-
1
-
-
40949132851
-
The vitamin K cycle
-
Oldenburg, J., Marinova, M., Muller-Reible, C. & Watzka, M. The vitamin K cycle. Vitam. Horm. 78, 35-62 (2008).
-
(2008)
Vitam. Horm.
, vol.78
, pp. 35-62
-
-
Oldenburg, J.1
Marinova, M.2
Muller-Reible, C.3
Watzka, M.4
-
2
-
-
40949129912
-
Structure and function of vitamin K epoxide reductase
-
Tie, J. K. & Stafford, D. W. Structure and function of vitamin K epoxide reductase. Vitam. Horm. 78, 103-130 (2008).
-
(2008)
Vitam. Horm.
, vol.78
, pp. 103-130
-
-
Tie, J.K.1
Stafford, D.W.2
-
3
-
-
0017620768
-
Vitamin K-dependent formation of c-carboxyglutamic acid
-
Stenflo, J. & Suttie, J. W. Vitamin K-dependent formation of c-carboxyglutamic acid. Annu. Rev. Biochem. 46, 157-172 (1977).
-
(1977)
Annu. Rev. Biochem.
, vol.46
, pp. 157-172
-
-
Stenflo, J.1
Suttie, J.W.2
-
4
-
-
0033559305
-
Vitamin K-dependent biosynthesis of c-carboxyglutamic acid
-
Furie, B., Bouchard, B. A. & Furie, B. C. Vitamin K-dependent biosynthesis of c-carboxyglutamic acid. Blood 93, 1798-1808 (1999).
-
(1999)
Blood
, vol.93
, pp. 1798-1808
-
-
Furie, B.1
Bouchard, B.A.2
Furie, B.C.3
-
5
-
-
34047258016
-
Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction
-
Wajih, N., Hutson, S. M. & Wallin, R. Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction. J. Biol. Chem. 282, 2626-2635 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 2626-2635
-
-
Wajih, N.1
Hutson, S.M.2
Wallin, R.3
-
6
-
-
0026547487
-
Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin system. Strong synergistic effects with protein disulphide-isomerase
-
Soute, B. A., Groenen-van Dooren, M. M., Holmgren, A., Lundstrom, J. & Vermeer, C. Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin system. Strong synergistic effects with protein disulphide-isomerase. Biochem. J. 281, 255-259 (1992).
-
(1992)
Biochem. J.
, vol.281
, pp. 255-259
-
-
Soute, B.A.1
Groenen-Van Dooren, M.M.2
Holmgren, A.3
Lundstrom, J.4
Vermeer, C.5
-
7
-
-
33845878853
-
Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2
-
Chu, P. H., Huang, T. Y., Williams, J. & Stafford, D. W. Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2. Proc. Natl Acad. Sci. USA 103, 19308-19313 (2006)
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 19308-19313
-
-
Chu, P.H.1
Huang, T.Y.2
Williams, J.3
Stafford, D.W.4
-
8
-
-
60849097257
-
Estimationof thewarfarin dose with clinical and pharmacogenetic data
-
The International Warfarin Pharmacogenetics Consortium
-
The International Warfarin Pharmacogenetics Consortium. Estimationof thewarfarin dose with clinical and pharmacogenetic data. N. Engl. J. Med. 360, 753-764 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 753-764
-
-
-
9
-
-
10744228888
-
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
-
Rost, S. et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 427, 537-541 (2004).
-
(2004)
Nature
, vol.427
, pp. 537-541
-
-
Rost, S.1
-
10
-
-
3242786500
-
Vitamin K epoxide reductase: Homology, active site and catalytic mechanism
-
Goodstadt, L. & Ponting, C. P. Vitamin K epoxide reductase: homology, active site and catalytic mechanism. Trends Biochem. Sci. 29, 289-292 (2004).
