-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011;144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
0024473604
-
G1 events and regulation of cell proliferation
-
Pardee AB. G1 events and regulation of cell proliferation. Science 1989;246:603-608.
-
(1989)
Science
, vol.246
, pp. 603-608
-
-
Pardee, A.B.1
-
4
-
-
0031466305
-
Cyclin-dependent kinases: Engines, clocks, and microprocessors
-
Morgan DO. Cyclin-dependent kinases: Engines, clocks, and microprocessors. Annu Rev Cell Dev Biol 1997;13:261-291.
-
(1997)
Annu Rev Cell Dev Biol
, vol.13
, pp. 261-291
-
-
Morgan, D.O.1
-
6
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-330.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
7
-
-
77954757207
-
Therapeutic CDK4/6 inhibition in breast cancer: Key mechanisms of response and failure
-
Dean JL, Thangavel C, McClendon AK et al. Therapeutic CDK4/6 inhibition in breast cancer: Key mechanisms of response and failure. Oncogene 2010;29:4018-4032.
-
(2010)
Oncogene
, vol.29
, pp. 4018-4032
-
-
Dean, J.L.1
Thangavel, C.2
McClendon, A.K.3
-
8
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
Sherr CJ, Roberts JM. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-1512.
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
9
-
-
33645802169
-
Cyclin-dependent kinase pathways as targets for cancer treatment
-
Shapiro GI. Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 2006; 24:1770-1783.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1770-1783
-
-
Shapiro, G.I.1
-
10
-
-
0037050256
-
Suppression of neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin
-
Bowe DB, Kenney NJ, Adereth Y et al. Suppression of neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E. Oncogene 2002;21:291-298.
-
(2002)
E. Oncogene
, vol.21
, pp. 291-298
-
-
Bowe, D.B.1
Kenney, N.J.2
Adereth, Y.3
-
11
-
-
30344479175
-
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
-
Landis MW, Pawlyk BS, Li T et al. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 2006;9: 13-22.
-
(2006)
Cancer Cell
, vol.9
, pp. 13-22
-
-
Landis, M.W.1
Pawlyk, B.S.2
Li, T.3
-
12
-
-
0035963435
-
Specific protection against breast cancers by cyclin D1 ablation
-
Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001;411:1017-1021.
-
(2001)
Nature
, vol.411
, pp. 1017-1021
-
-
Yu, Q.1
Geng, Y.2
Sicinski, P.3
-
13
-
-
30344470210
-
Requirement for CDK4 kinase function in breast cancer
-
Yu Q, Sicinska E, Geng Y et al. Requirement for CDK4 kinase function in breast cancer. Cancer Cell 2006;9:23-32.
-
(2006)
Cancer Cell
, vol.9
, pp. 23-32
-
-
Yu, Q.1
Sicinska, E.2
Geng, Y.3
-
14
-
-
28544433465
-
Cyclindependent kinase 4 expression is essential for neuinduced breast tumorigenesis
-
Reddy HK, Mettus RV, Rane SG et al. Cyclindependent kinase 4 expression is essential for neuinduced breast tumorigenesis. Cancer Res 2005;65: 10174-10178.
-
(2005)
Cancer Res
, vol.65
, pp. 10174-10178
-
-
Reddy, H.K.1
Mettus, R.V.2
Rane, S.G.3
-
15
-
-
84867618851
-
The requirement for cyclin D function in tumor maintenance
-
Choi YJ, Li X, Hydbring P et al. The requirement for cyclin D function in tumor maintenance. Cancer Cell 2012;22:438-451.
-
(2012)
Cancer Cell
, vol.22
, pp. 438-451
-
-
Choi, Y.J.1
Li, X.2
Hydbring, P.3
-
16
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
The Cancer Genome Atlas Network
-
The Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012;490:61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
17
-
-
84863256545
-
ChIP sequencing of cyclinD1reveals a transcriptional role in chromosomal instability in mice
-
Casimiro MC, Crosariol M, Loro E et al. ChIP sequencing of cyclinD1reveals a transcriptional role in chromosomal instability in mice. J Clin Invest 2012;122:833-843.
