Lacosamide reduces HDAC levels in the brain and improves memory: Potential for treatment of Alzheimer's disease

Pharmacology Biochemistry and Behavior

Volumn 134, Issue , 2015, Pages 65-69

  Bang, Shraddha R ^a   Ambavade, Shirishkumar D ^a   Jagdale, Priti G ^a   Adkar, Prafulla P ^a   Waghmare, Arun B ^b   Ambavade, Prashant D ^b  

^a Jaywantrao Sawant College of Pharmacy and Research   (India)

^b Haffkine Bio Pharmaceutical Corporation Ltd   (India)

Author keywords

Acetylcholinesterase; HDAC; Lacosamide; Object recognition; Radial arm maze

Indexed keywords

ACETYLCHOLINESTERASE; HARKOSERIDE; HISTONE DEACETYLASE 1; PIRACETAM; ACETAMIDE DERIVATIVE; HISTONE DEACETYLASE; LACOSAMIDE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ELEVATED PLUS MAZE TEST; MEMORY CONSOLIDATION; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PRIORITY JOURNAL; RADIAL ARM MAZE TEST; RAT; SCOPOLAMINE-INDUCED AMNESIA; TREATMENT OUTCOME; TREATMENT RESPONSE; ANIMAL; BRAIN; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; MEMORY; METABOLISM; MOUSE; WISTAR RAT;

ANIMALIA;

ACETAMIDES; ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTONE DEACETYLASES; MEMORY; MICE; RATS; RATS, WISTAR;

EID: 84929095548     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2015.04.011     Document Type: Article

References (35)

