Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 18, 2012, Pages 5989-5994

  Mitton Fry, Mark J ^a   Arcari, Joel T ^a   Brown, Matthew F ^a   Casavant, Jeffrey M ^a   Finegan, Steven M ^a   Flanagan, Mark E ^a   Gao, Hongying ^a   George, David M ^a   Gerstenberger, Brian S ^a   Han, Seungil ^a   Hardink, Joel R ^a   Harris, Thomas M ^a   Hoang, Thuy ^a   Huband, Michael D ^a   Irvine, Rebecca ^a   Lall, Manjinder S ^a   Megan Lemmon, M ^a   Li, Chao ^a   Lin, Jian ^a   McCurdy, Sandra P ^a   Mueller, John P ^a   Mullins, Lisa ^a   Niosi, Mark ^a   Noe, Mark C ^a   Pattavina, David ^a   Penzien, Joseph ^a   Plummer, Mark S ^a   Risley, Hud ^a   Schuff, Brandon P ^a   Shanmugasundaram, Veerabahu ^a   Starr, Jeremy T ^a   Sun, Jianmin ^a   Winton, Jennifer ^a   Young, Jennifer A ^a   more..

^a PFIZER INC   (United States)

Author keywords

Escherichia coli; Gram negative; Klebsiella pneumoniae; MC 1; Monobactam; Pseudomonas aeruginosa; Siderophore

Indexed keywords

AZTREONAM; MEROPENEM; MONOBACTAM DERIVATIVE; PIRAZMONAM; SIDEROPHORE; U 78608;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; DRUG OXIDATION; DRUG PENETRATION; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; IRON TRANSPORT; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA; RAT; SAPONIFICATION; STRUCTURE ACTIVITY RELATION; SULFONATION;

ANIMALS; BINDING SITES; BLOOD PROTEINS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOBACTAMS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 84865519152     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.005     Document Type: Article

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