-
(2012)
J Clin Invest
, vol.122
, pp. 833-843
-
-
Casimiro, M.C.1
Crosariol, M.2
Loro, E.3
-
18
-
-
84879377397
-
New roles of cyclin D1
-
Pestell RG. New roles of cyclin D1. Am J Pathol 2013;183:3-9.
-
(2013)
Am J Pathol
, vol.183
, pp. 3-9
-
-
Pestell, R.G.1
-
19
-
-
84881528286
-
A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis
-
Kollmann K, Heller G, Schneckenleithner C et al. A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell 2013;24:167-181.
-
(2013)
Cancer Cell
, vol.24
, pp. 167-181
-
-
Kollmann, K.1
Heller, G.2
Schneckenleithner, C.3
-
23
-
-
33846254185
-
Aphase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days
-
Benson C, White J, De Bono J et al. Aphase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days. Br JCancer 2007;96:29-37.
-
(2007)
Br Jcancer
, vol.96
, pp. 29-37
-
-
Benson, C.1
White, J.2
De Bono, J.3
-
24
-
-
80054752304
-
The CDK inhibitors in cancer research and therapy
-
Cicenas J, Valius M. The CDK inhibitors in cancer research and therapy. J Cancer Res Clin Oncol 2011;137:1409-1418.
-
(2011)
J Cancer Res Clin Oncol
, vol.137
, pp. 1409-1418
-
-
Cicenas, J.1
Valius, M.2
-
25
-
-
84929106662
-
-
Accessed November 4, 2014
-
Search results: Roscovitine AND breast cancer. Available at http://clinicaltrials.gov/ct2/results?term5roscovitine1AND1breast1cancer. Accessed November 4, 2014.
-
Search Results: Roscovitine AND Breast Cancer
-
-
-
26
-
-
84919780318
-
Highlights of the latest advances in research on CDK inhibitors
-
Cicenas J, Kalyan K, Sorokinas A et al. Highlights of the latest advances in research on CDK inhibitors. Cancers (Basel) 2014;6:2224-2242.
-
(2014)
Cancers (Basel)
, vol.6
, pp. 2224-2242
-
-
Cicenas, J.1
Kalyan, K.2
Sorokinas, A.3
-
27
-
-
0029807115
-
Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy
-
Sedlacek H, Czech J, Naik R et al. Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy. Int J Oncol 1996;9:1143-1168.
-
(1996)
Int J Oncol
, vol.9
, pp. 1143-1168
-
-
Sedlacek, H.1
Czech, J.2
Naik, R.3
-
28
-
-
0037086282
-
Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase
-
Matranga CB, Shapiro GI. Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase. Cancer Res 2002;62:1707-1717.
-
(2002)
Cancer Res
, vol.62
, pp. 1707-1717
-
-
Matranga, C.B.1
Shapiro, G.I.2
-
29
-
-
84868139125
-
Cyclindependent kinase modulators and cancer therapy
-
Gallorini M, Cataldi A, di Giacomo V. Cyclindependent kinase modulators and cancer therapy. BioDrugs 2012;26:377-391.
-
(2012)
Biodrugs
, vol.26
, pp. 377-391
-
-
Gallorini, M.1
Cataldi, A.2
Di Giacomo, V.3
-
30
-
-
35348859609
-
Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors
-
Fornier MN, Rathkopf D, Shah M et al. Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors. Clin Cancer Res 2007;13:5841-5846.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5841-5846
-
-
Fornier, M.N.1
Rathkopf, D.2
Shah, M.3
-
31
-
-
0029665447
-
17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G (1)-arrested human breast cancer cells
-
Altucci L, Addeo R, Cicatiello L et al. 17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G (1)-arrested human breast cancer cells. Oncogene 1996;12:2315-2324.
-
(1996)
Oncogene
, vol.12
, pp. 2315-2324
-
-
Altucci, L.1
Addeo, R.2
Cicatiello, L.3
-
32
-
-
8044219665
-
Estrogen induces early and timed activation of cyclindependent kinases 4, 5, and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus
-
Altucci L, Addeo R, Cicatiello L et al. Estrogen induces early and timed activation of cyclindependent kinases 4, 5, and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus. Endocrinology 1997;138:978-984.