1. T. Abel, and R.S. Zukin Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders Curr Opin Pharmacol 8 2008 57 64
2. I. Akirav, and M. Maroun Ventromedial prefrontal cortex is obligatory for consolidation and reconsolidation of object recognition memory Cereb Cortex 16 2006 1759 1765
3. G.R. Barker, Z.I. Bashir, M.W. Brown, and E.C. Warburton A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory Learn Mem 13 2006 178 186
4. E. Ben-Menachem Lacosamide: an investigational drug for adjunctive treatment of partial-onset seizures Drugs Today 44 2008 35 40
5. E. Ben-Menachem, V. Biton, D. Jatuzis, B. Abou-Khalil, P. Doty, and G.D. Rudd Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures Epilepsia 48 2007 1308 1317
6. M. Bialer Chemical properties of antiepileptic drugs (AEDs) Adv Drug Deliv Rev 64 2012 887 895
7. D.J. Cada, T.L. Levien, and D.E. Baker Lacosamide Hosp Pharm 44 2009 497 508
8. J. Chen, Y. Long, M. Han, T. Wang, Q. Chen, and R. Wang Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice Pharmacol Biochem Behav 90 2008 441 446
9. S.D. Chintawar, R.S. Somani, V.S. Kasture, and S.B. Kasture Nootropic activity of Albizzialebbeck in mice J Ethnopharmacol 81 2002 299 305
10. C. Crosby, D.J. Culley, M.G. Baxter, R. Yukhananov, and G. Crosby Spatial memory performance 2 weeks after general anesthesia in adult rats Anesth Analg 101 2005 1389 1392
11. H.P. Davis, J. Tribuna, W.A. Pulsinelli, and B.T. Volpe Reference and working memory of rats following hippocampal damage induced by transient forebrain ischemia Physiol Behav 37 1986 387 392
12. K. Duff, and F. Suleman Transgenic mouse models of Alzheimer's disease: how useful have they been for therapeutic development? Brief Funct Genomic Proteomic 3 2004 47 59
13. A. Ennaceur, and K. Meliani A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. nonspatial working memory Behav Brain Res 51 1992 83 92
14. A.C. Errington, L. Coyne, T. Stohr, N. Selve, and G. Lees Seeking a mechanism of action for the novel anticonvulsant lacosamide Neuropharmacology 50 2006 1016 1029
15. A. Errington, T. Stohr, C. Heers, and G. Lees The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels Mol Pharmacol 73 2008 157 169
16. A. Fischer, F. Sananbenesi, A. Mungenast, and L.H. Tsai Targeting the correct HDAC(s) to treat cognitive disorders Trends Pharmacol Sci 31 2010 605 617
17. J.M. Freitag, B. Beyreuther, C. Heers, and T. Stoehr Lacosamide modulates collapsing response mediator protein 2 (CRMP-2) Epilepsia 48 2007 320
18. A. Gupta, Jalhan S. Hemraj, A. Jindal, and N. Upmanyu Various animal models to check learning and memory - a review Int J Pharm Pharm Sci 4 2012 91 95
19. P. Halasz, R. Kalviainen, M. Mazurkiewicz-Beldzinska, F. Rosenow, P. Doty, and T. Sullivan Lacosamide: efficacy and safety as oral therapy in adults with partial seizures Epilepsia 47 2006 3
20. C. Heers, G. Lees, A. Errington, and T. Stoehr Lacosamide selectively enhances sodium channel slow inactivation Epilepsia 48 2007 320
21. L.E. Jarrard Selective hippocampal lesions: differential effects on performance by rats of spatial task with preoperative versus postoperative training J Comp Physiol Psychol 92 1978 1119 1127
22. M. Kilgore, C.A. Miller, D.M. Fass, K.M. Hennig, S.J. Haggarty, J.D. Sweatt, and G. Rumbaugh Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease Neuropsychopharmacology 35 2010 870 880
23. A.P. Kozikowski, Y. Chen, T. Subhasish, N.E. Lewin, P.M. Blumberg, and Z. Zhong et al. Searching for disease modifiers - PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that reduces production while blocking oxidative stress Chem Med Chem 4 2009 1095 1105
24. S.H. Kwon, H.C. Kim, S.Y. Lee, and C.G. Jang Loganin improves learning and memory impairments induced by scopolamine in mice Eur J Pharmacol 619 2009 44 49
25. T.H. Moran, G.T. Capone, S. Knipp, M.T. Davisson, R.H. Reeves, and J.D. Gearhart The effects of piracetam on cognitive performance in a mouse model of Down's syndrome Physiol Behav 77 2002 403 409
26. M. Ohno, T. Yamamoto, and S. Watanabe Effects of intrahippocampal injections of N-methyl-d-aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway task J Pharmacol Exp Ther 263 1992 943 950
27. M. Ohno, T. Yamamoto, and S. Watanabe Intrahippocampal injections of benzodiazepine and muscimol impair working memory but not reference memory of rats in the three panel runway task Eur J Pharmacol 219 1992 245 251
28. M. Ohno, T. Yamamoto, and S. Watanabe Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats Pharmacol Biochem Behav 45 1993 89 93
29. J.M. Rubio-Perez, and J.M. Morillas-Ruiz A review: inflammatory process in Alzheimer's disease, role of cytokines Sci World J 2012 2012 756357
30. The Hindu Alzheimer's will be on the rise in India. Online edition of India's National Newspaper Thursday http://www.hindu.com/seta/2011/04/21/ stories/2011042155291700.htm 2011 (Apr 21)
31. The World health report Mental health: new understanding, new hope 2001 World Health Organization Geneva, Switzerland 1 178 (http://www.who.int/whr/2001/-en/whr01-en.pdf?ua=1)
32. O.A. Timofeeva, and E.D. Levin Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine Pharmacol Biochem Behav 90 2008 372 381
33. H.G. Vogel Drug discovery and evaluation: pharmacological assays, New York 3rd ed. Vol 1 2007 626
34. A. Wimo, L. Jonsson, and B. Winblad An estimate of the worldwide prevalence and direct costs of dementia in 2003 Dement Geriatr Cogn Disord 21 2006 175 181
35. K. Xu, X.L. Dai, H.C. Huang, and Z.F. Jiang Targeting HDACs: a promising therapy for Alzheimer's disease Oxid Med Cell Longev 2011 2011 143269