Anti-inflammatory effects of trilinolein from panax notoginseng through the suppression of NF-κB and MAPK expression and proinflammatory cytokine expression

American Journal of Chinese Medicine

Volumn 42, Issue 6, 2014, Pages 1485-1506

  Huang, Shyh Shyun ^a   Deng, Jeng Shyan ^b   Lin, Jaung Geng ^a   Lee, Chao Ying ^a   Huang, Guan Jhong ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

Author keywords

Anti Inflammation; Chinese Medicine; MDA; NO; TNF ; Trilinolein

Indexed keywords

ANTIINFLAMMATORY AGENT; CARRAGEENAN; CYCLOOXYGENASE 2; CYTOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; TRILINOLEIN; TUMOR NECROSIS FACTOR ALPHA; ANTI-INFLAMMATORY AGENTS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALONDIALDEHYDE; NITRIC OXIDE SYNTHASE TYPE II; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG INHIBITION; EXPERIMENTAL PAW EDEMA; GENE REPRESSION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PANAX NOTOGINSENG; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; WESTERN BLOTTING; ANIMALS; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; IMMUNOLOGY; ISOLATION AND PURIFICATION; MACROPHAGES; METABOLISM; MICE, INBRED ICR; PHYTOTHERAPY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL LINE; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MALONDIALDEHYDE; MICE, INBRED ICR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PANAX NOTOGINSENG; PHYTOTHERAPY; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84929321201     PISSN: 0192415X     EISSN: 17936853     Source Type: Journal    
DOI: 10.1142/S0192415X14500931     Document Type: Article

References (28)

