Cancer-associated oxidase ERO1-α regulates the expression of MHC class I molecule via oxidative folding

Journal of Immunology

Volumn 194, Issue 10, 2015, Pages 4988-4996

  Kukita, Kazuharu ^a   Tamura, Yasuaki ^a   Tanaka, Tsutomu ^a   Kajiwara, Toshimitsu ^a   Kutomi, Goro ^a   Saito, Keita ^a   Okuya, Koichi ^a   Takaya, Akari ^a   Kanaseki, Takayuki ^a   Tsukahara, Tomohide ^a   Hirohashi, Yoshihiko ^a   Torigoe, Toshihiko ^a   Furuhata, Tomohisa ^a   Hirata, Koichi ^a   Sato, Noriyuki ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; ERO1 ALPHA PROTEIN; GLYCOPROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN DISULFIDE ISOMERASE; UNCLASSIFIED DRUG; ERO1L PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; MEMBRANE PROTEIN; OXIDOREDUCTASE;

ANTIGEN PRESENTATION; ARTICLE; CANCER CELL LINE; CD8+ T LYMPHOCYTE; COLON CANCER; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; OXIDATION; OXIDATION REDUCTION STATE; OXIDATIVE FOLDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; BIOSYNTHESIS; COLON TUMOR; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IMMUNOPRECIPITATION; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANTIGEN PRESENTATION; BLOTTING, WESTERN; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; COLONIC NEOPLASMS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEMBRANE GLYCOPROTEINS; OXIDATION-REDUCTION; OXIDOREDUCTASES; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84929104778     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1303228     Document Type: Article

References (27)

