Clinicopathologic characteristics and outcomes of renal thrombotic microangiopathy in anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis

Clinical Journal of the American Society of Nephrology

Volumn 10, Issue 5, 2015, Pages 750-758

  Chen, Su Fang ^a,b,c   Wang, Huan ^a,b,c   Huang, Yi Min ^a,b,c   Li, Zhi Ying ^a,b,c   Wang, Su Xia ^a,b,c   Yu, Feng ^a,b,c   Zhao, Ming Hui ^a,b,c,d   Chen, Min ^a,b,c  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b BEIJING HOSPITAL   (China)

^c Ministry of Education   (China)

^d Tsinghua University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DISINTEGRIN; METALLOPROTEINASE; METHYLPREDNISOLONE; NEUTROPHIL CYTOPLASMIC ANTIBODY; THROMBOSPONDIN 1; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; ADAM PROTEIN; ADAMTS13 PROTEIN, HUMAN; ANTIINFLAMMATORY AGENT; CREATININE; HEMOGLOBIN; IMMUNOSUPPRESSIVE AGENT;

AGED; ARTICLE; CELL SWELLING; CREATININE BLOOD LEVEL; DISSEMINATED INTRAVASCULAR CLOTTING; ELECTRON MICROSCOPY; END STAGE RENAL DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GLOMERULONEPHRITIS; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY FIBROSIS; KIDNEY INJURY; LUNG HEMORRHAGE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PROGNOSIS; RETROSPECTIVE STUDY; THROMBOTIC THROMBOCYTOPENIC PURPURA; ADULT; ANCA ASSOCIATED VASCULITIS; BLOOD; COMPLICATION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; RECURRENT DISEASE; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; THROMBOTIC MICROANGIOPATHIES; TREATMENT OUTCOME;

ADAM PROTEINS; ADAMTS13 PROTEIN; ADRENAL CORTEX HORMONES; ADULT; AGED; ANTI-INFLAMMATORY AGENTS; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; AZATHIOPRINE; CREATININE; CYCLOPHOSPHAMIDE; FEMALE; GLOMERULONEPHRITIS; HEMOGLOBINS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; METHYLPREDNISOLONE; MIDDLE AGED; PROGNOSIS; RECURRENCE; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; THROMBOTIC MICROANGIOPATHIES; TREATMENT OUTCOME;

EID: 84929169595     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.07910814     Document Type: Article

References (41)

1. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores- Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CG, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees AJ, Scott DG, Specks U, Stone JH, Takahashi K, Watts RA: 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 65: 1–11, 2013
2. Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K, Neumann I, Noel LH, Pusey CD, Waldherr R, Bruijn JA, Bajema IM: Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol 21: 1628–1636, 2010
3. Hirsch DJ, Jindal KK, Trillo AA: Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis and thrombotic microangiopathy. Am J Kidney Dis 26: 385–386, 1995
4. Lim HE, Jo SK, Kim SW, Choi HK, Suh IB, Yoon SY, Moon JS, Won NH, Kwon YJ, Pyo HJ: A case of Wegener’s granulomatosis complicated by diffuse pulmonary hemorrhage and thrombotic thrombocytopenic purpura. Korean J InternMed 13: 68–71, 1998
5. Stefanidis I, Helmchen U, Schmitt H, Maurin N, Sieberth HG: Coincidence of haemolytic uraemic syndrome and c-ANCAassociated rapidly progressive glomerulonephritis. Nephrol Dial Transplant 13: 1818–1821, 1998
6. Agrawal V, Vaidya CK, Ye J, Freeman J, McKiernan C, Blier PR, Andrzejewski C Jr, Germain M, Braden GL: Concomitant thrombotic thrombocytopenic purpura and ANCA-associated vasculitis in an adolescent. Pediatr Nephrol 26: 1317–1320, 2011
7. Nagai K, Kotani T, Takeuchi T, Shoda T, Hata-Kobayashi A, Wakura D, Kagitani M, Makino S, Hanafusa T: Successful treatment of thrombotic thrombocytopenic purpura with repeated plasma exchange in a patient with microscopic polyangitis. Mod Rheumatol 18: 643–646, 2008
8. Yamauchi Y, Nagatoya K, Okuno A, Fujii N, Inoue T: Successful treatment for thrombotic thrombocytopenic purpura complicated with myeloperoxidase anti-neutrophil cytoplasmic autoantibody- associated vasculitis. NDT Plus 3: 279–281, 2010
9. Asamiya Y, Moriyama T, Takano M, Iwasaki C, Kimura K, Ando Y, Aoki A, Kikuchi K, Takei T, Uchida K, Nitta K: Successful treatment with rituximab in a patient with TTP secondary to severe ANCA-associated vasculitis. Intern Med 49: 1587–1591, 2010
10. Abril A, Calamia KT, Cohen MD: The Churg Strauss syndrome (allergic granulomatous angiitis): Review and update. Semin Arthritis Rheum 33: 106–114, 2003
11. Zoltan GL, Fred GS: Hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, and other thrombotic microangiopathies. In: Hepinstall’s Pathology of the Kidney, 6th Ed., edited by Jennette JC, Olson JL, Schwartz MM, Silva FG, Philadelphia, Lippincott Williams & Wilkins, 2007, pp 711–717
12. Rick ME, Moll S, Taylor MA, Krizek DM, White GC II, Aronson DL: Clinical use of a rapid collagen binding assay for vonWillebrand factor cleaving protease in patients with thrombotic thrombocytopenic purpura. Thromb Haemost 88: 598–604, 2002
13. Bajema IM, Hagen EC, Hansen BE, Hermans J, Noel LH, Waldherr R, Ferrario F, van der Woude FJ, Bruijn JA: The renal histopathology in systemic vasculitis: An international survey study of inter- and intra-observer agreement. Nephrol Dial Transplant 11: 1989–1995, 1996
14. Bajema IM, Hagen EC, Hermans J, Noel LH, Waldherr R, Ferrario F, Van Der Woude FJ, Bruijn JA: Kidney biopsy as a predictor for renal outcome in ANCA-associated necrotizing glomerulonephritis. Kidney Int 56: 1751–1758, 1999
15. Hauer HA, Bajema IM, van Houwelingen HC, Ferrario F, Noel LH, Waldherr R, Jayne DR, Rasmussen N, Bruijn JA, Hagen EC; European Vasculitis Study Group (EUVAS): Renal histology in ANCA-associated vasculitis:Differences between diagnostic and serologic subgroups. Kidney Int 61: 80–89, 2002
16. Li ZY, Chang DY, Zhao MH, Chen M: Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibodyassociated vasculitis: A study of 439 cases in a single Chinese center. Arthritis Rheumatol 66: 1920–1926, 2014
17. Jennette JC: Rapidly progressive crescentic glomerulonephritis. Kidney Int 63: 1164–1177, 2003
18. Hellmich B, Flossmann O, Gross WL, Bacon P, Cohen-Tervaert JW, Guillevin L, Jayne D, Mahr A, Merkel PA, Raspe H, Scott DG, Witter J, Yazici H, Luqmani RA: EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: Focus on anti-neutrophil cytoplasm antibody-associated vasculitis. Ann Rheum Dis 66: 605–617, 2007
19. Hogan SL, Falk RJ, Chin H, Cai J, Jennette CE, Jennette JC, Nachman PH: Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis. Ann Intern Med 143: 621–631, 2005
