A direct GABAergic output from the basal ganglia to frontal cortex

Nature

Volumn 521, Issue 7550, 2015, Pages 85-89

  Saunders, Arpiar ^a   Oldenburg, Ian A ^a   Berezovskii, Vladimir K ^a   Johnson, Caroline A ^b   Kingery, Nathan D ^b   Elliott, Hunter L ^b   Xie, Tiao ^b   Gerfen, Charles R ^c   Sabatini, Bernardo L ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; CHOLINE ACETYLTRANSFERASE; GLUTAMATE DECARBOXYLASE 65; VESICULAR ACETYLCHOLINE TRANSPORTER; VESICULAR INHIBITORY AMINO ACID TRANSPORTER; ACETYLCHOLINE; DOPAMINE 2 RECEPTOR; NEUROLEPTIC AGENT;

CYTOLOGY; GENE EXPRESSION; INHIBITOR; PHYLOGENETICS;

4 AMINOBUTYRIC ACID RELEASE; ARTICLE; BASAL GANGLION; BRAIN CORTEX; CORPUS STRIATUM; DORSAL STRIATUM; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; FRONTAL CORTEX; GABAERGIC TRANSMISSION; GLOBUS PALLIDUS; GLOBUS PALLIDUS EXTERNUS; HUMAN; ILLUMINATION; IMMUNOHISTOCHEMISTRY; INTERNEURON; NERVE FIBER; NONHUMAN; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SUBSTANTIA INNOMINATA; SYNAPTOSOME; ANIMAL; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; FEMALE; FRONTAL LOBE; MALE; METABOLISM; MEYNERT BASAL NUCLEUS; MOUSE; NERVE TRACT; RHESUS MONKEY; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ACETYLCHOLINE; ANIMALS; ANTIPSYCHOTIC AGENTS; BASAL NUCLEUS OF MEYNERT; CHOLINE O-ACETYLTRANSFERASE; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; FRONTAL LOBE; GAMMA-AMINOBUTYRIC ACID; GLOBUS PALLIDUS; MACACA MULATTA; MALE; MICE; NEURAL PATHWAYS; RECEPTORS, DOPAMINE D2; SIGNAL TRANSDUCTION;

EID: 84929079352     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14179     Document Type: Article

References (30)

1. Yin, H. H. & Knowlton, B. J. The role of the basal ganglia in habit formation. Nature Rev. Neurosci. 7, 464-476 (2006).
2. Smith, Y., Bevan, M. D., Shink, E. & Bolam, J. P. Microcircuitry of the direct and indirect pathways of the basal ganglia. Neuroscience 86, 353-387 (1998).
3. Kravitz, A. V. et al. Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature 466, 622-626 (2010).
4. Freeze,B.S., Kravitz, A. V.,Hammack, N.,Berke, J.D.&Kreitzer,A.C.Control of basal ganglia output by direct and indirect pathway projection neurons. J. Neurosci. 33, 18531-18539 (2013).
5. Goldberg, J. H., Farries,M. A. & Fee, M. S. Basal ganglia output to the thalamus: still a paradox. Trends Neurosci. 36, 695-705 (2013).
6. Seeman, P. Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1, 133-152 (1987).
7. Tohen,M.&Vieta, E.Antipsychoticagents in the treatment of bipolarmania. Bipolar Disord. 11, 45-54 (2009).
8. Bloch, M. H. et al. A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol. Psychiatry 11, 622-632 (2006).
9. Kita, H. Globus pallidus external segment. Prog. Brain Res. 160, 111-133 (2007).
10. Mesulam, M. M., Mufson, E. J., Levey, A. I. & Wainer, B. H. Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Neuroscience 12, 669-686 (1984).
11. McKinney, M., Coyle, J. T. & Hedreen, J. C. Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system. J. Comp. Neurol. 217, 103-121 (1983).
12. Grove, E. A., Domesick, V. B. & Nauta, W. J. Light microscopic evidence of striatal input to intrapallidal neurons of cholinergic cell group Ch4 in the rat: a study employing the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L). Brain Res. 367, 379-384 (1986).
13. Henderson, Z. The projection fromthe striatumto the nucleus basalis in the rat: an electron microscopic study. Neuroscience 78, 943-955 (1997).
14. Chang, H. T., Penny, G. R. & Kitai, S. T. Enkephalinergic-cholinergic interaction in the rat globus pallidus: a pre-embedding double-labeling immunocytochemistry study. Brain Res. 426, 197-203 (1987).
15. DeLong, M. R. Activity of pallidal neurons during movement. J. Neurophysiol. 34, 414-427 (1971).
16. Schultz, W. Changes in behavior-related neuronal activity in the striatum during learning. Trends Neurosci. 26, 321-328 (2003).
17. Laplane, D. et al. Obsessive-compulsive and other behavioural changes with bilateralbasal ganglia lesions.Aneuropsychological,magnetic resonanceimaging and positron tomography study. Brain 112, 699-725 (1989).
18. Tkatch, T., Baranauskas, G. & Surmeier, D. J. Basal forebrain neurons adjacent to the globus pallidus co-express GABAergic and cholinergic marker mRNAs. Neuroreport 9, 1935-1939 (1998).
19. Mallet, N. et al. Dichotomous organization of the external globus pallidus. Neuron 74, 1075-1086 (2012).
20. Sarter, M. & Bruno, J. P. The neglected constituent of the basal forebrain corticopetal projection system: GABAergic projections. Eur. J. Neurosci. 15, 1867-1873 (2002).
21. Saunders, A., Johnson, C. A. & Sabatini, B. L. Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons. Front. Neural Circuits 6, 47 (2012).
22. Shepherd, G. M. & Harris, K. M. Three-dimensional structure and composition of CA3RCA1 axons in rat hippocampal slices: implications for presynaptic connectivity and compartmentalization. J. Neurosci. 18, 8300-8310 (1998).
23. Nambu, A., Tokuno, H. & Takada, M. Functional significance of the corticosubthalamo- pallidal 'hyperdirect' pathway. Neurosci. Res. 43, 111-117 (2002).
24. Albin, R. L., Young, A. B. & Penney, J. B. The functional anatomy of basal ganglia disorders. Trends Neurosci. 12, 366-375 (1989).
25. Simpson, E. H., Kellendonk, C. & Kandel, E. A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia. Neuron 65, 585-596 (2010).
26. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421-427 (2014).
27. Insel, T. R. Rethinking schizophrenia. Nature 468, 187-193 (2010).
28. Blum, B. P. & Mann, J. J. The GABAergic system in schizophrenia. Int. J. Neuropsychopharmacol. 5, 159-179 (2002).
29. Scarr, E., Gibbons, A. S., Neo, J., Udawela, M. & Dean, B. Cholinergic connectivity: it's implications for psychiatric disorders. Front. Cell. Neurosci. 7, 55 (2013).
30. Lewis, D. A., Hashimoto, T. & Volk, D. W. Cortical inhibitory neurons and schizophrenia. Nature Rev. Neurosci. 6, 312-324 (2005).