Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Gao, Fu ^a   Liu, Cong ^a   Guo, Jiaming ^a   Sun, Weimin ^a   Xian, Linfeng ^a   Bai, Dongchen ^a   Liu, Hu ^a   Cheng, Ying ^a   Li, Bailong ^a   Cui, Jianguo ^a   Zhang, Chaoxiong ^b   Cai, Jianming ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b National Key Laboratory of Medical Immunology Institute of Immunology Second Military Medical University ^*  (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CYTOKINE; FATTY ACID BINDING PROTEIN; LIPOPROTEIN LIPASE; TRIACYLGLYCEROL;

ADVERSE EFFECTS; ANIMAL; BLOOD; C57BL MOUSE; CARCINOGENESIS; DENDRITIC CELL; GAMMA RADIATION; LIPID DIET; LIPID METABOLISM; LYMPHOMA; METABOLISM; MOUSE; PATHOLOGY; RADIATION RESPONSE; T LYMPHOCYTE; THYMOMA; TRANSGENIC MOUSE; UPREGULATION;

ACETYL-COA CARBOXYLASE; ANIMALS; CARCINOGENESIS; CYTOKINES; DENDRITIC CELLS; DIET, HIGH-FAT; FATTY ACID-BINDING PROTEINS; GAMMA RAYS; LIPID METABOLISM; LIPOPROTEIN LIPASE; LYMPHOMA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; T-LYMPHOCYTES; THYMUS NEOPLASMS; TRIGLYCERIDES; UP-REGULATION;

EID: 84928964292     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09613     Document Type: Article

References (33)

1. Little, J. B. Radiation carcinogenesis. Carcinogenesis 21, 397-404 (2000).
2. Potworowski, E. F., Gagnon, F., Beauchemin, C. & St Pierre, Y. Dendritic cells prevent radiation-induced thymic lymphoma. Leukemia 10, 1639-1647 (1996).
3. Shin, S. C., Kang, Y. M. & Kim, H. S. Life span and thymic lymphoma incidence in high-and low-dose-rate irradiated AKR/J mice and commonly expressed genes. Radiat Res 174, 341-346 (2010).
4. Fu, Z. et al. Expression changes of ERK1/2, STAT3 and SHP-2 in bone marrow cells from gamma-ray induced leukemia mice. J Radiat Res 47, 121-130 (2006).
5. Liu, C. et al. MiR-21 plays an important role in radiation induced carcinogenesis in BALB/c mice by directly targeting the tumor suppressor gene Big-h3. International journal of biological sciences 7, 347-363 (2011).
6. Steinman, R. M. The dendritic cell system and its role in immunogenicity. Annual review of immunology 9, 271-296 (1991).
7. Steinman, R. M. & Banchereau, J. Taking dendritic cells into medicine. Nature 449, 419-426 (2007).
8. Palucka, K. & Banchereau, J. Cancer immunotherapy via dendritic cells. Nat Rev Cancer 12, 265-277 (2012).
9. Banchereau, J. & Palucka, A. K. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 5, 296-306 (2005).
10. Gabrilovich, D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol 4, 941-952 (2004).
11. Ma, Y., Shurin, G. V., Peiyuan, Z. & Shurin, M. R. Dendritic cells in the cancer microenvironment. J Cancer 4, 36-44 (2013).
12. Liu, Q., Zhang, C., Sun, A., Zheng, Y., Wang, L. & Cao, X. Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. Journal of immunology 182, 6207-6216 (2009).
13. Goldberg, I. J., Eckel, R. H. & Abumrad, N. A. Regulation of fatty acid uptake into tissues: lipoprotein lipase-and CD36-mediated pathways. J Lipid Res 50 Suppl, S86-90 (2009).
14. Yang, R. et al. RNAi-mediated germline knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice. Int J Obes (Lond) 35, 217-225 (2011).
15. Herber, D. L. et al. Lipid accumulation and dendritic cell dysfunction in cancer. Nat Med 16, 880-886 (2010).
16. Sanderson, P., MacPherson, G. G., Jenkins, C. H. & Calder, P. C. Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells. J Leukoc Biol 62, 771-777 (1997).
17. Aliberti, J., Hieny, S., Reis e Sousa, C., Serhan, C. N. & Sher, A. Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat Immunol 3, 76-82 (2002).
18. Weatherill, A. R., Lee, J. Y., Zhao, L., Lemay, D. G., Youn, H. S. & Hwang, D. H. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. J Immunol 174, 5390-5397 (2005).
19. Shamshiev, A. T., Ampenberger, F., Ernst, B., Rohrer, L., Marsland, B. J. & Kopf, M. Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alphanegative dendritic cells and protective Th1 type immunity. J Exp Med 204, 441-452 (2007).
20. Angeli, V. et al. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21, 561-574 (2004).
21. Yonejima, Y., Ushida, K. & Mori, Y. Effect of Lactic Acid Bacteria on Lipid Metabolism and Fat Synthesis in Mice Fed aHigh-fat Diet. Biosci Microbiota Food Health 32, 51-58 (2013).
22. Fu, Z. et al. Expression changes of ERK1/2, STAT3 and SHP-2 in bone marrow cells from gamma-ray induced leukemia mice. J Radiat Res (Tokyo) 47, 121-130 (2006).
23. Liu, C. et al. Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis. Int J Biol Sci 7, 168-179 (2011).
24. Liu, C. et al. A critical role of toll-like receptor 4 (TLR4) and its' in vivo ligands in basal radio-resistance. Cell death & disease 4, e649 (2013).
25. Hou, J. et al. Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 19, 232-243 (2011).
26. Tuck, M. K. et al. Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group. J Proteome Res 8, 113-117 (2009).
27. Inaba, K. et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colonystimulating factor. J Exp Med 176, 1693-1702 (1992).
28. Halvorson, D. L. & McCune, S. A. Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid. Lipids 19, 851-856 (1984).
29. de Winther, M. P., van Dijk, K. W., Havekes, L. M. & Hofker, M. H. Macrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis. Arterioscler Thromb Vasc Biol 20, 290-297 (2000).
30. Peiser, L., Mukhopadhyay, S. & Gordon, S. Scavenger receptors in innate immunity. Curr Opin Immunol 14, 123-128 (2002).
31. Husemann, J., Loike, J. D., Anankov, R., Febbraio, M. &Silverstein, S. C. Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia 40, 195-205 (2002).
32. Hill-Baskin, A. E. et al. Diet-induced hepatocellular carcinoma in genetically predisposed mice. Hum Mol Genet 18, 2975-2988 (2009).
33. Apetoh, L. et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 13, 1050-1059 (2007).