-
(1997)
Endocrinology
, vol.138
, pp. 978-984
-
-
Altucci, L.1
Addeo, R.2
Cicatiello, L.3
-
33
-
-
0030888284
-
Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclinD1expressionanddecreased cyclindependent kinase inhibitor association with cyclin E-Cdk2
-
Prall OW, Sarcevic B, Musgrove EA et al. Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclinD1expressionanddecreased cyclindependent kinase inhibitor association with cyclin E-Cdk2. J Biol Chem 1997;272:10882-10894.
-
(1997)
J Biol Chem
, vol.272
, pp. 10882-10894
-
-
Prall, O.W.1
Sarcevic, B.2
Musgrove, E.A.3
-
34
-
-
0028786916
-
Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclindependent kinase activity and decreased retinoblastoma protein phosphorylation
-
Watts CK, Brady A, Sarcevic B et al. Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclindependent kinase activity and decreased retinoblastoma protein phosphorylation. Mol Endocrinol 1995;9:1804-1813.
-
(1995)
Mol Endocrinol
, vol.9
, pp. 1804-1813
-
-
Watts, C.K.1
Brady, A.2
Sarcevic, B.3
-
35
-
-
84883258960
-
Cyclin D1 determines estrogen signaling in the mammary gland in vivo
-
Casimiro MC, Wang C, Li Z et al. Cyclin D1 determines estrogen signaling in the mammary gland in vivo. Mol Endocrinol 2013;27:1415-1428.
-
(2013)
Mol Endocrinol
, vol.27
, pp. 1415-1428
-
-
Casimiro, M.C.1
Wang, C.2
Li, Z.3
-
36
-
-
79960100823
-
Therapeutically activating RB: Reestablishing cell cycle control in endocrinetherapy-resistant breast cancer
-
Thangavel C, Dean JL, Ertel A et al. Therapeutically activating RB: Reestablishing cell cycle control in endocrinetherapy-resistant breast cancer. Endocr Relat Cancer 2011;18:333-345.
-
(2011)
Endocr Relat Cancer
, vol.18
, pp. 333-345
-
-
Thangavel, C.1
Dean, J.L.2
Ertel, A.3
-
37
-
-
76049104235
-
PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro
-
Finn RS, Dering J, Conklin D et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res 2009;11:R77.
-
(2009)
Breast Cancer Res
, vol.11
, pp. 77
-
-
Finn, R.S.1
Dering, J.2
Conklin, D.3
-
38
-
-
9444228344
-
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
-
Fry DW, Harvey PJ, Keller PR et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 2004;3: 1427-1438.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1427-1438
-
-
Fry, D.W.1
Harvey, P.J.2
Keller, P.R.3
-
39
-
-
77951082119
-
Pharmacologic inhibition ofcyclin-dependent kinases 4and6arreststhegrowthofglioblastomamultiforme intracranial xenografts
-
Michaud K, Solomon DA, Oermann E et al. Pharmacologic inhibition ofcyclin-dependent kinases 4and6arreststhegrowthofglioblastomamultiforme intracranial xenografts. Cancer Res 2010;70:3228-3238.
-
(2010)
Cancer Res
, vol.70
, pp. 3228-3238
-
-
Michaud, K.1
Solomon, D.A.2
Oermann, E.3
-
40
-
-
84859079523
-
Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy
-
Roberts PJ, Bisi JE, Strum JC et al. Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. J Natl Cancer Inst 2012;104:476-487.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 476-487
-
-
Roberts, P.J.1
Bisi, J.E.2
Strum, J.C.3
-
41
-
-
79958149971
-
Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1)
-
Schwartz GK, LoRusso PM, Dickson MA et al. Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1). Br J Cancer 2011;104:1862-1868.
-
(2011)
Br J Cancer
, vol.104
, pp. 1862-1868
-
-
Schwartz, G.K.1
Lorusso, P.M.2
Dickson, M.A.3
-
42
-
-
84855983664
-
Phase I, dose-escalation trial of the oral cyclindependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer
-
Flaherty KT, Lorusso PM, Demichele A et al. Phase I, dose-escalation trial of the oral cyclindependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer. Clin Cancer Res 2012;18:568-576.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 568-576
-
-
Flaherty, K.T.1
Lorusso, P.M.2
Demichele, A.3
-
43
-
-
84892722398
-
A phase II trial of an oral CDK 4/6 inhibitor, PD0332991, in advanced breast cancer
-
DeMichele A, Sanders Clark A, Heitian D et al. A phase II trial of an oral CDK 4/6 inhibitor, PD0332991, in advanced breast cancer. J Clin Oncol 2013;31(suppl):519a.
