Barriers and opportunities for enhancing patient recruitment and retention in clinical research: Findings from an interview study in an NHS academic health science centre

Health Research Policy and Systems

Volumn 13, Issue 1, 2015, Pages

  Adams, Mary ^a   Caffrey, Louise ^a   McKevitt, Christopher ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Academic Health Science Centres; Barriers and opportunities to patient recruitment; Clinical research awareness; Clinical research subjects; Clinical research teams; Interface of clinical research and care; NIHR recruitment to research policy; Patient recruitment to clinical research; Personal research benefit; Qualitative research

Indexed keywords

ARTICLE; CLINICAL RESEARCH; COST BENEFIT ANALYSIS; FUNDING; HEALTH SCIENCE; HUMAN; PATIENT PARTICIPATION; PATIENT RECRUITMENT; PATIENT RETENTION; PATIENT SAFETY; QUALITATIVE RESEARCH; SEMI STRUCTURED INTERVIEW; TENSION; THEMATIC ANALYSIS; WORKLOAD; ECONOMICS; INTERVIEW; MEDICAL RESEARCH; NATIONAL HEALTH SERVICE; PATIENT DROPOUT; PATIENT SELECTION; UNITED KINGDOM;

BIOMEDICAL RESEARCH; HUMANS; INTERVIEWS AS TOPIC; PATIENT DROPOUTS; PATIENT SELECTION; QUALITATIVE RESEARCH; STATE MEDICINE; UNITED KINGDOM;

EID: 84929316484     PISSN: None     EISSN: 14784505     Source Type: Journal    
DOI: 10.1186/1478-4505-13-8     Document Type: Article

References (44)