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 289-292
-
-
Goodstadt, L.1
Ponting, C.P.2
-
11
-
-
47049096139
-
Identification of an atypical membrane protein involved in the formation of protein disulfide bonds in oxygenic photosynthetic organisms
-
Singh, A. K., Bhattacharyya-Pakrasi, M. & Pakrasi, H. B. Identification of an atypical membrane protein involved in the formation of protein disulfide bonds in oxygenic photosynthetic organisms. J. Biol. Chem. 283, 15762-15770 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 15762-15770
-
-
Singh, A.K.1
Bhattacharyya-Pakrasi, M.2
Pakrasi, H.B.3
-
12
-
-
50149109183
-
Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation
-
Dutton, R. J., Boyd, D., Berkmen, M. & Beckwith, J. Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation. Proc. Natl Acad. Sci. USA 105, 11933-11938 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 11933-11938
-
-
Dutton, R.J.1
Boyd, D.2
Berkmen, M.3
Beckwith, J.4
-
13
-
-
1342304093
-
DsbB elicits a red-shift of bound ubiquinone during the catalysis of DsbA oxidation
-
Inaba, K. et al. DsbB elicits a red-shift of bound ubiquinone during the catalysis of DsbA oxidation. J. Biol. Chem. 279, 6761-6768 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 6761-6768
-
-
Inaba, K.1
-
14
-
-
33750813327
-
Crystal structure of the DsbB-DsbA complex reveals a mechanism of disulfide bond generation
-
Inaba, K. et al. Crystal structure of the DsbB-DsbA complex reveals a mechanism of disulfide bond generation. Cell 127, 789-801 (2006).
-
(2006)
Cell
, vol.127
, pp. 789-801
-
-
Inaba, K.1
-
15
-
-
76249133943
-
Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin
-
doi:10.1073/pnas.0912952107 15 December
-
Dutton, R. J. et al. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc. Natl Acad. Sci. USA advance online publication, doi:10.1073/pnas.0912952107 (15 December 2009).
-
(2009)
Proc. Natl Acad. Sci. USA Advance Online Publication
-
-
Dutton, R.J.1
-
16
-
-
18144423143
-
Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation
-
Tie, J. K., Nicchitta, C., von Heijne, G. & Stafford, D. W. Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/ cotranslocation. J. Biol. Chem. 280, 16410-16416 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16410-16416
-
-
Tie, J.K.1
Nicchitta, C.2
Von Heijne, G.3
Stafford, D.W.4
-
17
-
-
61449103718
-
Novel mutations in the VKORC1 gene of wild rats and mice-a response to 50 years of selection pressure by warfarin?
-
Rost, S. et al. Novel mutations in the VKORC1 gene of wild rats and mice-a response to 50 years of selection pressure by warfarin? BMC Genet. 10, 4 (2009).
-
(2009)
BMC Genet.
, vol.10
, pp. 4
-
-
Rost, S.1
-
18
-
-
25444450735
-
The genetic basis of resistance to anticoagulants in rodents
-
Pelz, H. J. et al. The genetic basis of resistance to anticoagulants in rodents. Genetics 170, 1839-1847 (2005).
-
(2005)
Genetics
, vol.170
, pp. 1839-1847
-
-
Pelz, H.J.1
-
19
-
-
27144553194
-
Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: Evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin
-
Rost, S. et al. Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin. Thromb. Haemost. 94, 780-786 (2005).
-
(2005)
Thromb. Haemost.
, vol.94
, pp. 780-786
-
-
Rost, S.1
-
20
-
-
33845545299
-
A new vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with decreased stability of CYP2C9 enzyme
-
D'Ambrosio, R. L., D'Andrea, G., Cafolla, A., Faillace, F. & Margaglione, M. A new vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with decreased stability of CYP2C9 enzyme. J. Thromb. Haemost. 5, 191-193 (2007).
-
(2007)
J. Thromb. Haemost.
, vol.5
, pp. 191-193
-
-
D'Ambrosio, R.L.1
D'Andrea, G.2
Cafolla, A.3
Faillace, F.4
Margaglione, M.5
-
21
-
-
0019782217
-
Chemical model studies for the mechanism of vitamin K epoxide reductase
-
Silverman, R. B. Chemical model studies for the mechanism of vitamin K epoxide reductase. J. Am. Chem. Soc. 103, 5939-5941 (1981).
