Loss of heterozygosity at the calcium regulation gene locus on chromosome 10q in human pancreatic cancer

Asian Pacific Journal of Cancer Prevention

Volumn 16, Issue 6, 2015, Pages 2489-2493

  Long, Jin ^a   Zhang, Zhong Bo ^a   Liu, Zhe ^a   Xu, Yuan Hong ^a   Ge, Chun Lin ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Loss of heterozygosity; Pancreatic cancer; Single nucleotide polymorphism

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM CHANNEL; CARRIER PROTEIN; CATION TRANSPORT PROTEIN; LIVER-SPECIFIC ZP DOMAIN-CONTAINING PROTEIN, HUMAN; MEMBRANE PROTEIN; MICU1 PROTEIN, HUMAN; MITOCHONDRIAL CALCIUM UNIPORTER;

CALCIUM SIGNALING; CHROMOSOME 10; COMPARATIVE STUDY; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENE ONTOLOGY; GENETICS; HETEROZYGOSITY LOSS; HUMAN; METABOLISM; PANCREAS; PANCREAS TUMOR; PATHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

CALCIUM CHANNELS; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CATION TRANSPORT PROTEINS; CHROMOSOMES, HUMAN, PAIR 10; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE ONTOLOGY; HUMANS; LOSS OF HETEROZYGOSITY; MEMBRANE PROTEINS; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREAS; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84929192235     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2015.16.6.2489     Document Type: Article

References (39)

1. Amaya K, Ohta T, Kitagawa H, et al (2004). Angiotensin II activates MAP kinase and NF-kB through angiotensin II type I receptor in human pancreatic cancer cells. Int J Oncol, 25, 849-56.
2. Arvizo RR, Moyano DF, Saha S, et al (2013). Probing novel roles of the mitochondrial uniporter in ovarian cancer cells using nanoparticles. J Biol Chem, 288, 17610-8.
3. Baker DJ, Jin F, Jeganathan KB, et al (2009). Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer cell, 16, 475-86.
4. Baughman JM, Perocchi F, Girgis HS, et al (2011). Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature, 476, 341-5.
5. Beroukhim R, Lin M, Park Y, et al (2006). Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays. PLoS Comput Biol, 2, 41.
6. Bick AG, Calvo SE, Mootha VK (2012). Evolutionary diversity of the mitochondrial calcium uniporter. Science, 336, 886.
7. Butz J, Wickstrom E, Edwards J (2003). Characterization of mutations and loss of heterozygosity of p53 and K-ras2 in pancreatic cancer cell lines by immobilized polymerase chain reaction. BMC Biotechnol, 3, 11.
8. Chen K, Hsu L-T, Wu C-Y, et al (2013). CBARA1 plays a role in stemness and proliferation of human embryonic stem cells. PloS One, 8, 63653.
9. Contreras L, Drago I, Zampese E, et al (2010). Mitochondria: the calcium connection. BBA-Gen Subjects, 1797, 607-18.
10. Csordas G, Golenar T, Seifert EL, et al (2013). MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca2+ uniporter. Cell Metab, 17, 976-87.
11. Csordas G, Varnai P, Golenar T, et al (2012). Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. Mol Cell Endocrinol, 353, 109-13.
12. Curry MC, Peters AA, Kenny PA, et al (2013). Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun, 434, 695-700.
13. Day IN (2010). dbSNP in the detail and copy number complexities. Hum Mutat, 31, 2-4.
14. Donahue TR, Tran LM, Hill R, et al (2012). Integrative survival-based molecular profiling of human pancreatic cancer. Clin Cancer Res, 18, 1352-63.
15. Elnemr A, Ohta T, Iwata K, et al (2000). PPARgamma ligand (thiazolidinedione) induces growth arrest and differentiation markers of human pancreatic cancer cells. Int J Oncol, 17, 1157-221.
16. Frampton SJ, King EV (2013). Loss of heterozygosity. in 'encyclopedia of otolaryngology, head and neck surgery', Eds Springer, 1488
17. Franko J, Krasinskas AM, Nikiforova MN, et al (2008). Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma. J Gastrointest Surg, 12, 1664-73.
18. Fujita PA, Rhead B, Zweig AS, et al (2010). The UCSC genome browser database: update 2011. Nucleic Acids Res, 963.
19. Hoffman NE, Chandramoorthy HC, Shamugapriya S, et al (2013). MICU1 motifs define mitochondrial calcium uniporter binding and activity. Plant Cell Rep, 5, 1576-88.
20. Kohl M, Wiese S, Warscheid B (2011). Cytoscape: software for visualization and analysis of biological networks., Eds Springer, 696, 291-303
21. Kopp JL, von Figura G, Mayes E, et al (2012). Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell, 22, 737-50.
22. Kroemer G, Galluzzi L, Brenner C (2007). Mitochondrial membrane permeabilization in cell death. Physiol Rev, 87, 99-163.
23. Lin L-J, Asaoka Y, Tada M, et al (2008). Integrated analysis of copy number alterations and loss of heterozygosity in human pancreatic cancer using a high-resolution, single nucleotide polymorphism array. Oncol, 75, 102-12.
24. Logan CV, Szabadkai G, Sharpe JA, et al (2014). Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nat Genet, 46, 188-93.
25. Lucas AL, Shakya R, Lipsyc MD, et al (2013). High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions. Clin Cancer Res, 19, 3396-403.
26. Mallilankaraman K, Doonan P, Cardenas C, et al (2012). MICU1 Is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival. Cell, 151, 630-44.
27. Marchi S, Lupini L, Patergnani S, et al (2013). Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25. Curr Biol, 23, 58-63.
28. Morton JP, Timpson P, Karim SA, et al (2010). Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci, 107, 246-51.
29. Patron M, Raffaello A, Granatiero V, et al (2013). The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles. J Biol Chem, 288, 10750-8.
30. Perocchi F, Gohil VM, Girgis HS, et al (2010). MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake. Nature, 467, 291-6.
31. Raffaello A, De Stefani D, Rizzuto R (2012). The mitochondrial Ca2+ uniporter. Cell Calcium, 52, 16-21.
32. Sahu RP, Srivastava SK (2009). The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J Natl Cancer Inst, 101, 176-93.
33. Sato Y, Nio Y, Song M, et al (1996). p53 protein expression as prognostic factor in human pancreatic cancer. Anticancer Res, 17, 2779-88.
34. Scorrano L, Oakes SA, Opferman JT, et al (2003). BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science, 300, 135-9.
35. Sherman BT, Huang DW, Tan Q, et al (2007). DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis. BMC Bioinformatics, 8, 426.
36. Staaf J, Lindgren D, Vallon-Christersson J, et al (2008). Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays. Genome Biol, 9, 136.
37. Xu ZG, Du JJ, Zhang X, et al (2003). A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. Hepatology, 38, 735-44.
38. Yoshida T, Kobayashi T, Itoda M, et al (2010). Clinical omics analysis of colorectal cancer incorporating copy number aberrations and gene expression data. Cancer Informatics, 9, 147.
39. Zhang Y, Bharadwaj U, Logsdon CD, et al (2010). ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB. Clin Cancer Res, 16, 1423-30.