Derivation of normal diploid human embryonic stem cells from tripronuclear zygotes with analysis of their copy number variation and loss of heterozygosity

Molecular Reproduction and Development

Volumn 82, Issue 5, 2015, Pages 344-355

  Chen, Xuemei ^a,b   Niu, Wenbin ^a   Wang, Fang ^a   Yu, Wenzhu ^a   Dai, Shanjun ^a   Kong, Huijuan ^a   Shu, Yimin ^c   Sun, Yingpu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CELL ANTIGEN; GENOMIC DNA; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BLASTOCYST; CELL DIFFERENTIATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DIPLOIDY; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVITY; FEEDER CELL; FERTILIZATION IN VITRO; FIBROBLAST; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRAIT; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; INNER CELL MASS; INTRACYTOPLASMIC SPERM INJECTION; KARYOTYPE 46,XY; MICROARRAY ANALYSIS; MOSAICISM; MOUSE; NONHUMAN; PREPUCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRIPRONUCLEAR ZYGOTE; ZYGOTE; ANIMAL; CELL CULTURE; CELL CULTURE TECHNIQUE; CELL NUCLEUS; CYTOLOGY; EMBRYO CULTURE; GENETICS; HUMAN EMBRYONIC STEM CELL; IN VITRO FERTILIZATION; KARYOTYPING; METABOLISM; PHYSIOLOGY; PROCEDURES;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL NUCLEUS; CELLS, CULTURED; DIPLOIDY; DNA COPY NUMBER VARIATIONS; EMBRYO CULTURE TECHNIQUES; FERTILIZATION IN VITRO; HUMAN EMBRYONIC STEM CELLS; HUMANS; KARYOTYPING; LOSS OF HETEROZYGOSITY; MICE; SPERM INJECTIONS, INTRACYTOPLASMIC; ZYGOTE;

EID: 84929297702     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.22485     Document Type: Article

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