SAR and structural analysis of siderophore-conjugated monocarbam inhibitors of pseudomonas aeruginosa PBP3

ACS Medicinal Chemistry Letters

Volumn 6, Issue 5, 2015, Pages 537-542

  Murphy Benenato, Kerry E ^a,b   Dangel, Brian ^a,c   Davis, Hajnalka E ^a   Durand Réville, Thomas F ^a   Ferguson, Andrew D ^a   Gao, Ning ^a   Jahić, Haris ^a   Mueller, John P ^a   Manyak, Erika L ^a,d   Quiroga, Olga ^a   Rooney, Michael ^a   Sha, Li ^a   Sylvester, Mark ^a   Wu, Frank ^a   Zambrowski, Mark ^a,e   Zhao, Shannon X ^a  

^a ASTRAZENECA   (United Kingdom)

^b MODERNA THERAPEUTICS   (United States)

^c Life Sciences Solutions Thermo Scientific Inc   (United States)

^d AGIOS PHARMACEUTICALS   (United States)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

monocarbam; penicillin binding protein; Pseudomonas aeruginosa; siderophore; structure guided design; lactam

Indexed keywords

ANTIINFECTIVE AGENT; METALLO BETA LACTAMASE; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 3; SIDEROPHORE; U 78608; UNCLASSIFIED DRUG;

ACYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; CYTOPLASM; DRUG STRUCTURE; HYDROGEN BOND; IRON TRANSPORT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

PSEUDOMONAS AERUGINOSA;

EID: 84929313649     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00026     Document Type: Article

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