Role of Ca2+/calmodulin-dependent protein kinase kinase in adrenal aldosterone production

Endocrinology

Volumn 156, Issue 5, 2015, Pages 1750-1756

  Nanba, Kazutaka ^a   Chen, Andrew ^a   Nishimoto, Koshiro ^a   Rainey, William E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE I; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE INHIBITOR; SHORT HAIRPIN RNA; STEROIDOGENIC ACUTE REGULATORY PROTEIN; STO 609; UNCLASSIFIED DRUG; BENZIMIDAZOLE DERIVATIVE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CAMKK1 PROTEIN, HUMAN; CAMKK2 PROTEIN, HUMAN; NAPHTHALIMIDE DERIVATIVE; PHOSPHOPROTEIN; POTASSIUM; SMALL INTERFERING RNA; VASOCONSTRICTOR AGENT;

ADRENAL GLAND; ARTICLE; CALCIUM SIGNALING; GENE SILENCING; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INVESTIGATIVE PROCEDURES; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; WESTERN BLOTTING; ZONA GLOMERULOSA; ADRENAL CORTEX; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADRENAL CORTEX; ALDOSTERONE; ANGIOTENSIN II; BENZIMIDAZOLES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CELL LINE; CYTOCHROME P-450 CYP11B2; GENE KNOCKDOWN TECHNIQUES; HUMANS; NAPHTHALIMIDES; PHOSPHOPROTEINS; POTASSIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; VASOCONSTRICTOR AGENTS;

EID: 84929000356     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1782     Document Type: Article

References (32)

1. Brown NJ. Aldosterone and vascular inflammation. Hypertension. 2008;51(2):161-167.
2. Marney AM, Brown NJ. Aldosterone and end-organ damage. Clin Sci (Lond). 2007;113(6):267-278.
3. Rossi GP, Bernini G, Caliumi C, et al. A prospective study of the prevalence of primary aldosteronism in 1, 125 hypertensive patients. J Am Coll Cardiol. 2006;48(11):2293-2300.
4. Young WF. Primary aldosteronism: renaissance of a syndrome. Clin Endocrinol. 2007;66(5):607-618.
5. Rossi GP, Pessina AC, Heagerty AM. Primary aldosteronism: an update on screening, diagnosis and treatment. J Hypertens. 2008; 26(4):613-621.
6. Choi M, Scholl UI, Yue P, et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011;331(6018):768-772.
7. Monticone S, Hattangady NG, Nishimoto K, et al. Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. J Clin Endocrinol Metab. 2012;97(8): E1567-E1572.
8. Beuschlein F, Boulkroun S, Osswald A, et al. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet. 2013;45(4):440-444, 444e441- 442.
9. Scholl UI, GohG, Stölting G, et al. Somatic and germlineCACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nat Genet. 2013;45(9):1050-1054.
10. Azizan EA, Poulsen H, Tuluc P, et al. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet. 2013;45(9):1055-1060.
11. Hattangady NG, Olala LO, Bollag WB, Rainey WE. Acute and chronic regulation of aldosterone production. Mol Cell Endocrinol. 2012;350(2):151-162.
12. Bassett MH, White PC, Rainey WE. The regulation of aldosterone synthase expression. Mol Cell Endocrinol. 2004;217(1-2):67-74.
13. Denner K, Rainey WE, Pezzi V, Bird IM, Bernhardt R, Mathis JM. Differential regulation of 11 β-hydroxylase and aldosterone synthase in human adrenocortical H295R cells. Mol Cell Endocrinol. 1996;121(1):87-91.
14. Spät A, Hunyady L. Control of aldosterone secretion: a model for convergence in cellular signaling pathways. Physiol Rev. 2004; 84(2):489-539.
15. Spat A. Glomerulosa cell-a unique sensor of extracellular K+ concentration. Mol Cell Endocrinol. 2004;217(1-2):23-26.
16. Condon JC, Pezzi V, Drummond BM, Yin S, Rainey WE. Calmodulin- dependent kinase I regulates adrenal cell expression of aldosterone synthase. Endocrinology. 2002;143(9):3651-3657.
17. Parmar J, Key RE, Rainey WE. Development of an adrenocorticotropin-responsive human adrenocortical carcinoma cell line. J Clin Endocrinol Metab. 2008;93(11):4542-4546.
18. Tokumitsu H, Inuzuka H, Ishikawa Y, Ikeda M, Saji I, Kobayashi R. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002;277(18):15813-15818.
19. Ye P, Mariniello B, Mantero F, Shibata H, Rainey WE. G-proteincoupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism. J Endocrinol. 2007;195(1):39-48.
20. Nogueira EF, Xing Y, Morris CA, Rainey WE. Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis. J Mol Endocrinol. 2009;42(4):319-330.
21. Gomez-Sanchez CE, Qi X, Velarde-Miranda C, et al. Development of monoclonal antibodies against human CYP11B1 and CYP11B2. Mol Cell Endocrinol. 2014;383(1-2):111-117.
22. Nishimoto K, Rigsby CS, Wang T, et al. Transcriptome analysis reveals differentially expressed transcripts in rat adrenal zona glomerulosa and zona fasciculata. Endocrinology. 2012;153(4):1755-1763.
23. Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA. The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem. 2005; 280(32):29060-29066.
24. Soderling TR. The Ca-calmodulin-dependent protein kinase cascade. Trends Biochem Sci. 1999;24(6):232-236.
25. Pezzi V, Clark BJ, Ando S, Stocco DM, Rainey WE. Role of calmodulin- dependent protein kinase II in the acute stimulation of aldosterone production. J Steroid Biochem Mol Biol. 1996;58(4):417-424.
26. Pezzi V, Clyne CD, Ando S, Mathis JM, Rainey WE. Ca(2+)-regulated expression of aldosterone synthase is mediated by calmodulin and calmodulin-dependent protein kinases. Endocrinology. 1997; 138(2):835-838.
27. Racioppi L, Means AR. Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. J Biol Chem. 2012;287(38):31658-31665.
28. Fujisawa H. Regulation of the activities of multifunctional Ca2+/ calmodulin-dependent protein kinases. J Biochem. 2001;129(2): 193-199.
29. Wayman GA, Tokumitsu H, Davare MA, Soderling TR. Analysis of CaM-kinase signaling in cells. Cell Calcium. 2011;50(1):1-8.
30. Tokumitsu H, Enslen H, Soderling TR. Characterization of a Ca2+/ calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase. J Biol Chem. 1995;270(33):19320-19324.
31. Anderson KA, Means RL, Huang QH, et al. Components of a calmodulin- dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin- dependent protein kinase kinase β. J Biol Chem. 1998;273(48): 31880-31889.
32. Corcoran EE, Means AR. Defining Ca2+/calmodulin-dependent protein kinase cascades in transcriptional regulation. J Biol Chem. 2001;276(5):2975-2978.