-
(1981)
J. Am. Chem. Soc.
, vol.103
, pp. 5939-5941
-
-
Silverman, R.B.1
-
22
-
-
2542475140
-
Structure of Ero1p, source of disulfide bonds for oxidative protein folding in the cell
-
Gross, E., Kastner, D. B., Kaiser, C. A. & Fass, D. Structure of Ero1p, source of disulfide bonds for oxidative protein folding in the cell. Cell 117, 601-610 (2004).
-
(2004)
Cell
, vol.117
, pp. 601-610
-
-
Gross, E.1
Kastner, D.B.2
Kaiser, C.A.3
Fass, D.4
-
23
-
-
0036142325
-
A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p
-
Gross, E., Sevier, C. S., Vala, A., Kaiser, C. A. & Fass, D. A new FAD-binding fold and intersubunit disulfide shuttle in the thiol oxidase Erv2p. Nature Struct. Biol. 9, 61-67 (2002).
-
(2002)
Nature Struct. Biol.
, vol.9
, pp. 61-67
-
-
Gross, E.1
Sevier, C.S.2
Vala, A.3
Kaiser, C.A.4
Fass, D.5
-
24
-
-
33846919393
-
Synthesis and structure-activity relationships of novel warfarin derivatives
-
Gebauer, M. Synthesis and structure-activity relationships of novel warfarin derivatives. Bioorg. Med. Chem. 15, 2414-2420 (2007).
-
(2007)
Bioorg. Med. Chem.
, vol.15
, pp. 2414-2420
-
-
Gebauer, M.1
-
25
-
-
34250796202
-
The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines
-
Jin, D. Y., Tie, J. K. & Stafford, D. W. The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines. Biochemistry 46, 7279-7283 (2007).
-
(2007)
Biochemistry
, vol.46
, pp. 7279-7283
-
-
Jin, D.Y.1
Tie, J.K.2
Stafford, D.W.3
-
26
-
-
0027475212
-
A pathway for disulfide bond formation in vivo
-
Bardwell, J. C. et al. A pathway for disulfide bond formation in vivo. Proc. Natl Acad. Sci. USA 90, 1038-1042 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 1038-1042
-
-
Bardwell, J.C.1
-
27
-
-
0032562757
-
Reconstitution of a protein disulfide catalytic system
-
Bader, M., Muse, W., Zander, T. & Bardwell, J. Reconstitution of a protein disulfide catalytic system. J. Biol. Chem. 273, 10302-10307 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10302-10307
-
-
Bader, M.1
Muse, W.2
Zander, T.3
Bardwell, J.4
-
28
-
-
0029161150
-
DsbA-DsbB interaction through their active site cysteines. Evidence from an odd cysteine mutant of DsbA
-
Kishigami, S., Kanaya, E., Kikuchi, M. & Ito, K. DsbA-DsbB interaction through their active site cysteines. Evidence from an odd cysteine mutant of DsbA. J. Biol. Chem. 270, 17072-17074 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 17072-17074
-
-
Kishigami, S.1
Kanaya, E.2
Kikuchi, M.3
Ito, K.4
-
29
-
-
54549124476
-
Preparation and structure of the charge-transfer intermediate of the transmembrane redox catalyst DsbB
-
Malojcic, G., Owen, R. L., Grimshaw, J. P. & Glockshuber, R. Preparation and structure of the charge-transfer intermediate of the transmembrane redox catalyst DsbB. FEBS Lett. 582, 3301-3307 (2008).
-
(2008)
FEBS Lett.
, vol.582
, pp. 3301-3307
-
-
Malojcic, G.1
Owen, R.L.2
Grimshaw, J.P.3
Glockshuber, R.4
-
30
-
-
52049098074
-
NMR solution structure of the integral membrane enzyme DsbB: Functional insights into DsbB-catalyzed disulfide bond formation
-
Zhou, Y. et al. NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Mol. Cell 31, 896-908 (2008).
