Age-related aspects of cutaneous wound healing: A mini-review

Gerontology

Volumn 59, Issue 2, 2013, Pages 159-164

  Sgonc, Roswitha ^a   Gruber, Johann ^b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Aging; Collagen synthesis; Cutaneous wound healing; Repair process

Indexed keywords

ELASTIN; EPIDERMAL GROWTH FACTOR; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; PLATELET DERIVED GROWTH FACTOR; PRASTERONE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

AGING; ANGIOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CUTANEOUS PARAMETERS; CYTOKINE RELEASE; DOWN REGULATION; EXTRACELLULAR MATRIX; FIBRIN CLOT; FIBROBLAST; GRANULATION TISSUE; HEMOSTASIS; HUMAN; KERATINOCYTE; LYMPHOCYTIC INFILTRATION; MYOFIBROBLAST; NEUTROPHIL CHEMOTAXIS; NUTRITION; PHENOTYPE; POSTMENOPAUSE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; WOUND HEALING; WOUND HEALING IMPAIRMENT; AGED; INFLAMMATION; SENESCENCE; SKIN INJURY;

AGED; AGING; HUMANS; RE-EPITHELIALIZATION; SKIN; SKIN AGING; WOUND HEALING;

EID: 84874765970     PISSN: 0304324X     EISSN: 14230003     Source Type: Journal    
DOI: 10.1159/000342344     Document Type: Review

References (24)

1. Shaw TJ, Martin P: Wound repair at a glance. J Cell Sci 2009; 122: 3209-3213.
2. Du Noüy PL: Cicatrization of wounds. III. The relation between the age of the patient, the area of the wound, and the index of cicatrization. J Exp Med 1916; 24: 461-470.
3. Eming SA, Krieg T, Davidson JM: Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007; 127: 514-525.
4. Zouboulis CC, Makrantonaki E: Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol 2011; 29: 3-14.
5. Ashcroft GS, Mills SJ, Ashworth JJ: Ageing and wound healing. Biogerontology 2002; 3: 337-345.
6. Gouin JP, Hantsoo L, Kiecolt-Glaser JK: Immune dysregulation and chronic stress among older adults: a review. Neuroimmunomodulation 2008; 15: 251-259.
7. Ashcroft GS, Horan MA, Ferguson MW: Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing. Lab Invest 1998; 78: 47-58.
8. Mirza R, DiPietro LA, Koh TJ: Selective and specific macrophage ablation is detrimental to wound healing in mice. Am J Pathol 2009; 175: 2454-2462.
9. Lucas T, Waisman A, Ranjan R, Roes J, Krieg T, Müller W, Roers A, Eming SA: Differential roles of macrophages in diverse phases of skin repair. J Immunol 2010; 184: 3964-3977.
10. Swift ME, Burns AL, Gray KL, DiPietro LA: Age-related alterations in the inflammatory response to dermal injury. J Invest Dermatol 2001; 117: 1027-1035.
11. Swift ME, Kleinman HK, DiPietro LA: Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest 1999; 79: 1479- 1487.
12. Loh SA, Chang EI, Galvez MG, Thangarajah H, El-ftesi S, Vial IN, Lin DA, Gurtner GC: SDF-1 alpha expression during wound healing in the aged is HIF dependent. Plast Reconstr Surg 2009; 123(2 suppl):65S-75S.
13. Xia YP, Zhao Y, Tyrone JW, Chen A, Mustoe TA: Differential activation of migration by hypoxia in keratinocytes isolated from donors of increasing age: implication for chronic wounds in the elderly. J Invest Dermatol 2001; 116: 50-56.
14. Mogford JE, Tawil N, Chen A, Gies D, Xia Y, Mustoe TA: Effect of age and hypoxia on TGFbeta1 receptor expression and signal transduction in human dermal fibroblasts: impact on cell migration. J Cell Physiol 2002; 190: 259-265.
15. Chang EI, Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, Aarabi S, Chan DA, Freedman ML, Giaccia AJ, Gurtner GC: Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation 2007; 116: 2818-2829.
16. Zhang X, Sarkar K, Rey S, Sebastian R, Andrikopoulou E, Marti GP, Fox-Talbot K, Semenza GL, Harmon JW: Aging impairs the mobilization and homing of bone marrowderived angiogenic cells to burn wounds. J Mol Med 2011; 89: 985-995.
17. Reed MJ, Karres N, Eyman D, Vernon RB, Edelberg JM: Age-related differences in repair of dermal wounds and myocardial infarcts attenuate during the later stages of healing. In Vivo 2006; 20: 801-806.
18. Bond JS, Duncan JA, Sattar A, Boanas A, Mason T, O'Kane S, Ferguson MW: Maturation of the human scar: an observational study. Plast Reconstr Surg 2008; 121: 1650-1658.
19. Hardman MJ, Ashcroft GS: Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly. Genome Biol 2008; 9:R80.
20. Hunt ND, Li GD, Zhu M, Miller M, Levette A, Chachich ME, Spangler EL, Allard JS, Hyun DH, Ingram DK, de Cabo R: Effect of calorie restriction and refeeding on skin wound healing in rats. Age 2011; DOI: 10.1007/s11357-011-9321- 6.
21. Mathus-Vliegen EM: Old age, malnutrition, and pressure sores: an ill-fated alliance. J Gerontol A Biol Sci Med Sci 2004; 59: 355- 360.
22. Hofman D, Moore K, Cooper R, Eagle M, Cooper S: Use of topical corticosteroids on chronic leg ulcers. J Wound Care 2007; 16: 227-230.
23. Wagner AE, Huck G, Stiehl DP, Jelkmann W, Hellwig-Bürgel T: Dexamethasone impairs hypoxia-inducible factor-1 function. Biochem Biophys Res Commun 2008; 372: 336- 340.
24. Franz MG, Steed DL, Robson MC: Optimizing healing of the acute wound by minimizing complications. Curr Probl Surg 2007; 44: 691-763.