Nephron reconstitution from pluripotent stem cells

Kidney International

Volumn 87, Issue 5, 2015, Pages 894-900

  Taguchi, Atsuhiro ^a   Nishinakamura, Ryuichi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

development; intermediate mesoderm; kidney; origin; regenerative medicine; stem cell

Indexed keywords

WNT PROTEIN;

ARTIFICIAL KIDNEY; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL MATURATION; DEVELOPMENTAL BIOLOGY; ENGRAFTMENT; GLOMERULUS; HUMAN; KIDNEY; KIDNEY DEVELOPMENT; KIDNEY FUNCTION; KIDNEY TUBULE; METANEPHRIC MESENCHYME; NEPHRON; NONHUMAN; PLURIPOTENT STEM CELL; PODOCYTE; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; SIGNAL TRANSDUCTION; THREE DIMENSIONAL IMAGING; URETERIC BUD; ANIMAL; CYTOLOGY; EMBRYOLOGY; PHYSIOLOGY; REGENERATION;

ANIMALS; HUMANS; NEPHRONS; PLURIPOTENT STEM CELLS; REGENERATION;

EID: 84929129197     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2014.358     Document Type: Short Survey

References (44)

1. Murry CE, Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 2008; 132: 661-680.
2. Diep CQ, Ma D, Deo RC et al. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature 2011; 470: 95-100.
3. Singh SR, Liu W, Hou SX. The adult Drosophila malpighian tubules are maintained by multipotent stem cells. Cell Stem Cell 2007; 1: 191-203.
4. Cirio MC, de Groh ED, de Caestecker MP et al. Kidney regeneration: common themes from the embryo to the adult. Pediatr Nephrol 2014; 29: 553-564.
5. Humphreys BD, Lin SL, Kobayashi A et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010; 176: 85-97.
6. Lasagni L, Romagnani P. Glomerular epithelial stem cells: the good, the bad, and the ugly. J Am Soc Nephrol 2010; 21: 1612-1619.
7. Shkreli M, Sarin KY, Pech MF et al. Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Nat Med 2012; 18: 111-119.
8. Osafune K, Takasato M, Kispert A et al. Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development 2006; 133: 151-161.
9. Kobayashi A, Valerius MT, Mugford JW et al. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 2008; 3: 169-181.
10. Ieda M, Fu JD, Delgado-Olguin P et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010; 142: 375-386.
11. Zhou Q, Brown J, Kanarek A et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008; 455: 627-632.
12. Hendry CE, Vanslambrouck JM, Ineson J et al. Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. J Am Soc Nephrol 2013; 24: 1424-1434.
13. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154-156.
14. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
15. Williams LA, Davis-Dusenbery BN, Eggan KC. SnapShot: directed differentiation of pluripotent stem cells. Cell 2012; 149: 1174-1174, e1171.
16. Drawbridge J, Meighan CM, Lumpkins R et al. Pronephric duct extension in amphibian embryos: migration and other mechanisms. Dev Dyn 2003; 226: 1-11.
17. Bouchard M, Souabni A, Mandler M et al. Nephric lineage specification by Pax2 and Pax8. Genes Dev 2002; 16: 2958-2970.
18. Mugford JW, Sipila P, McMahon JA et al. Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol 2008; 324: 88-98.
19. Mae S, Shono A, Shiota F et al. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun 2013; 4: 1367.
20. Xia Y, Nivet E, Sancho-Martinez I et al. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat Cell Biol 2013; 15: 1507-1515.
21. Takasato M, Er PX, Becroft M et al. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat Cell Biol 2014; 16: 118-126.
22. Lam AQ, Freedman BS, Morizane R et al. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol 2013; 25: 1211-1225.
23. Taguchi A, Kaku Y, Ohmori T et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 2013; 14: 53-67.
24. Wilson V, Olivera-Martinez I, Storey KG. Stem cells, signals and vertebrate body axis extension. Development 2009; 136: 1591-1604.
25. Tzouanacou E, Wegener A, Wymeersch FJ et al. Redefining the progression of lineage segregations during mammalian embryogenesis by clonal analysis. Dev Cell 2009; 17: 365-376.
26. Takemoto T, Uchikawa M, Yoshida M et al. Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature 2011; 470: 394-398.
27. Dressler GR. Advances in early kidney specification, development and patterning. Development 2009; 136: 3863-3874.
28. Costantini F, Kopan R. Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell 2010; 18: 698-712.
29. Poladia DP, Kish K, Kutay B et al. Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev Biol 2006; 291: 325-339.
30. Kim D, Dressler GR. Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia. J Am Soc Nephrol 2005; 16: 3527-3534.
31. Moriya N, Uchiyama H, Asashima M. Induction of pronephric tubules by activin and retinoic acid in presumptive ectoderm of Xenopus laevis. Dev Growth Differ 1993; 35: 6.
32. Lengerke C, Schmitt S, Bowman TV et al. BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell 2008; 2: 72-82.
33. Mendjan S, Mascetti VL, Ortmann D et al. NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency. Cell Stem Cell 2014; 15: 310-325.
34. Gouti M, Tsakiridis A, Wymeersch FJ et al. In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity. PLoS Biol 2014; 12: e1001937.
35. Kispert A, Vainio S, McMahon AP. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development 1998; 125: 4225-4234.
36. Li W, Hartwig S, Rosenblum ND. Developmental origins and functions of stromal cells in the normal and diseased mammalian kidney. Dev Dyn 2014; 243: 853-863.
37. Mendelsohn C, Batourina E, Fung S et al. Stromal cells mediate retinoiddependent functions essential for renal development. Development 1999; 126: 1139-1148.
38. Das A, Tanigawa S, Karner CM et al. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol 2013; 15: 1035-1044.
39. Takebe T, Sekine K, Enomura M et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 2013; 499: 481-484.
40. Sackmann EK, Fulton AL, Beebe DJ. The present and future role of microfluidics in biomedical research. Nature 2014; 507: 181-189.
41. Badylak SF, Weiss DJ, Caplan A et al. Engineered whole organs and complex tissues. Lancet 2012; 379: 943-952.
42. Song JJ, Guyette JP, Gilpin SE et al. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med 2013; 19: 646-651.
43. Barak H, Huh SH, Chen S et al. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell 2012; 22: 1191-1207.
44. Schedl A. Renal abnormalities and their developmental origin. Nat Rev Genet 2007; 8: 791-802.