Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies

Neuroscience and Biobehavioral Reviews

Volumn 49, Issue , 2015, Pages 82-89

  Man, Kenneth K C ^a   Tong, Henry H Y ^a,b   Wong, Lisa Y L ^a   Chan, Esther W ^a   Simonoff, Emily ^c   Wong, Ian C K ^a,d  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b MACAO POLYTECHNIC INSTITUTE   (Macao)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Autism spectrum disorder; Pregnancy; Serotonin reuptake inhibitor; SSRI

Indexed keywords

SEROTONIN UPTAKE INHIBITOR;

AUTISM; DISEASE ASSOCIATION; DRUG USE; HUMAN; INCIDENCE; POPULATION RESEARCH; PREGNANCY; PRENATAL DRUG EXPOSURE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SURVIVAL RATE; SYSTEMATIC REVIEW; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; FEMALE; META ANALYSIS; OBSERVATIONAL STUDY; PRENATAL EXPOSURE; RISK;

CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; FEMALE; HUMANS; OBSERVATIONAL STUDY AS TOPIC; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RISK; SEROTONIN UPTAKE INHIBITORS;

EID: 84920903484     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2014.11.020     Document Type: Review

References (26)

1. Ansorge M.S., Zhou M.M., Lira A., Hen R., Gingrich J.A. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 2004, 306(5697):879-881. 10.1126/science.1101678.
2. Baird G., Simonoff E., Pickles A., Chandler S., Loucas T., Meldrum D., et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 2006, 368(9531):210-215.
3. Baron-Cohen S., Scott F.J., Allison C., Williams J., Bolton P., Matthews F.E., et al. Prevalence of autism-spectrum conditions: UK school-based population study. Br. J. Psychiatry 2009, 194(6):500-509.
4. Bolton P.F., Pickles A., Murphy M., Rutter M. Autism, affective and other psychiatric disorders: patterns of familial aggregation. Psychol. Med. 1998, 28(2):385-395.
5. Bradley E., Bolton P. Episodic psychiatric disorders in teenagers with learning disabilities with and without autism. Br. J. Psychiatry 2006, 189(4):361-366.
6. Buescher A.V., Cidav Z., Knapp M., Mandell D.S. Costs of autism spectrum disorders in the United Kingdom and the United States. JAMA Pediatr. 2014, 10.1001/jamapediatrics.2014.210.
7. Croen L.A., Grether J.K., Yoshida C.K., Odouli R., Hendrick V. Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch. Gen. Psychiatry 2011, 68(11):1104-1112. 10.1001/archgenpsychiatry.2011.73.
8. DerSimonian R., Laird N. Meta-analysis in clinical trials. Control. Clin. Trials 1986, 7(3):177-188.
9. Eriksson M.A., Westerlund J., Anderlid B.M., Gillberg C., Fernell E. First-degree relatives of young children with autism spectrum disorders: some gender aspects. Res. Dev. Disabil. 2012, 33(5):1642-1648. 10.1016/j.ridd.2012.03.025.
10. Gidaya N.B., Lee B.K., Burstyn I., Heavner K., Michael Y.L., Yudell M., et al. In utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder. J. Autism Dev. Disord. 2014, 10.1007/s10803-014-2128-4.
11. Green H., McGinnity A., Meltzer H., Ford T., Goodman R. Mental Health of Children and Young People in Great Britain, 2004 2005, Palgrave Macmillan, New York.
12. Grigoriadis S., Vonderporten E.H., Mamisashvili L., Tomlinson G., Dennis C.L., Koren G., et al. Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis. BMJ 2014, 348:f6932. 10.1136/bmj.f6932.
13. Harrington R.A., Lee L.C., Crum R.M., Zimmerman A.W., Hertz-Picciotto I. Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay. Pediatrics 2014, 10.1542/peds.2013-3406.
14. Higgins J.P.T., Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 2011, www.cochrane-handbook.org [Accessed 04.08.14].
15. Huang H., Coleman S., Bridge J.A., Yonkers K., Katon W. A meta-analysis of the relationship between antidepressant use in pregnancy and the risk of preterm birth and low birth weight. Gen. Hosp. Psychiatry 2014, 36(1):13-18. 10.1016/j.genhosppsych.2013.08.002.
16. Hviid A., Melbye M., Pasternak B. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N. Engl. J. Med. 2013, 369(25):2406-2415. 10.1056/NEJMoa1301449.
17. Joint Formulary Committee British National Formulary (BNF) 2014, BMJ Group and Pharmaceutical Press, London. 67th ed.
18. Kendall-Tackett K., Hale T.W. The use of antidepressants in pregnant and breastfeeding women: a review of recent studies. J. Hum. Lactat. 2010, 26(2):187-195. 10.1177/0890334409342071.
19. Myles N., Newall H., Ward H., Large M. Systematic meta-analysis of individual selective serotonin reuptake inhibitor medications and congenital malformations. Aust. N. Z. J. Psychiatry 2013, 47(11):1002-1012. 10.1177/0004867413492219.
20. National Institute for Health and Clinical Excellence Antenatal and Postnatal Mental Health: Clinical Management and Service Guidance 2007, http://www.nice.org.uk/guidance/CG45/chapter/1-Guidance#principles-of-care-for-all-women-with-mental-disorders-during-pregnancy-and-the-postnatal-period [Accessed 28.07.14].
21. Rai D., Lee B.K., Dalman C., Golding J., Lewis G., Magnusson C. Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ 2013, 346:f2059. 10.1136/bmj.f2059.
22. Rampono J., Simmer K., Ilett K.F., Hackett L.P., Doherty D.A., Elliot R., et al. Placental transfer of SSRI and SNRI antidepressants and effects on the neonate. Pharmacopsychiatry 2009, 42(3):95-100. 10.1055/s-0028-1103296.
23. Simonoff E., Pickles A., Charman T., Chandler S., Loucas T., Baird G. Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J. Am. Acad. Child Adolesc. Psychiatry 2008, 47(8):921-929. 10.1097/CHI.0b013e318179964f.
24. Sontag-Padilla L., Schultz D., Reynolds K.A., Lovejoy S.L., Firth R. Maternal Depression: Implications for Systems Serving Mother and Child. Resource Document 2013, The RAND Corporation.
25. Sorensen M.J., Gronborg T.K., Christensen J., Thorlund E., Vestergaard M., Schendel D., et al. Antidepressant exposure in pregnancy and risk of autism spectrum disorders. Clin. Epidemiol. 2013, 5(1):449-459.
26. Wells G., Shea B., O'connell D., Peterson J., Welch V., Losos M., et al. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Resource document 2000, Ottawa Hospital Research Institute.