20. Hogan SL, Nachman PH, Wilkman AS, Jennette JC, Falk RJ: Prognostic markers in patients with antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 7: 23–32, 1996
21. Nachman PH, Hogan SL, Jennette JC, Falk RJ: Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J AmSoc Nephrol 7: 33–39, 1996
22. Hauer HA, Bajema IM, Van Houwelingen HC, Ferrario F, Noel LH, Waldherr R, Jayne DR, Rasmussen N, Bruijn JA, Hagen EC; European Vasculitis Study Group (EUVAS): Determinants of outcome in ANCA-associated glomerulonephritis: A prospective clinico-histopathological analysis of 96 patients. Kidney Int 62: 1732–1742, 2002
23. Yu XJ, Yu F, Song D, Wang SX, Song Y, Liu G, Zhao MH: Clinical and renal biopsy findings predicting outcome in renal thrombotic microangiopathy: A large cohort study from a single institute in China. ScientificWorldJournal 2014: 680502, 2014
24. Rosove MH: Thrombotic microangiopathies. Semin Arthritis Rheum 43: 797–805, 2014
25. van Timmeren MM, Heeringa P: Pathogenesis of ANCA-associated vasculitis: Recent insights from animal models. Curr Opin Rheumatol 24: 8–14, 2012
26. Xiao H, Schreiber A, Heeringa P, Falk RJ, Jennette JC: Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies. Am J Pathol 170: 52–64, 2007
27. Huugen D, van Esch A, Xiao H, Peutz-Kootstra CJ, BuurmanWA, Tervaert JW, Jennette JC, Heeringa P: Inhibition of complement factor C5 protects against anti-myeloperoxidase antibodymediated glomerulonephritis in mice. Kidney Int 71: 646–654, 2007
28. Schreiber A, Xiao H, Jennette JC, Schneider W, Luft FC, Kettritz R: C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis. J Am Soc Nephrol 20: 289–298, 2009
29. Xing GQ, Chen M, Liu G, Heeringa P, Zhang JJ, Zheng X, Kallenberg G, Zhao MH: Complement activation is involved in renal damage in human antineutrophil cytoplasmic autoantibody associated pauci-immune vasculitis. J Clin Immunol 29: 282–291, 2009
30. Gou SJ, Yuan J, Chen M, Yu F, Zhao MH: Circulating complement activation in patients with anti-neutrophil cytoplasmic antibodyassociated vasculitis. Kidney Int 83: 129–137, 2013
31. Noris M, Remuzzi G: Atypical hemolytic-uremic syndrome. N Engl J Med 361: 1676–1687, 2009
32. Zipfel PF, Heinen S, Skerka C: Thrombotic microangiopathies: New insights and new challenges. Curr Opin Nephrol Hypertens 19: 372–378, 2010
33. George JN, Nester CM: Syndromes of thrombotic microangiopathy. N Engl J Med 371: 1847–1848, 2014
34. Meri S: Complement activation in diseases presenting with thrombotic microangiopathy. Eur J Intern Med 24: 496–502, 2013
35. Xiao H, Dairaghi DJ, Powers JP, Ertl LS, Baumgart T, Wang Y, Seitz LC, Penfold ME, Gan L, Hu P, Lu B, Gerard NP, Gerard C, Schall TJ, Jaen JC, Falk RJ, Jennette JC: C5a receptor (CD88) blockade protects against MPO-ANCA GN. J AmSocNephrol 25: 225–231, 2014
36. ClinicalTrials.gov: A Study to Evaluate the Safety and Efficacy of CCX168 in Subjects With ANCA-Associated Vasculitis, 2014. Available at: http://clinicaltrials.gov/ct2/show/NCT01363388. Accessed September 27, 2014
37. Legendre CM, Licht C, Muus P, Greenbaum LA, Babu S, Bedrosian C, Bingham C, Cohen DJ, Delmas Y, Douglas K, Eitner F, Feldkamp T, Fouque D, Furman RR, Gaber O, Herthelius M, Hourmant M, Karpman D, Lebranchu Y, Mariat C, Menne J, Moulin B, Nurnberger J, Ogawa M, Remuzzi G, Richard T, Sberro-Soussan R, Severino B, Sheerin NS, Trivelli A, Zimmerhackl LB, Goodship T, Loirat C: Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med 368: 2169–2181, 2013
38. Kessenbrock K, Krumbholz M, Schonermarck U, Back W, Gross WL, Werb Z, Grone HJ, Brinkmann V, Jenne DE: Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15: 623–625, 2009
39. Nakazawa D, Shida H, Tomaru U, Yoshida M, Nishio S, Atsumi T, Ishizu A: Enhanced formation and disordered regulation of NETs in myeloperoxidase-ANCA-associated microscopic polyangiitis. J Am Soc Nephrol 25: 990–997, 2014
40. Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, La¨mmle B: Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies. Blood 120: 1157–1164, 2012
41. Ma YC, Zuo L, Chen JH, Luo Q, Yu XQ, Li Y, Xu JS, Huang SM, Wang LN, Huang W, Wang M, Xu GB, Wang HY: Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 17: 2937–2944, 2006