1. Department of Health: Health and social care act. London: Stationary Office; 2012. https://www.gov.uk/government/publications/health-and-social-care-act-2012-fact-sheets
2. UK Clinical Trials Gateway: Public and patient survey. Southampton: NIHR; 2012. http://www.nihr.ac.uk/documents/about-NIHR/NIHR-Publications/UKCTG-Report-Public-and-Patient-Survey-Report-2012.pdf
3. Watson JM, Torgerson DJ: Increasing recruitment to randomised trials: a review of randomised controlled trials. BMC Med Res Methodol 2006, 6:34. 10.1186/1471-2288-6-34
4. Oude Rengerink K, Opmeer BC, Logtenberg SL, Hooft L, Bloemenkamp KW, Haak MC, et al.: Improving participation of patients in clinical trials - rationale and design of IMPACT. BMC Med Res Methodol 2010,10(1):85. 10.1186/1471-2288-10-85
5. Fletcher B, Gheorghe A, Moore D, Wilson S, Damery S: Improving the recruitment activity of clinicians in randomised controlled trials: a systematic review. BMJ Open 2012,2(1):e000496.
6. Jenkins VA, Farewell D, Farewell V, Batt L, Wagstaff J, Langridge C, et al.: Teams Talking Trials: results of an RCT to improve the communication of cancer teams about treatment trials. Contemp Clin Trials 2013,35(1):43-51. 10.1016/j.cct.2013.02.003
7. Campbell MK, Snowdon C, Francis D, Elbourne D, McDonald AM, Knight R, et al.: Recruitment to randomized trials: strategies for trial enrolment and participation study. The STEPS study. Health Technol Assess 2007,11(48):iii-72.
8. McDonald AM, Treweek S, Shakur H, Free C, Knight R, Speed C, et al.: Using a business model approach and marketing techniques for recruitment to clinical trials. Trials 2011, 12:74. 10.1186/1745-6215-12-74
9. Ennis L, Wykes T: Impact of patient involvement in mental health research: longitudinal study. Br J Psychiatry 2013,203(5):381-6. 10.1192/bjp.bp.112.119818
10. Mills N, Donovan JL, Wade J, Hamdy FC, Neal DE, Lane JA: Exploring treatment preferences facilitated recruitment to randomized controlled trials. J Clin Epidemiol 2011,64(10):1127-36. 10.1016/j.jclinepi.2010.12.017
11. Ulrich CM, Knafl KA, Ratcliffe SJ, Richmond TS, Grady C, Miller-Davis C, et al.: Developing a model of the benefits and burdens of research participation in cancer clinical trials. AJOB Prim Res 2012,3(2):10-23. 10.1080/21507716.2011.653472
12. Darbyshire JL, Price HC: Disseminating results to clinical trial participants: a qualitative review of patient understanding in a post-trial population. BMJ Open 2012, 2:e001252.
13. Hollada J, Marfori W, Tognolini A, Speier W, Ristow L, Ruehm SG: Successful patient recruitment in CT imaging clinical trials: what factors influence patient participation? Acad Radiol 2014,21(1):52-7. 10.1016/j.acra.2013.09.016
14. Thoma A, Farrokhyar F, McKnight L, Bhandari M: Practical tips for surgical research: how to optimize patient recruitment. Can J Surg 2010,53(3):205-10.
15. Ross S, Grant A, Counsell C, Gillespie W, Russell I, Prescott R: Barriers to participation in randomised controlled trials: a systematic review. J Clin Epidemiol 1999,52(12):1143-56. 10.1016/S0895-4356(99)00141-9
16. Thomson CL, Morley KC, Teesson M, Sannibale C, Haber PS: Issues with recruitment to randomised controlled trials in the drug and alcohol field: a literature review and Australian case study. Drug and Alcohol Rev 2008,27(2):115-22. 10.1080/09595230701829561
17. Abraham NS, Young JM, Solomon MF: A systematic review of reasons for no entry of eligible patients into surgical randomized controlled trials. Surgery 2006,139(4):469-83. 10.1016/j.surg.2005.08.014
18. Kirkby HM, Calvert M, Draper H, Keeley T, Wilson S: What potential research participants want to know about research: a systematic review. BMJ Open 2012,2(3):e000509.
19. Donovan J, Mills N, Smith M, Brindle L, Jacoby A, Peters T, et al.: Improving design and conduct of randomised trials by embedding them in qualitative research: ProtecT (prostate testing for cancer and treatment) study. BMJ 2002,325(7367):766-70. 10.1136/bmj.325.7367.766
20. Mills N, Donovan JL, Smith M, Jacoby A, Neal DE, Hamdy FC: Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT study. Control Clin Trials 2003,24(3):272-82. 10.1016/S0197-2456(03)00020-5
21. Paramasivan S, Huddart R, Hall E, Lewis R, Birtle A, Donovan JL: Key issues in recruitment to randomised controlled trials with very different interventions: a qualitative investigation of recruitment to the SPARE trial (CRUK/07/011). Trials 2011,12(1):78. 10.1186/1745-6215-12-78
22. de Salis I, Tomlin Z, Toerien M, Donovan J: Using qualitative research methods to improve recruitment to randomized controlled trials: the Quartet study. J Health Serv Res Policy 2008,13(3):92-6.
23. Donovan JL, Lane JA, Peters TJ, Brindle L, Salter E, Gillatt D, et al.: Development of a complex intervention improved randomization and informed consent in a randomized controlled trial. J Clin Epidemiol 2009,62(1):29-36. 10.1016/j.jclinepi.2008.02.010
24. Hamilton DW, de Salis I, Donovan J, Birchall M: The recruitment of patients to trials in head and neck cancer: a qualitative study of the EaStER trial of treatments for early laryngeal cancer. Eur Arch Otorhinolaryngol 2013,270(8):2333-7. 10.1007/s00405-013-2349-8
25. Probstfield J, Frye RL: Strategies for recruitment and retention of participants in clinical trials. JAMA 2011,306(16):1798-9.
26. NIHR Clinical Research Network: Activity based funding project 2010/11. Southampton: NIHR; 2011.
27. Association of Medical Research Charities: Our vision for research in the NHS. London: AMRC; 2013.
28. Patterson S, Mairs H, Borschmann R: Successful recruitment to trials: a phased approach to opening gates and building bridges. BMC Med Res Methodol 2011,11(1):73. 10.1186/1471-2288-11-73
29. Preston NJ, Farquhar MC, Walshe CE, Stevinson C, Ewing G, Calman LA, et al.: Strategies to increase participant recruitment to research studies by healthcare professionals (Protocol). Cochrane Database Syst Rev 2012, 9:MR000036.
30. Ford E, Jenkins V, Fallowfield L, Stuart N, Farewell D, Farewell V: Clinicians' attitudes towards clinical trials of cancer therapy. Br J Cancer 2011,104(10):1535-43. 10.1038/bjc.2011.119
31. Donovan J, Parmasivan S, de Salis I, Torrien M: Clear obstacles and hidden challenges: understanding recruiter perspectives in six pragmatic randomised controlled trials. Trials 2014,15(1):5. 10.1186/1745-6215-15-5
32. Hamilton M, Genge A, Johnston M, Lam D, Mobach T, Marriott J, et al.: Patient recruitment by neurological registries. Can J Neurol Sci 2013,40(Suppl 2):S23-6.
33. Spaar A, Frey M, Turk A, Karrer W, Puhan MA: Recruitment barriers in a randomized controlled trial from the physicians' perspective - a postal survey. BMC Med Res Methodol 2009,9(1):14. 10.1186/1471-2288-9-14
34. Carpenter JS, Ziner K: A process to manage recruitment to multiple competing studies. West J Nurs Res 2008,30(4):515-26.
35. Cuggia CM, Besana P, Glasspool D: Comparing semi-automatic systems for recruitment to clinical trials. Int J Med Inform 2011,80(6):371-88. 10.1016/j.ijmedinf.2011.02.003
36. Cameron D, Stead M, Lester N, Parmar M, Haward R, Maughan T, et al.: Research-intensive cancer care in the NHS in the UK. Ann Oncol 2001,22(Suppl 7):vii29-35.
37. Rhymes C: National Institute for Health Research leading the way for neurosciences research. J Neurol Neurosurg Psychiatry 2012, 83:e1.
38. Treweek S, Pitkethly M, Cook J, Kjeldstrøm M, Taskila T, Johansen M, et al.: Strategies to improve recruitment to randomised controlled trials. Cochrane Database Syst Rev 2010,14(4):MR000013.
39. Gul RB, Ali PA: Clinical trials: the challenge of recruitment and retention of participants. J Clin Nurs 2010,19(1-2):227-33.
40. National Institute of Health Research: CRN annual performance report 2011/12. Southampton: NIHR; 2012.
41. Bryman A: Social research methods. New York: Oxford University Press; 2008.
42. Ritchie J, Spencer L, O'Connor W: Carrying out qualitative analysis. In Qualitative research practice. 3rd edition. Edited by: Ritchie J, Lewis J. London: Sage Publications; 2010:237.
43. Ritchie J, Spencer L, O'Connor W: Carrying out qualitative analysis. In Qualitative research practice. 3rd edition. Edited by: Ritchie J, Lewis J. London: Sage Publications; 2010:248.
44. National Institute of Health Research Clinical Research Network: Mystery shopper report. Southampton: NIHR; 2013. http://www.crn.nihr.ac.uk/can-help/healthcare-professionals/mystery-shopper/