Recycled IL-7 can be delivered to neighboring T cells

Journal of Immunology

Volumn 194, Issue 10, 2015, Pages 4698-4704

  Bazdar, Douglas A ^a   Kalinowska, Magdalena ^b   Panigrahi, Soumya ^a   Sieg, Scott F ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; RAB11 PROTEIN; RECOMBINANT INTERLEUKIN 7; STAT5 PROTEIN; IL7 PROTEIN, HUMAN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO; ENDOCYTOSIS; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-7; LYMPHOCYTE ACTIVATION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84929121169     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400560     Document Type: Article

References (26)

1. Giliani, S., L. Mori, G. de Saint Basile, F. Le Deist, C. Rodriguez-Perez, C. Forino, E. Mazzolari, S. Dupuis, R. Elhasid, A. Kessel, et al. 2005. Interleukin-7 receptor alpha (IL-7Ralpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients. Immunol. Rev. 203: 110-126.
2. Peschon, J. J., P. J. Morrissey, K. H. Grabstein, F. J. Ramsdell, E. Maraskovsky, B. C. Gliniak, L. S. Park, S. F. Ziegler, D. E. Williams, C. B. Ware, et al. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180: 1955-1960.
3. von Freeden-Jeffry, U., P. Vieira, L. A. Lucian, T. McNeil, S. E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181: 1519-1526.
4. Kondrack, R. M., J. Harbertson, J. T. Tan, M. E. McBreen, C. D. Surh, and L. M. Bradley. 2003. Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med. 198: 1797-1806.
5. Tan, J. T., E. Dudl, E. LeRoy, R. Murray, J. Sprent, K. I. Weinberg, and C. D. Surh. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc. Natl. Acad. Sci. USA 98: 8732-8737.
6. Levy, Y., C. Lacabaratz, L. Weiss, J. P. Viard, C. Goujard, J. D. Lelièvre, F. Boué, J. M. Molina, C. Rouzioux, V. Avettand-Fénoêl, et al. 2009. Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J. Clin. Invest. 119: 997-1007.
7. Lévy, Y., I. Sereti, G. Tambussi, J. P. Routy, J. D. Lelièvre, J. F. Delfraissy, J. M. Molina, M. Fischl, C. Goujard, B. Rodriguez, et al. 2012. Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIVinfected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study. Clin. Infect. Dis. 55: 291-300.
8. Sereti, I., R. M. Dunham, J. Spritzler, E. Aga, M. A. Proschan, K. Medvik, C. A. Battaglia, A. L. Landay, S. Pahwa, M. A. Fischl, et al ACTG 5214 Study Team. 2009. IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood 113: 6304-6314.
9. Sportès, C., F. T. Hakim, S. A. Memon, H. Zhang, K. S. Chua, M. R. Brown, T. A. Fleisher, M. C. Krumlauf, R. R. Babb, C. K. Chow, et al. 2008. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J. Exp. Med. 205: 1701-1714.
10. Park, J. H., Q. Yu, B. Erman, J. S. Appelbaum, D. Montoya-Durango, H. L. Grimes, and A. Singer. 2004. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7- dependent T cell survival. Immunity 21: 289-302.
11. Mazzucchelli, R., and S. K. Durum. 2007. Interleukin-7 receptor expression: intelligent design. Nat. Rev. Immunol. 7: 144-154.
12. Dubois, S., J. Mariner, T. A. Waldmann, and Y. Tagaya. 2002. IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 17: 537-547.
13. Wuest, S. C., J. H. Edwan, J. F. Martin, S. Han, J. S. Perry, C. M. Cartagena, E. Matsuura, D. Maric, T. A. Waldmann, and B. Bielekova. 2011. A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy. Nat. Med. 17: 604-609.
14. Taga, T., M. Hibi, Y. Hirata, K. Yamasaki, K. Yasukawa, T. Matsuda, T. Hirano, and T. Kishimoto. 1989. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58: 573-581.
15. Bazdar, D. A., M. Kalinowska, and S. F. Sieg. 2009. Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging. J. Infect. Dis. 199: 1019-1028.
16. Kalinowska, M., D. A. Bazdar, M. M. Lederman, N. Funderburg, and S. F. Sieg. 2013. Decreased IL-7 responsiveness is related to oxidative stress in HIV disease. PLoS ONE 8: e58764. Available at: http://journals.plos.org/plosone/article? id510.1371/journal.pone.0058764.
17. Henriques, C. M., J. Rino, R. J. Nibbs, G. J. Graham, and J. T. Barata. 2010. IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells. Blood 115: 3269-3277.
18. Gibson, A. E., R. J. Noel, J. T. Herlihy, and W. F. Ward. 1989. Phenylarsine oxide inhibition of endocytosis: effects on asialofetuin internalization. Am. J. Physiol. 257: C182-C184.
19. Hertel, C., S. J. Coulter, and J. P. Perkins. 1985. A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide. J. Biol. Chem. 260: 12547-12553.
20. Green, E. G., E. Ramm, N. M. Riley, D. J. Spiro, J. R. Goldenring, and M. Wessling-Resnick. 1997. Rab11 is associated with transferrin-containing recycling compartments in K562 cells. Biochem. Biophys. Res. Commun. 239: 612-616.
21. Horgan, C. P., S. R. Hanscom, R. S. Jolly, C. E. Futter, and M. W. McCaffrey. 2010. Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex. Biochem. Biophys. Res. Commun. 394: 387-392.
22. Schlierf, B., G. H. Fey, J. Hauber, G. M. Hocke, and O. Rosorius. 2000. Rab11b is essential for recycling of transferrin to the plasma membrane. Exp. Cell Res. 259: 257-265.
23. Trischler, M., W. Stoorvogel, and O. Ullrich. 1999. Biochemical analysis of distinct Rab5- and Rab11-positive endosomes along the transferrin pathway. J. Cell Sci. 112: 4773-4783.
24. Ullrich, O., S. Reinsch, S. Urbé, M. Zerial, and R. G. Parton. 1996. Rab11 regulates recycling through the pericentriolar recycling endosome. J. Cell Biol. 135: 913-924.
25. Borghesi, L. A., Y. Yamashita, and P. W. Kincade. 1999. Heparan sulfate proteoglycans mediate interleukin-7-dependent B lymphopoiesis. Blood 93: 140-148.
26. Clarke, D., O. Katoh, R. V. Gibbs, S. D. Griffiths, and M. Y. Gordon. 1995. Interaction of interleukin 7 (IL-7) with glycosaminoglycans and its biological relevance. Cytokine 7: 325-330.