 E1 E9
8. H. El Marroun, T.J.H. White, J.F. van der Knaap, et al. Prenatal exposure to serotonin reuptake inhibitors and social responsiveness symptoms of autism: population-based study of young children Br. J. Psychiatry 205 2014 95 102
9. E. Fombonne, C. Du Mazaubrun, C. Cans, and H. Grandjean Autism and associated medical disorders in a French epidemiological survey J. Am. Acad. Child Adolesc. Psychiatry 36 1997 1561 1569
10. A. Frustaci, M. Neri, A. Cesario, et al. Oxidative stress-related biomarkers in autism: a systematic review and meta-analysis Free Radic. Biol. Med. 52 2012 2128 2141
11. A.M. Gardier, I. Malagié, A.C. Trillat, et al. Role of 5-HT1A autoreceptors in the mechanism of action of serotoninergic antidepressant drugs: recent findings from in vivo microdialysis studies Fundam. Clin. Pharmacol. 10 1996 16 27
12. H. Gardener, D. Spiegelman, and S.L. Buka Prenatal risk factors for autism: comprehensive meta-analysis Br. J. Psychiatry 195 2009 7 14
13. S. Gentile Tricyclic antidepressants in pregnancy and puerperium Exp. Opin. Drug. Saf. 13 2014 207 225
14. S. Gentile Drug treatment for mood disorders in pregnancy Curr. Opin. Psychiatry 24 2011 34 40
15. S. Gentile Suicidal mothers J. Inj. Viol. Res. 3 2011 92 97
16. S. Gentile On categorizing gestational birth, and neonatal complications following late in utero exposure to antidepressants. The prenatal antidepressant exposure syndrome CNS Spectr. 15 2010 167 185
17. S. Gentile The safety of newer antidepressants in pregnancy and breastfeeding Drug Saf. 28 2005 137 152
18. N.B. Gidaya, B.K. Lee, I. Burstyn, et al. In utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder J. Autism Dev. Disord. 44 2014 2558 2567
19. Gothic, 2014. Fall Of Gods - Live at Barock Fest. 〈https://www.youtube.com/watch?v=Kwm4k-GLd2c⌠(accessed 27.07.14).
20. K.M. Gray, C.M. Keating, J.R. Taffe, et al. Adult outcomes in Autism: Community inclusion and living skills J. Autism Dev. Disord. 44 2014 3006 3015
21. G.E. Hanley, and B. Mintzes Patterns of psychotropic medicine use in pregnancy in the United States from 2006 to 2011 among women with private insurance BMC Pregnancy Childbirth 14 2014 242
22. S.N. Hansen, E. Diana, D.E. Schendel, et al. Explaining the increase in the prevalence of Autism spectrum disorders. The proportion attributable to changes in reporting practices JAMA Pediatr. 169 2015 56 62
23. R.A. Harrington, L.C. Lee, R.M. Crum, et al. Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay Pediatrics 133 2014 e1241 e1248
24. R.A. Harrington, L.C. Lee, R.M. Crum, et al. Serotonin hypothesis of autism: implications or selective serotonin reuptake inhibitor use during pregnancy Autism Res. 6 2013 149 168
25. A. Hviid, M. Melbye, and B. Pasternak Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism N. Engl. J. Med. 369 2013 2406 2415
26. L. Kanner The original description of autism, with excellent case examples Nerv. Child 2 1943 217 250
27. M.C. Lai, M.V. Lombardo, and S. Baron-Cohen Autism Lancet 383 2014 896 910
28. K.K. Man, H.H. Tong, L.Y. Wong, et al. Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorders in children: a systematic review and meta-analysis of observational studies Neurosci. Biobehav. Rev. 49 2014 82 89
29. R.D. Maimburg, and M. Vaeth Perinatal risk factors and infantile autism Acta. Psychiatr. Scand. 114 2006 257 264
30. M.R. Meunier, I.M. Bennett, and A.S. Coco Use of antidepressant medication in the United States during pregnancy, 2002 - 2010 Psychiatr. Serv. 64 2013 1157 1160
31. J. Moss, and P. Howlin Autism spectrum disorders in genetic syndromes: implications for diagnosis, intervention and understanding the wider autism spectrum disorder population J. Intellect. Disabil. Res. 53 2009 852 873
32. T.F. Oberlander, J.A. Gingrich, and M.S. Ansorge Sustained neurobehavioral effects of exposure to SSRI antidepressant during development: molecular to clinical evidence Clin. Pharmacol. Ther. 10 2009 1 6
33. S.J.M.C. Palmen, H.E.H. Pol, C. Kemmer, et al. Increased grey-matter volume in medication-naive high functioning children with autism spectrum disorder Psychol. Med. 35 2005 561 570
34. C. Qiu, M.A. Williams, R. Calderon-Margalit, et al. Preeclampsia risk in relation to maternal mood and anxiety disorders diagnosed before or during early pregnancy Am. J. Hypertens. 22 2009 397 402
35. S. Rangasamy, S.R. D'Mello, and V. Narayanan Epigenetics, autism spectrum, and neurodevelopmental disorders Neurotherapeutics 4 2013 742 756
36. D. Rai, B.K. Lee, C. Dalman, J. Golding, et al. Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study Br. Med. J. 346 2013 f2059
37. D.A. Rossignol, and R.E. Frye Mitochondrial dysfunctions in autism spectrum disorder: a systematic review and meta-analysis Mol. Psychiatry 17 2012 290 301
38. S.J. Sanders, A.G. Ercan-Sencicek, V. Hus, R. Luo, M.T. Murtha, D. Moreno-De-Luca, et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism Neuron 70 2011 863 885
39. G.K. Singh, M.K. Kenney, R.M. Ghandour, et al. Mental health outcomes in US children and adolescents born prematurely or with low birthweight Depress. Res. Treat. 5 2013 570 574
40. M.J. Sørensen, T.K. Grønborg, J. Christensen, et al. Antidepressant exposure in pregnancy and risk of autism spectrum disorders Clin. Epidemiol. 5 2013 449 459
41. K.A. Stigler, B.C. McDonald, A Anand, et al. Structural and functional MRI studies of autism spectrum disorder Brain Res. 1380 2011 146 161
42. A. Trontell Expecting the unexpected - drug safety, pharmacovigilance, and the prepared mind N. Engl. J. Med. 351 2004 1385 1387
43. Q. Uddin, V. Menon, C.B. Young, et al. Multivariate searchlight classifications of structural magnetic resonance in children and adolescents with autisms Biol. Psychiatry 70 2011 833 841
44. I. Voineagu, and H.J. Yoo Current progress and challenges in the search for autism biomarkers Dis. Markers 35 2013 55 65
45. H. Wei, I. Alberts, and X. Li Brain IL-6 and autism Neuroscience 12 2013 320 325
46. L.A. Weiss, M. Abney, E.H. Cook, et al. Sex-specific genetic architecture of whole blood serotonin levels Am. J. Hum. Genet. 76 2005 33 41
47. P.M. Whitaker-Azmitia Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism? Int. J. Dev. Neurosci. 23 2005 75 83
48. D.S. Wilkerson, A.G. Volpe, R.S. Dean, et al. Perinatal complications as predictors of infantile autism Int. J. Neurosci. 112 2002 1085 1098
49. J.S. Woods, S.E. Armel, D.I. Futon, et al. Urinary porphyrin excretion in neurotypical and autistic children Environ. Health Perspect. 10 2010 1450 1457