-
(2013)
J Clin Oncol
, vol.31
-
-
Demichele, A.1
Sanders Clark, A.2
Heitian, D.3
-
44
-
-
0036304429
-
Approval summary: Letrozole in the treatment of postmenopausal women with advanced breast cancer
-
Cohen MH, Johnson JR, Li N et al. Approval summary: Letrozole in the treatment of postmenopausal women with advanced breast cancer. Clin Cancer Res 2002;8:665-669.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 665-669
-
-
Cohen, M.H.1
Johnson, J.R.2
Li, N.3
-
45
-
-
80054733690
-
Phase I study of PD-0332991, cyclin-D kinase (CDK) 4/6 inhibitor in combination with letrozole for firstline treatment of patients with ER-positive, HER2-negative breast cancer
-
Slamon DJ, Hurvitz SA, Applebaum S et al. Phase I study of PD-0332991, cyclin-D kinase (CDK) 4/6 inhibitor in combination with letrozole for firstline treatment of patients with ER-positive, HER2-negative breast cancer. J Clin Oncol 2010;28(suppl): 3060a.
-
(2010)
J Clin Oncol
, vol.28
-
-
Slamon, D.J.1
Hurvitz, S.A.2
Applebaum, S.3
-
46
-
-
84929106663
-
-
Poster presented at: San Antonio Breast Cancer Symposium; December 6-10, San Antonio, TX
-
Finn RS, Crown JP, Boer K et al. Preliminary results of a randomized phase II study of PD 0332991, a cyclin-dependent kinase 4/6 inhibitor, in combination with letrozole for first-line treatment of patients with post-menopausal, ER-positive, HER2-negative advanced breast cancer. Poster presented at: San Antonio Breast Cancer Symposium; December 6-10, 2011; San Antonio, TX.
-
(2011)
Preliminary Results of a Randomized Phase II Study of PD 0332991, a Cyclin-Dependent Kinase 4/6 Inhibitor, in Combination with Letrozole for First-Line Treatment of Patients with Post-Menopausal, Er-Positive, Her2-Negative Advanced Breast Cancer
-
-
Finn, R.S.1
Crown, J.P.2
Boer, K.3
-
47
-
-
84871802610
-
Results of a randomized phase II study of PD-0332991, a cyclin dependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ER1/HER2-advanced breast cancer (BC) [abstract 1000]
-
Finn RS, Crown JP, Boer K et al. Results of a randomized phase II study of PD-0332991, a cyclin dependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ER1/HER2-advanced breast cancer (BC) [abstract 1000]. Ann Oncol 2012;23(suppl 2):ii43-ii45.
-
(2012)
Ann Oncol
, vol.23
-
-
Finn, R.S.1
Crown, J.P.2
Boer, K.3
-
48
-
-
84922369296
-
The cyclindependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptorpositive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): A randomised phase 2 study
-
Finn RS, Crown JP, Lang I et al. The cyclindependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptorpositive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): A randomised phase 2 study. Lancet Oncol 2015;16:25-35.
-
(2015)
Lancet Oncol
, vol.16
, pp. 25-35
-
-
Finn, R.S.1
Crown, J.P.2
Lang, I.3
-
50
-
-
84929070191
-
-
Accessed February 24, 2015
-
NDA 207103: Accelerated approval. Available at http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2015/207103Orig1s000ltr.pdf.Accessed February 24, 2015.
-
NDA 207103: Accelerated Approval
-
-
-
51
-
-
84929106664
-
-
Accessed February 24, 2015
-
Ibrance (palbociclib) [prescribing information]. Available at http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207103s000lbl.pdf. Accessed February 24, 2015.
-
Ibrance (Palbociclib) [Prescribing Information]
-
-
-
54
-
-
84929106665
-
-
Accessed November 4, 2014
-
Search results: Palbociclib AND breast cancer. Available at http://clinicaltrials.gov/ct2/results?term5palbociclib1AND1breast1cancer. Accessed November 4, 2014.
