The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC

Annals of Oncology

Volumn 26, Issue 5, 2015, Pages 935-942

  Takahashi, Y ^a,b   Sheridan, P ^c   Niida, A ^c   Sawada, G ^a,b   Uchi, R ^a   Mizuno, H ^d   Kurashige, J ^a   Sugimachi, K ^a   Sasaki, S ^e   Shimada, Y ^f   Hase, K ^g   Kusunoki, M ^h   Kudo, S ⁱ   Watanabe, M ^j   Yamada, K ^k   Sugihara, K ^l   Yamamoto, H ^b   Suzuki, A ^m   Doki, Y ^b   Miyano, S ^c   Mori, M ^b   Mimori, Koshi ^a   more..

^a KYUSHU UNIVERSITY BEPPU HOSPITAL   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^e Omori Red Cross Hospital   (Japan)

^f NATIONAL CANCER CENTER HOSPITAL   (Japan)

^g NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^h MIE UNIVERSITY   (Japan)

ⁱ SHOWA UNIVERSITY NORTHERN YOKOHAMA HOSPITAL   (Japan)

^j KITASATO UNIVERSITY   (Japan)

^k TAKANO HOSPITAL   (Japan)

^l TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^m KYUSHU UNIVERSITY   (Japan)

more..

Author keywords

AURKA; Co amplification; MYC; Synthetic lethality; TPX2

Indexed keywords

ARTICLE; AURKA GENE; BIOINFORMATICS; CANCER GROWTH; CANCER SURVIVAL; CHROMOSOME 20Q; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; FIBROBLAST CULTURE; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INTERACTION; GENE LOCATION; GENE LOCUS; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; ONCOGENE; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TPX2 GENE; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOLOGY; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME 20; CHROMOSOME 8; COLORECTAL TUMOR; DRUG EFFECTS; ENZYMOLOGY; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; HCT116 CELL LINE; METABOLISM; MORTALITY; PATHOLOGY; PROGNOSIS; RNA INTERFERENCE; SURVIVAL ANALYSIS; TIME FACTOR;

ANTINEOPLASTIC AGENT; AURKA PROTEIN, HUMAN; AURORA A KINASE; CELL CYCLE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MYC PROTEIN; MYC PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN KINASE INHIBITOR; TPX2 PROTEIN, HUMAN;

ANTINEOPLASTIC AGENTS; AURORA KINASE A; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOMES, HUMAN, PAIR 20; CHROMOSOMES, HUMAN, PAIR 8; COLORECTAL NEOPLASMS; COMPUTATIONAL BIOLOGY; GENE AMPLIFICATION; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; PROGNOSIS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TIME FACTORS; TRANSFECTION;

EID: 84929078584     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdv034     Document Type: Article

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