Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: A pilot study

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Turowski, Jason B ^a   Pietrofesa, Ralph A ^a   Lawson, John A ^b   Christofidou Solomidou, Melpo ^b   Hadjiliadis, Denis ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antioxidant; Biomarker; Cystic fibrosis; Cytokine; Enterodiol; Enterolactone; Flaxseed; Inflammation; Lignan; Secoisolariciresinol diglucoside

Indexed keywords

AZITHROMYCIN; BIOLOGICAL MARKER; DRUG METABOLITE; ENTERODIOL; ENTEROLACTONE; ENTEROLIGNAN; ERYTHROMYCIN; HEME OXYGENASE 1; HERBACEOUS AGENT; INTERLEUKIN 1BETA; LIGNAN; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; OMEGA 3 FATTY ACID; PHENOL DERIVATIVE; PLANT EXTRACT;

ABDOMINAL DISCOMFORT; ADULT; ANAPHYLAXIS; ANTIBIOTIC THERAPY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLEEDING; BLOATING; CHEEK MUCOSA; CHRONIC DRUG ADMINISTRATION; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTIC FIBROSIS; DEFECATION HABIT; DIARRHEA; DRUG BLOOD LEVEL; DRUG ERUPTION; DRUG FATALITY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FORCED EXPIRATORY VOLUME; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LINSEED; LONG TERM CARE; LUNG INJURY; MALE; MEDICATION COMPLIANCE; ORAL BIOPSY; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PILOT STUDY; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; URINALYSIS; ADOLESCENT; ANIMAL; CHEMISTRY; DIET SUPPLEMENTATION; DRUG EFFECTS; FLAX; INFLAMMATION; LUNG; LUNG DISEASE; METABOLISM; MIDDLE AGED; MOUSE; PATHOLOGY; PHYTOTHERAPY; PLANT SEED;

ADOLESCENT; ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BIOMARKERS; CYSTIC FIBROSIS; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FEMALE; FLAX; HEME OXYGENASE-1; HUMANS; INFLAMMATION; LIGNANS; LUNG; LUNG DISEASES; MALE; MICE; MIDDLE AGED; OXIDATIVE STRESS; PHENOLS; PHYTOTHERAPY; PILOT PROJECTS; PLANT EXTRACTS; SEEDS;

EID: 84929320153     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0651-2     Document Type: Article

References (36)