1. Busnardo, T.C., C. Padoani, T.C. Mora, M.W. Biavatti, T.S. Fröde, C. Bürger, V.D. Claudino, E.M. Dalmarco and M. M. De Souza. Anti-inflammatory evaluation of Coronopus didymus in the pleurisy and paw oedema models in mice. J. Ethnopharmacol. 128: 519-525, 2010.
2. Chan, P., C.S. Niu, J.T. Cheng, C.W. Tsao, S.K. Tsai and C.Y. Hong. Trilinolein preserves mitochondria ultrastructure in isolated rat heart subjected to global ischemia through antioxidant activity as measured by chemiluminescence. Pharmacology 52: 216-225, 1996.
3. Chan, P., C.Y. Hong, B. Tomlinson, N.C. Chang, J.P. Chen, S.T. Lee and J.T. Cheng. Myocardial protective effect of trilinolein: An antioxidant isolated from the medicinal plant Panax pseudoginseng. Life Sci. 61: 1999-2006, 1997.
4. Chan, P. and B. Tomlinson. Antioxidant effects of Chinese traditional medicine: Focus on trilinolein isolated from the Chinese herb sanchi (Panax pseudoginseng). J. Clin. Pharmacol. 40: 457-461, 2000.
5. Chan, P.S., K. Tsai, B.N. Chiang and C.Y. Hong. Trilinolein reduces infarct size and suppresses ventricular arrhythmias in rats subjected to coronary ligation. Pharmacology 51: 118-126, 1995.
6. Chang, H.Y., M.J. Sheu, C.H. Yang, T.C. Lu, Y.S. Chang, W.H. Peng, S.S. Huang and G.J. Huang. Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice. Evid. Based Complement. Alternat. Med. 2011a: 478246, 2011a. Doi: 10.1093/ecam/nep027.
7. Chang, T.N., Y.L. Ho , G.J. Huang, S.S. Huang, H.Y. Chang, Y.C. Chiang, P.C. Hsieh and Y.S. Chang. Hepatoprotective effect of Crossostephium chinensis (L.) Makino in rats. Am. J. Chin. Med. 39: 503-521, 2011b.
8. Chen, Y.J., S.A. Chen, C.T. Tai, C.E. Chiang, M.S. Chang and C.Y. Hong. Effect of trilinolein on strophanthidin-induced ventricular tachycardia in guinea pigs. Pharmacology 58: 15-23, 1999.
9. Chiu, C.S., J.S. Deng, H.Y. Chang, Y.C. Chen, M.M. Lee, W.C. Hou, C.Y. Lee, S.S. Huang and G.J. Huang. Antioxidant and anti-inflammatory properties of Taiwanese Yam (Dioscorea japonica Thunb. var. pseudojapon ica (Hayata) Yamam.) and its reference compounds. Food Chem. 141: 1087-1109, 2013.
10. Chiu, W.T., P. Chan, S.S. Liao, J.R. Liou and J.T. Cheng. Effect of trilinolein on the activity and gene expression of superoxide dismutase in cultured rat brain astrocytes. Neuroscience Letters 269: 17-20, 1999.
11. Cuzzocrea, S., B. Zingarelli , G. Calapai, F. Nava and A.P. Caputi. Zymosan-activated plasma induces paw oedema by nitric oxide and prostaglandin production. Life Sci. 60: 215-220, 1997.
12. Garcia, F.P., E. Marin, S. Canigueral and T. Adzet. Anti-inflammatory action of Pluchea sagitalis: Involvement of an antioxidant mechanism. Life Sci. 59: 2033-2040, 1996.
13. Hong, C.Y., S.S. Huang, R. Wang, Y.J. Sung and C.F. Kwok. Trilinolein inhibits the adhesion of neutrophils to endothelial cells. Clin. Exp. Pharmacol. Physiol. 25: 99-103, 1998.
14. Huang G.J. J.S. Deng J.C. Liao W.C. Hou S.Y. Wang P.J. Sung Y.H. Kuo Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis. J. Agri. Food Chem. 60 1673-1681, 2012b.
15. Hu ang, G.J., J.S. Deng, S.S. Huang, S.Y. Wang, Y.S. Chang and Y.H. Kuo. Bioassay guided isolation and identification of anti-inflammatory active compounds from the root of Ficus formosana. J. Agric. Food Chem. 61: 11008-11015, 2013.
16. Huang, G.J., S.S. Huang and J.S. Deng. Anti-inflammatory activities of from Phellinus linteus through the inhibition of MMP-9, NF-B, and MAPK activation in vitro and in vivo. PLoS One 7: E35922, 2012a.
17. Huang, G.J., S.S. Huang, S.S. Lin, I.C. Hsieh, W.C. Hou and Y.H. Kuo. Anti-inflammatory activities of 6beta-acetoxy-7alpha-hydroxyroyleanone from Taiwania cryptomerioides Hayata ex vivo and in vivo. J. Agri. Food Chem. 59: 11211-11218, 2011.
18. Huang, G.J., S.S. Huang, S.S. Lin, Y.Y. Shao, C.C. Chen, W.C. Hou and Y.H. Kuo. Analgesic effects and the mechanism s of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice. J. Agri. Food Chem. 58: 7445-7452, 2010.
19. Liao, J.C., S.S. Huang, J.S. Deng, C.Y. Lee, Y.C. Lin and G.J. Huang. Chemical characterization and in vivo anti-Inflammatory activities of Actinidia callosa var. ephippioides via suppression of proinflammatory cytokines. Am. J. Chin. Med. 41: 405-423, 2013a.
20. Liao, J.C., J.S. Deng, C.S. Chiu, S.S. Huang, W.C. Hou, W.C. Lin and G.J. Huang. Chemical compositions, anti-inflammatory, antiproliferative and radical-scavenging activities of the methanol extracts of Actinidia callosa var. ephippioides. Am. J. Chin. Med. 41: 405-423, 2013b.
21. Lin, C.C., Y.F. Hsu and T.C. Lin. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am. J. Chin. Med. 27: 371-376, 1999.
22. Oh, Y.C., W.K. Cho, Y.H. Jeong, G.Y. Im, M.C. Yang and J.Y. Ma. Fermentation improves antiinflammatory effect of sipjeondaebotang on LPS-stimulated RAW 264.7 cells. Am. J. Chin. Med. 40: 813-831, 2012.
23. Santander, S.P., J.F. H ernandez, C.C. Barreto, A. Masayuki, H. Moins-Teisserenc and S. Fiorentino. Immunomodulatory effects of aqueous and organic fractions from Petiveria alliacea on human dendritic cells. Am. J. Chin. Med. 40: 833-844, 2012.
24. Sheu, M.J., J.S. Deng, M.H. Huang, C.H. Wu, S.S. Huang and G.J. Huang. Antioxidant and antiinflammatory properties of Dichondra repens Forst. and its reference compounds. Food Chem. 132: 1010-1018, 2012.
25. Tohda, C., N. Nakayama, F. Hatanaka and K. Komatsu. Comparison of anti-inflammatory activities of six Curcuma rhizomes: A possible curcuminoid-independent pathway mediated by Curcuma phaeocaulis extract. Evid. Based Complement. Alternat. Med. 3: 255-260, 2006.
26. Xu, Z., X. Chen, S. Fu, J. Bao, Y. Dang, M. Huang, L. Chen and Y. Wang. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am. J. Chin. Med. 40: 177-185, 2012.
27. Yayeh, T., M. Hong, Q. Jia, Y.C. Lee, H.J. Kim, E. Hyun, T.W. Kim and M.H. Rhee. Pistacia chinensis inhibits NO production and upregulates HO-1 induction via PI-3K/Akt path way in LPS stimulated macrophage cells. Am. J. Chin. Med. 40: 1085-1097, 2012.
28. Zimmermann, M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110, 1983.