1. Diedrich, G., N. Bangia, M. Pan, and P. Cresswell. 2001. A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum. J. Immunol. 166: 1703-1709.
2. Wearsch, P. A., and P. Cresswell. 2008. The quality control of MHC class I peptide loading. Curr. Opin. Cell Biol. 20: 624-631.
3. Kienast, A., M. Preuss, M. Winkler, and T. P. Dick. 2007. Redox regulation of peptide receptivity of major histocompatibility complex class I molecules by ERp57 and tapasin. Nat. Immunol. 8: 864-872.
4. Park, B., S. Lee, E. Kim, K. Cho, S. R. Riddell, S. Cho, and K. Ahn. 2006. Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. Cell 127: 369-382.
5. Kang, K., B. Park, C. Oh, K. Cho, and K. Ahn. 2009. A role for protein disulfide isomerase in the early folding and assembly of MHC class I molecules. Antioxid. Redox Signal. 11: 2553-2561.
6. Sevier, C. S., H. Qu, N. Heldman, E. Gross, D. Fass, and C. A. Kaiser. 2007. Modulation of cellular disulfide-bond formation and the ER redox environment by feedback regulation of Ero1. Cell 129: 333-344.
7. Benham, A. M., A. Cabibbo, A. Fassio, N. Bulleid, R. Sitia, and I. Braakman. 2000. The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lα. EMBO J. 19: 4493-4502.
8. Cabibbo, A., M. Pagani, M. Fabbri, M. Rocchi, M. R. Farmery, N. J. Bulleid, and R. Sitia. 2000. ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J. Biol. Chem. 275: 4827-4833.
9. Frand, A. R., and C. A. Kaiser. 1999. Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum. Mol. Cell 4: 469-477.
10. Kutomi, G., Y. Tamura, T. Tanaka, T. Kajiwara, K. Kukita, T. Ohmura, H. Shima, T. Takamaru, F. Satomi, Y. Suzuki, et al. 2013. Human endoplasmic reticulum oxidoreductin 1-α is a novel predictor for poor prognosis of breast cancer. Cancer Sci. 104: 1091-1096.
11. Idenoue, S., Y. Hirohashi, T. Torigoe, Y. Sato, Y. Tamura, H. Hariu, M. Yamamoto, T. Kurotaki, T. Tsuruma, H. Asanuma, et al. 2005. A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins. Clin. Cancer Res. 11: 1474-1482.
12. Torigoe, T., H. Asanuma, E. Nakazawa, Y. Tamura, Y. Hirohashi, E. Yamamoto, T. Kanaseki, T. Hasegawa, and N. Sato. 2012. Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: unusually high frequency of down-regulation in breast cancer tissues. Pathol. Int. 62: 303-308.
13. Rufer, E., R. M. Leonhardt, and M. R. Knittler. 2007. Molecular architecture of the TAP-associated MHC class I peptide-loading complex. J. Immunol. 179: 5717-5727.
14. Mezghrani, A., A. Fassio, A. Benham, T. Simmen, I. Braakman, and R. Sitia. 2001. Manipulation of oxidative protein folding and PDI redox state in mammalian cells. EMBO J. 20: 6288-6296.
15. Inaba, K., S. Masui, H. Iida, S. Vavassori, R. Sitia, and M. Suzuki. 2010. Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI. EMBO J. 29: 3330-3343.
16. Zito, E., E. P. Melo, Y. Yang, Å. Wahlander, T. A. Neubert, and D. Ron. 2010. Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Mol. Cell 40: 787-797.
17. Tavender, T. J., J. J. Springate, and N. J. Bulleid. 2010. Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum. EMBO J. 29: 4185-4197.
18. Li, W., S. Schulman, R. J. Dutton, D. Boyd, J. Beckwith, and T. A. Rapoport. 2010. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature 463: 507-512.
19. Kodali, V. K., and C. Thorpe. 2010. Oxidative protein folding and the quiescin-sulfhydryl oxidase family of flavoproteins. Antioxid. Redox Signal. 13: 1217-1230.
20. Ghosh, S., A. Paul, and E. Sen. 2013. Tumor necrosis factor α-induced hypoxia-inducible factor 1α-β-catenin axis regulates major histocompatibility complex class I gene activation through chromatin remodeling. Mol. Cell. Biol. 33: 2718-2731.
21. Masui, S., S. Vavassori, C. Fagioli, R. Sitia, and K. Inaba. 2011. Molecular bases of cyclic and specific disulfide interchange between human Ero1α protein and protein-disulfide isomerase (PDI). J. Biol. Chem. 286: 16261-16271.
22. Baker, K. M., S. Chakravarthi, K. P. Langton, A. M. Sheppard, H. Lu, and N. J. Bulleid. 2008. Low reduction potential of Ero1α regulatory disulphides ensures tight control of substrate oxidation. EMBO J. 27: 2988-2997.
23. Wang, L., S. J. Li, A. Sidhu, L. Zhu, Y. Liang, R. B. Freedman, and C. C. Wang. 2009. Reconstitution of human Ero1-Lα/protein-disulfide isomerase oxidative folding pathway in vitro. Position-dependent differences in role between the a and a' domains of protein-disulfide isomerase. J. Biol. Chem. 284: 199-206.
24. Nössner, E., and P. Parham. 1995. Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules. J. Exp. Med. 181: 327-337.
25. Tsukahara, T., S. Kawaguchi, T. Torigoe, H. Asanuma, E. Nakazawa, K. Shimozawa, Y. Nabeta, S. Kimura, M. Kaya, S. Nagoya, et al. 2006. Prognostic significance of HLA class I expression in osteosarcoma defined by antipan HLA class I monoclonal antibody, EMR8-5. Cancer Sci. 97: 1374-1380.
26. Turcotte, S., S. C. Katz, J. Shia, W. R. Jarnagin, T. P. Kingham, P. J. Allen, Y. Fong, M. I. D'Angelica, and R. P. DeMatteo. 2014. Tumor MHC class I expression improves the prognostic value of T-cell density in resected colorectal liver metastases. Cancer Immunol. Res. 2: 530-537.
27. Reimers, M. S., C. C. Engels, H. Putter, H. Morreau, G. J. Liefers, C. J. van de Velde, and P. J. Kuppen. 2014. Prognostic value of HLA class I, HLA-E, HLA-G and Tregs in rectal cancer: a retrospective cohort study. BMC Cancer 14: 486.