1. Jaffe A, Bush A. Cystic fibrosis: review of the decade. Monaldi Arch Chest Dis. 2001;56(3):240-7.
2. Abbott J, Hart A. Measuring and reporting quality of life outcomes in clinical trials in cystic fibrosis: a critical review. Health Qual Life Outcomes. 2005;3:19.
3. Boyle MP. Cystic fibrosis: year in review. Curr Opin Pulm Med. 2010;16(6):583.
4. Amin R, Lam M, Dupuis A, Ratjen F. The effect of early Pseudomonas aeruginosa treatment on lung function in pediatric cystic fibrosis. Pediatr Pulmonol. 2011;46(6):554-8.
5. Goss CH, Muhlebach MS. Review: Staphylococcus aureus and MRSA in cystic fibrosis. J Cyst Fibros. 2011;10(5):298-306.
6. Dominguez C, Gartner S, Linan S, Cobos N, Moreno A. Enhanced oxidative damage in cystic fibrosis patients. Biofactors. 1998;8(1-2):149-53.
7. Brown RK, Wyatt H, Price JF, Kelly FJ. Pulmonary dysfunction in cystic fibrosis is associated with oxidative stress. Eur Respir J. 1996;9(2):334-9.
8. Lipson DAH D, Imbesi G, Ferrin M, Sims M, Miller S, Tal-Singer R, et al. Evidence of Elevated CXCR2 Agonists in Stable Outpatients with Cystic Fibrosis Compared with Healthy Controls. J Pulmonary Respirat Med. 2013;3(3):149.
9. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev. 2004;62(1):18-27.
10. Kinniry P, Amrani Y, Vachani A, Solomides CC, Arguiri E, Workman A, et al. Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice. J Nutr. 2006;136(6):1545-51.
11. Christofidou-Solomidou M, Tyagi S, Pietrofesa R, Dukes F, Arguiri E, Turowski J, et al. Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG). Radiat Res. 2012;178(6):568-80.
12. Christofidou-Solomidou M, Tyagi S, Tan KS, Hagan S, Pietrofesa R, Dukes F, et al. Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice. BMC Cancer. 2011;11:269.
13. Lee JC, Kinniry PA, Arguiri E, Serota M, Kanterakis S, Chatterjee S, et al. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat Res. 2010;173(5):590-601.
14. Lee JC, Krochak R, Blouin A, Kanterakis S, Chatterjee S, Arguiri E, et al. Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury. Cancer Biol Ther. 2009;8(1):47-53.
15. Lee JC, Bhora F, Sun J, Cheng G, Arguiri E, Solomides CC, et al. Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2008;294(2):L255-65.
16. Calder PC. omega 3 polyunsaturated fatty acids, inflammation and immunity. World Rev Nutr Diet. 2001;88:109-16.
17. Kitts DD, Yuan YV, Wijewickreme AN, Thompson LU. Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol Cell Biochem. 1999;202(1-2):91-100.
18. Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT, et al. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3577-87.
19. Mani UV, Mani I, Biswas M, Kumar SN. An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. J Diet Suppl. 2011;8(3):257-65.
20. Nesbitt PD, Lam Y, Thompson LU. Human metabolism of mammalian lignan precursors in raw and processed flaxseed. Am J Clin Nutr. 1999;69(3):549-55.
21. Thompson LU, Rickard SE, Cheung F, Kenaschuk EO, Obermeyer WR. Variability in anticancer lignan levels in flaxseed. Nutr Cancer. 1997;27(1):26-30.
22. Lawson JA, Li H, Rokach J, Adiyaman M, Hwang SW, Khanapure SP, et al. Identification of two major F2 isoprostanes, 8,12-iso- and 5-epi-8, 12-iso-isoprostane F2alpha-VI, in human urine. J Biol Chem. 1998;273(45):29295-301.
23. Weimann A, Belling D, Poulsen HE. Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography-electrospray tandem mass spectrometry. Nucleic Acids Res. 2002;30(2), E7.
24. Collins CE, Quaggiotto P, Wood L, O'Loughlin EV, Henry RL, Garg ML. Elevated plasma levels of F2 alpha isoprostane in cystic fibrosis. Lipids. 1999;34(6):551-6.
25. Park JH, Gopishetty S, Szewczuk LM, Troxel AB, Harvey RG, Penning TM. Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling. Chem Res Toxicol. 2005;18(6):1026-37.
26. Gullett NP, Ruhul Amin AR, Bayraktar S, Pezzuto JM, Shin DM, Khuri FR, et al. Cancer prevention with natural compounds. Semin Oncol. 2010;37(3):258-81.
27. Mangal D, Vudathala D, Park JH, Lee SH, Penning TM, Blair IA. Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress. Chem Res Toxicol. 2009;22(5):788-97.
28. Berman AT, Turowski J, Mick R, Cengel K, Farnese N, Basel-Brown L, et al. Phase I Randomized Trial of Dietary Flaxseed in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation. J Pulm Respir Med. 2013;3(4):154.
29. Saarinen NM, Thompson LU. Prolonged administration of secoisolariciresinol diglycoside increases lignan excretion and alters lignan tissue distribution in adult male and female rats. Br J Nutr. 2010;104(6):833-41.
30. Rickard SE, Orcheson LJ, Seidl MM, Luyengi L, Fong HH, Thompson LU. Dose-dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed. J Nutr. 1996;126(8):2012-9.
31. Rickard SE, Thompson LU. Chronic exposure to secoisolariciresinol diglycoside alters lignan disposition in rats. J Nutr. 1998;128(3):615-23.
32. Spira A, Beane J, Schembri F, Liu G, Ding C, Gilman S, et al. Noninvasive method for obtaining RNA from buccal mucosa epithelial cells for gene expression profiling. Biotechniques. 2004;36(3):484-7.
33. Kupfer DM, White VL, Jenkins MC, Burian D. Examining smoking-induced differential gene expression changes in buccal mucosa. BMC Med Genet. 2010;3:24.
34. Bhatia AL, Jain M. Spinacia oleracea L. protects against gamma radiations: a study on glutathione and lipid peroxidation in mouse liver. Phytomedicine. 2004;11(7-8):607-15.
35. Spira A. Upper airway gene expression in smokers: the mouth as a "window to the soul" of lung carcinogenesis? Cancer Prev Res. 2010;3(3):255-8.
36. Sridhar S, Schembri F, Zeskind J, Shah V, Gustafson AM, Steiling K, et al. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. BMC Genomics. 2008;9:259.