-
Search Results: Palbociclib AND Breast Cancer
-
-
-
55
-
-
85084273947
-
Targeting CDK4/6 in HER2 positive breast cancer: Therapeutic effect, markers and combination strategies
-
Knudsen E, Cox D, Franco J et al. Targeting CDK4/6 in HER2 positive breast cancer: Therapeutic effect, markers and combination strategies. Ann Oncol 2014;25(suppl 1):i21.
-
(2014)
Ann Oncol
, vol.25
-
-
Knudsen, E.1
Cox, D.2
Franco, J.3
-
56
-
-
84961711380
-
CDK4/6 inhibition provides a potent adjunct to Her2- targeted therapies in preclinical breast cancer models
-
Witkiewicz AK, Cox D, Knudsen ES. CDK4/6 inhibition provides a potent adjunct to Her2- targeted therapies in preclinical breast cancer models. Genes Cancer 2014;5:261-272.
-
(2014)
Genes Cancer
, vol.5
, pp. 261-272
-
-
Witkiewicz, A.K.1
Cox, D.2
Knudsen, E.S.3
-
57
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma S, Miles D, Gianni L et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012;367:1783-1791.
-
(2012)
N Engl J Med
, vol.367
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
-
60
-
-
84903829287
-
LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6-reactivating Rb in cancer
-
Kim S, Loo A, Chopra R et al. LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6-reactivating Rb in cancer. Mol Cancer Ther 2013;12(suppl):PR02a.
-
(2013)
Mol Cancer Ther
, vol.12
-
-
Kim, S.1
Loo, A.2
Chopra, R.3
-
61
-
-
84905669286
-
A phase I study of the single-agent CDK4/6 inhibitor LEE011 in pts with advanced solid tumors and lymphomas
-
Infante JR, Shapiro G, Witteveen P et al. A phase I study of the single-agent CDK4/6 inhibitor LEE011 in pts with advanced solid tumors and lymphomas. J Clin Oncol 2014;32(suppl):2528a.
-
J Clin Oncol
, vol.32
-
-
Infante, J.R.1
Shapiro, G.2
Witteveen, P.3
-
62
-
-
84929106666
-
-
Accessed November 4, 2014
-
Search results: LEE011 | open studies. Available at http://clinicaltrials.gov/ct2/results?term5LEE011&recr5Open. Accessed November 4, 2014.
-
Search Results: LEE011 | Open Studies
-
-
-
65
-
-
84904259645
-
CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors
-
Vora SR, Juric D, Kim N et al. CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors. Cancer Cell 2014;26:136-149.
-
(2014)
Cancer Cell
, vol.26
, pp. 136-149
-
-
Vora, S.R.1
Juric, D.2
Kim, N.3
-
66
-
-
84926023132
-
Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER1 /HER2-metastatic breast cancer
-
Bardia A, Modi S, Chavez-Mac Gregor M et al. Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER1 /HER2-metastatic breast cancer. J Clin Oncol 2014; 32(suppl):535a.
-
(2014)
J Clin Oncol
, vol.32
-
-
Bardia, A.1
Modi, S.2
Chavez-Mac Gregor, M.3
-
67
-
-
84924953598
-
Phase lb studyof LEE011 and BYL719 incombination with letrozole in estrogen receptor-positive, HER2-negative breastcancer (ER1,HER2- BC)
-
Munster PN, Paige Hamilton E, Franklin C et al. Phase lb studyof LEE011 and BYL719 incombination with letrozole in estrogen receptor-positive, HER2-negative breastcancer (ER1,HER2- BC). JClin Oncol 2014;32(suppl):533a.
-
(2014)
Jclin Oncol
, vol.32
-
-
Munster, P.N.1
Paige Hamilton, E.2
Franklin, C.3
-
70
-
-
84903844127
-
Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) with broad in vivo antitumor activity
-
Gelbert LM, Cai S, Lin X et al. Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) with broad in vivo antitumor activity. Mol Cancer Ther 2011;10(suppl):B233a.
