Metabostemness: Metaboloepigenetic reprogramming of cancer stem-cell functions

Oncoscience

Volumn 1, Issue 12, 2014, Pages 803-806

  Menendez, Javier A ^a,b   Corominas Faja, Bruna ^a,b   Cuyàs, Elisabet ^a,b   Alarcón, Tomás ^c,d  

^a CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^b GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^c CENTRE DE RECERCA MATEMÀTICA   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Cancer; Cancer stem cells; Oncometabolites; Reprogramming; Stem cells; Stemness

Indexed keywords

EID: 84929076729     PISSN: None     EISSN: 23314737     Source Type: Journal    
DOI: 10.18632/oncoscience.113     Document Type: Article

References (17)

1. Goding CR, Pei D, Lu X. Cancer: pathological nuclear reprogramming? Nat Rev Cancer. 2014; 14: 568-573.
2. Yang M, Soga T, Pollard PJ. Oncometabolites: linking altered metabolism with cancer. J Clin Invest. 2013; 123: 3652-3658.
3. Saha SK, Parachoniak CA, Ghanta KS, Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J, Popovici-Muller J, Gliser C, Ferrone CR, Apte U, Llovet JM, Wong KK, Ramaswamy S, Bardeesy N. Mutant IDH inhibits HNF 4a to block hepatocyte differentiation and promote biliary cancer. Nature. 2014; 513:110-114.
4. Terunuma A, Putluri N, Mishra P, Mathé EA, Dorsey TH, Yi M, Wallace TA, Issaq HJ, Zhou M, Killian JK, Stevenson HS, Karoly ED, Chan K, Samanta S, Prieto D, Hsu TY, Kurley SJ, Putluri V, Sonavane R, Edelman DC, Wulff J, Starks AM, Yang Y, Kittles RA, Yfantis HG, Lee DH, Ioffe OB, Schiff R, Stephens RM, Meltzer PS, Veenstra TD, Westbrook TF, Sreekumar A, Ambs S. MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis. J Clin Invest. 2014; 124: 398-412.
5. Huang S. Reprogramming cell fates: reconciling rarity with robustness. Bioessays. 2009; 31: 546-560.
6. Huang S, Ernberg I, Kauffman S. Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective. Semin Cell Dev Biol. 2009; 20: 869-876.
7. Hanna JH, Saha K, Jaenisch R. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell. 2010; 143: 508-525.
8. Huang S. The molecular and mathematical basis of Waddington's epigenetic landscape: a framework for post-Darwinian biology? Bioessays. 2012; 34: 149-157.
9. Menendez JA, Alarcón T. Metabostemness: A new cancer hallmark. Front Oncol. 2014: 4: 262.
10. Lu C, Thompson CB. Metabolic regulation of epigenetics. Cell Metab. 2012; 16: 9-17.
11. Mariani CJ, Vasanthakumar A, Madzo J, Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL, Nanduri J, Verma A, Prabhakar NR, Godley LA. TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma. Cell Rep. 2014; 7: 1343-1352.
12. Hjelmeland AB, Wu Q, Heddleston JM, Choudhary GS, MacSwords J, Lathia JD, McLendon R, Lindner D, Sloan A, Rich JN. Acidic stress promotes a glioma stem cell phenotype. Cell Death Differ. 2011; 18: 829-840.
13. Shim EH, Livi CB, Rakheja D, Tan J, Benson D, Parekh V, Kho EY, Ghosh AP, Kirkman R, Velu S, Dutta S, Chenna B, Rea SL, Mishur RJ, Li Q, Johnson-Pais TL, Guo L, Bae S, Wei S, Block K, Sudarshan S. l-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer. Cancer Discov. 2014; 4: 1290-1298.
14. Nam H, Campodonico M, Bordbar A, Hyduke DR, Kim S, Zielinski DC3, Palsson BO5. A Systems Approach to Predict Oncometabolites via Context-Specific Genome-Scale Metabolic Networks. PLoS Comput Biol. 2014; 10, e1003837.
15. Pollak M. Potential applications for biguanides in oncology. J Clin Invest. 2013; 123: 3693-3700.
16. Hirsch HA, Iliopoulos D, Struhl K. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci USA. 2013; 110: 972-977.
17. Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc Natl Acad Sci USA. 2014; 111: 10574-10579.