-
(2008)
Mol. Cell
, vol.31
, pp. 896-908
-
-
Zhou, Y.1
-
31
-
-
62649151322
-
Dynamic nature of disulphide bond formation catalysts revealed by crystal structures of DsbB
-
Inaba, K. et al. Dynamic nature of disulphide bond formation catalysts revealed by crystal structures of DsbB. EMBO J. 28, 779-791 (2009).
-
(2009)
EMBO J.
, vol.28
, pp. 779-791
-
-
Inaba, K.1
-
32
-
-
0345133346
-
Disulfide bond formation involves a quinhydrone-type charge-transfer complex
-
Regeimbal, J. et al. Disulfide bond formation involves a quinhydrone-type charge-transfer complex. Proc. Natl Acad. Sci. USA 100, 13779-13784 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 13779-13784
-
-
Regeimbal, J.1
-
33
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
35
-
-
0002473587
-
Phase combination and cross validation in iterated density-modification calculations
-
Cowtan, K. D. & Main, P. Phase combination and cross validation in iterated density-modification calculations. Acta Crystallogr. D 52, 43-48 (1996).
-
(1996)
Acta Crystallogr. D
, vol.52
, pp. 43-48
-
-
Cowtan, K.D.1
Main, P.2
-
36
-
-
0030817618
-
Combining constraints for electron-density modification
-
Zhang, K. Y., Cowtan, K. & Main, P. Combining constraints for electron-density modification. Methods Enzymol. 277, 53-64 (1997).
-
(1997)
Methods Enzymol.
, vol.277
, pp. 53-64
-
-
Zhang, K.Y.1
Cowtan, K.2
Main, P.3
-
37
-
-
37549039510
-
A short history of SHELX
-
Sheldrick, G. M. A short history of SHELX. Acta Crystallogr. A 64, 112-122 (2008).
-
(2008)
Acta Crystallogr.
, vol.64
, pp. 112-122
-
-
Sheldrick, G.M.1
-
38
-
-
50249136103
-
Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7
-
Langer, G., Cohen, S. X., Lamzin, V. S. & Perrakis, A. Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7. Nature Protocols 3, 1171-1179 (2008).
-
(2008)
Nature Protocols
, vol.3
, pp. 1171-1179
-
-
Langer, G.1
Cohen, S.X.2
Lamzin, V.S.3
Perrakis, A.4
-
39
-
-
84889120137
-
Improved methods for building protein models in electron density maps and the location of errors in these models
-
Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119 (1991).
-
(1991)
Acta Crystallogr.
, vol.47
, pp. 110-119
-
-
Jones, T.A.1
Zou, J.Y.2
Cowan, S.W.3
Kjeldgaard, M.4
-
40
-
-
13244281317
-
Coot: Model-building tools for molecular graphics
-
Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D 60, 2126-2132 (2004).
-
(2004)
Acta Crystallogr. D
, vol.60
, pp. 2126-2132
-
-
Emsley, P.1
Cowtan, K.2
-
41
-
-
0035182073
-
Use of TLS parameters to model anisotropic displacements in macromolecular refinement
-
Winn, M. D., Isupov, M. N. & Murshudov, G. N. Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallogr. D 57, 122-133 (2001).
-
(2001)
Acta Crystallogr. D
, vol.57
, pp. 122-133
-
-
Winn, M.D.1
Isupov, M.N.2
Murshudov, G.N.3
-
42
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
Murshudov, G. N., Vagin, A. A. & Dodson, E. J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D 53, 240-255 (1997).
-
(1997)
Acta Crystallogr. D
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
43
-
-
0034711439
-
Biochemical basis of oxidative protein folding in the endoplasmic reticulum
-
Tu, B. P., Ho-Schleyer, S. C., Travers, K. J. & Weissman, J. S. Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science 290, 1571-1574 (2000).
-
(2000)
Science
, vol.290
, pp. 1571-1574
-
-
Tu, B.P.1
Ho-Schleyer, S.C.2
Travers, K.J.3
Weissman, J.S.4
|