-
(2011)
Mol Cancer Ther
, vol.10
-
-
Gelbert, L.M.1
Cai, S.2
Lin, X.3
-
71
-
-
84903842102
-
LY2835219, a potent oral inhibitor of the cyclindependent kinases4and 6(CDK4/6) that crossesthe blood-brain barrier and demonstrates in vivo activity against intracranial human brain tumor xenografts
-
Sanchez-Martinez C, Gelbert LM, Shannon H et al. LY2835219, a potent oral inhibitor of the cyclindependent kinases4and 6(CDK4/6) that crossesthe blood-brain barrier and demonstrates in vivo activity against intracranial human brain tumor xenografts. Mol Cancer Ther 2011;10(suppl):B234a.
-
(2011)
Mol Cancer Ther
, vol.10
-
-
Sanchez-Martinez, C.1
Gelbert, L.M.2
Shannon, H.3
-
72
-
-
84904386603
-
LY2835219, a selective inhibitor of CDK4 and CDK6, inhibits growth in preclinical models of human cancer
-
Dempsey JA, Chan EM, Burke TF et al. LY2835219, a selective inhibitor of CDK4 and CDK6, inhibits growth in preclinical models of human cancer. Cancer Res 2013;73(suppl):LB-122a.
-
(2013)
Cancer Res
, vol.73
-
-
Dempsey, J.A.1
Chan, E.M.2
Burke, T.F.3
-
73
-
-
84891011530
-
Study of the CDK4/6 inhibitor, LY2835219, for patients with advanced cancer
-
Shapiro G, Rosen LS, Tolcher AW. A first-inhuman phase I study of the CDK4/6 inhibitor, LY2835219, for patients with advanced cancer. J Clin Oncol 2013;31(suppl):2500a.
-
J Clin Oncol
, vol.31
-
-
Shapiro, G.1
Rosen, L.S.2
Tolcher, A.3
First-Inhuman Phase, I.4
-
74
-
-
84929106668
-
-
Presented at: American Association for Cancer Research annual meeting; April 5-9, 2014; San Diego, CA
-
Patnaik A, Rosen LS, Tolaney SM et al. Clinical activity of LY2835219, a novel cell cycle inhibitor selective for CDK4 and CDK6, in patients with metastatic breast cancer [abstract CT232]. Presented at: American Association for Cancer Research annual meeting; April 5-9, 2014; San Diego, CA.
-
Clinical Activity of LY2835219, a Novel Cell Cycle Inhibitor Selective for CDK4 and CDK6, in Patients with Metastatic Breast Cancer [Abstract CT232]
-
-
Patnaik, A.1
Rosen, L.S.2
Tolaney, S.M.3
-
75
-
-
84923794403
-
LY2835219, a novel cell cycle inhibitor selective for CDK4/6, in combinationwith fulvestrant for patients with hormone receptor positive (HR1) metastatic breast cancer
-
Patnaik A, Rosen LS, Tolaney SM et al. LY2835219, a novel cell cycle inhibitor selective for CDK4/6, in combinationwith fulvestrant for patients with hormone receptor positive (HR1) metastatic breast cancer. J Clin Oncol 2014;32(suppl):534a.
-
(2014)
J Clin Oncol
, vol.32
-
-
Patnaik, A.1
Rosen, L.S.2
Tolaney, S.M.3
-
76
-
-
84929106669
-
-
Accessed November 4, 2014
-
Search results: LY2835219 | open studies. Available at http://clinicaltrials.gov/ct2/results?term5LY2835219&recr5Open. Accessed November 4, 2014.
-
Search Results: LY2835219 | Open Studies
-
-
-
80
-
-
84865254684
-
Modification of the DNA damage response by therapeutic CDK4/6 inhibition
-
Dean JL, McClendon AK, Knudsen ES. Modification of the DNA damage response by therapeutic CDK4/6 inhibition. J Biol Chem 2012;287:29075-29087.
-
(2012)
J Biol Chem
, vol.287
, pp. 29075-29087
-
-
Dean, J.L.1
McClendon, A.K.2
Knudsen, E.S.3
-
82
-
-
84929088783
-
-
Accessed February 24, 2015
-
Pfizer breast cancer drug gets early FDA approval. Available at http://finance.yahoo.com/news/pfizer-breast-cancer-drug-gets-225132522.html. Accessed February 24, 2015.
-
Pfizer Breast Cancer Drug Gets Early FDA Approval
-
-
|