Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 19, 2015, Pages E2497-E2506

  Takeuchi, Toshihide ^a,b   Suzuki, Mari ^a   Fujikake, Nobuhiro ^a   Popiel, H Akiko ^a   Kikuchi, Hisae ^a   Futaki, Shiroh ^b   Wada, Keiji ^a   Nagai, Yoshitaka ^a,c  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Exosome; Molecular chaperones; Non cell autonomous; Polyglutamine; Proteostasis

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; POLYGLUTAMINE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 90; PEPTIDE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DROSOPHILA; EXOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; ANIMAL; CELL LINE; CHEMISTRY; DEGENERATIVE DISEASE; DROSOPHILA MELANOGASTER; ELECTRON MICROSCOPY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HOMEOSTASIS; METABOLISM; MOUSE; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL LINE; DROSOPHILA; DROSOPHILA MELANOGASTER; EXOSOMES; HEAT-SHOCK PROTEINS; HOMEOSTASIS; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; MICE; MICROSCOPY, ELECTRON; MOLECULAR CHAPERONES; NEURODEGENERATIVE DISEASES; PEPTIDES; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84929176978     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412651112     Document Type: Article

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