Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 19, 2015, Pages 6188-6193

  Dwyer, Jason M ^a   Maldonado Avilés, Jaime G ^a   Lepack, Ashley E ^a,b   DiLeone, Ralph J ^a   Duman, Ronald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Antidepressant; Prefrontal cortex; Rapamycin; Synapse; Translation

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RIBOSOMAL PROTEIN S6 KINASE 1; S6 KINASE; UNCLASSIFIED DRUG; ANTIDEPRESSANT AGENT; KETAMINE; RAPAMYCIN; S6K1 PROTEIN, RAT;

ANHEDONIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BEHAVIOR CONTROL; CHRONIC STRESS; CHRONIC UNPREDICTABLE STRESS; COPING BEHAVIOR; DEPRESSION; EMBRYO; FORCED SWIM TEST; GENE TARGETING; HEK293 CELL LINE; LOCOMOTION; MAJOR DEPRESSION; MALE; MAZE TEST; MOLECULAR PATHOLOGY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; VIRAL GENE THERAPY; VIRUS PARTICLE; ANIMAL; ANIMAL BEHAVIOR; CHEMISTRY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; PHENOTYPE; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SWIMMING;

RATTUS;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DEPRESSIVE DISORDER, MAJOR; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KETAMINE; MALE; MAZE LEARNING; NEURONS; PHENOTYPE; PHOSPHORYLATION; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SIROLIMUS; SWIMMING;

EID: 84929179463     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505289112     Document Type: Article

References (22)

1. Kessler RC, et al.; National Comorbidity Survey Replication (2003) The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). JAMA 289(23):3095-3105.
2. Li N, et al. (2010) mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329(5994):959-964.
3. Dwyer JM, Lepack AE, Duman RS (2012) mTOR activation is required for the antidepressant effects of mGluR2/3 blockade. Int J Neuropsychopharmacol 15(4):429-434.
4. Voleti B, et al. (2013) Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses. Biol Psychiatry 74(10):742-749.
5. Schalm SS, Blenis J (2002) Identification of a conserved motif required for mTOR signaling. Curr Biol 12(8):632-639.
6. Hommel JD, Sears RM, Georgescu D, Simmons DL, DiLeone RJ (2003) Local gene knock-down in the brain using viral-mediated RNA interference. Nat Med 9(12):1539-1544.
7. Schmidt EK, Clavarino G, Ceppi M, Pierre P (2009) SUnSET, a nonradioactive method to monitor protein synthesis. Nat Methods 6(4):275-277.
8. Bodnoff SR, Suranyi-Cadotte B, Quirion R, Meaney MJ (1989) A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety. Psychopharmacology (Berl) 97(2):277-279.
9. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 93(3):358-364.
10. Zhong P, et al. (2014) Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling. Neuropsychopharmacology 39(7): 1763-1776.
11. Ota KT, et al. (2014) REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nat Med 20(5):531-535.
12. Cook SC, Wellman CL (2004) Chronic stress alters dendritic morphology in rat medial prefrontal cortex. J Neurobiol 60(2):236-248.
13. Liston C, et al. (2006) Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting. J Neurosci 26(30):7870-7874.
14. Liu RJ, Aghajanian GK (2008) Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy. Proc Natl Acad Sci USA 105(1):359-364.
15. Radley JJ, et al. (2006) Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. Cereb Cortex 16(3):313-320.
16. Watanabe Y, Gould E, McEwen BS (1992) Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res 588(2):341-345.
17. Wellman CL (2001) Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. J Neurobiol 49(3):245-253.
18. Kang HJ, et al. (2012) Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nat Med 18(9):1413-1417.
19. Jernigan CS, et al. (2011) The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 35(7):1774-1779.
20. Li N, et al. (2011) Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry 69(8):754-761.
21. Sierra-Mercado D, Padilla-Coreano N, Quirk GJ (2011) Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology 36(2):529-538.
22. Vidal-Gonzalez I, Vidal-Gonzalez B, Rauch SL, Quirk GJ (2006) Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. Learn Mem 13(6):728-733.