Effect of different intestinal conditions on the intermolecular interaction between insulin and cell-penetrating peptide penetratin and on its contribution to stimulation of permeation through intestinal epithelium

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 94, Issue , 2015, Pages 42-51

  Kamei, Noriyasu ^a   Aoyama, Yukina ^a   Khafagy, El Sayed ^a,b   Henmi, Mao ^a   Takeda Morishita, Mariko ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b Suez Canal University   (Egypt)

Author keywords

Caco 2 cells; Cell penetrating peptide; Insulin; Intermolecular interaction; Oral absorption; Penetratin

Indexed keywords

PENETRATIN; PHOSPHATIDYLCHOLINE; RECOMBINANT HUMAN INSULIN; TAUROCHOLIC ACID; ANTIDIABETIC AGENT; CARRIER PROTEIN; DRUG CARRIER; INSULIN; PROTEIN BINDING;

APPARENT PERMEABILITY; ARTICLE; CACO 2 CELL LINE; CHEMICAL COMPOSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE FLUID; INTESTINE MUCOSA PERMEABILITY; PH; PROTEIN INTERACTION; TIGHT JUNCTION; BIOLOGICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; EPITHELIUM CELL; INTESTINE MUCOSA; KINETICS; MEDICINAL CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; PERMEABILITY; PHARMACEUTICS; PROCEDURES;

ADMINISTRATION, ORAL; CACO-2 CELLS; CARRIER PROTEINS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EPITHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; KINETICS; LECITHINS; MODELS, BIOLOGICAL; PERMEABILITY; PROTEIN BINDING; TAUROCHOLIC ACID; TECHNOLOGY, PHARMACEUTICAL; TIGHT JUNCTIONS;

EID: 84929310969     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.04.030     Document Type: Article

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