Microsatellite instability, disease-free survival and role of tumour infiltrating lymphocytes (Invited editorial on 'Predictors of disease-free survival in colorectal cancer with microsatellite instability: An AGEO multicenter study')

European Journal of Cancer

Volumn 51, Issue 8, 2015, Pages 922-924

  Lynch, Henry T ^a   Lanspa, Stephen J ^a   Snyder, Carrie L ^a   Drescher, Kristen M ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; CD3 ANTIGEN; CD8 ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER DIAGNOSIS; CANCER IMMUNOTHERAPY; CANCER PATIENT; CANCER RECURRENCE; CANCER RISK; CANCER SURGERY; CANCER SURVIVAL; CD4+ T LYMPHOCYTE; CELL DENSITY; COLON RESECTION; COLORECTAL CANCER; COLORECTAL POLYP; COWDEN SYNDROME; CPG ISLAND; DIFFERENTIAL DIAGNOSIS; DISEASE FREE SURVIVAL; EDITORIAL; FAMILIAL COLON POLYPOSIS; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INTESTINE OBSTRUCTION; MEDULLARY CARCINOMA; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MOLECULAR GENETICS; MULTICENTER STUDY (TOPIC); PATHOLOGIST; PEUTZ JEGHERS SYNDROME; PHENOTYPE; PRIORITY JOURNAL; RECURRENCE RISK; RECURRENT DISEASE; RETROSPECTIVE STUDY; TH17 CELL; TREATMENT RESPONSE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; COLORECTAL NEOPLASMS; FEMALE; GENETICS; MALE;

COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MICROSATELLITE INSTABILITY;

EID: 84928951519     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2015.03.012     Document Type: Note

References (20)

1. C.R. Boland, and A. Goel Microsatellite instability in colorectal cancer Gastroenterology 138 2010 2073 2087
2. F.A. Sinicrope, and D.J. Sargent Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications Clin Cancer Res 18 2012 1506 1512
3. J.M. Carethers, D.P. Chauhan, D. Fink, S. Nebel, R. Bresalier, and S.B. Howell Mismatch repair proficiency and in vitro response to 5-fluorouracil Gastroenterology 117 1999 123 131
4. C.M. Ribic, D.J. Sargent, M.J. Moore, S.N. Thibodeau, A.J. French, and R.M. Goldberg Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer N Engl J Med 349 2003 247 257
5. Tougeron D, Sickersen G, Mouillet G, Zaanan A, Trouilloud I, Coriat R, et al. Predictors of disease-free survival in colorectal cancer with microsatellite instability: an AGEO multicenter study. Eur J Cancer. in press (this issue).
6. D. Tougeron, P. Maby, N. Elie, E. Fauquembergue, F. Le Pessot, and M. Cornic Regulatory T lymphocytes are associated with less aggressive histologic features in microsatellite-unstable colorectal cancers PLoS One 8 2013 e61001
7. T.C. Smyrk, P. Watson, K. Kaul, and H.T. Lynch Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal cancer Cancer 91 2001 2417 2422
8. R. Dolcetti, A. Viel, C. Doglioni, A. Russo, M. Guidoboni, and E. Capozzi High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability Am J Pathol 154 1999 1805 1813
9. E. Yakirevich, O. Ben Izhak, G. Rennert, Z.G. Kovacs, and M.B. Resnick Cytotoxic phenotype of tumor infiltrating lymphocytes in medullary carcinoma of the breast Mod Pathol 12 1999 1050 1056
10. K.M. Drescher, P. Sharma, P. Watson, Z. Gatalica, S.N. Thibodeau, and H.T. Lynch Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer Fam Cancer 8 2009 231 239
11. K.M. Drescher, P. Sharma, and H.T. Lynch Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch syndrome patients Clin Dev Immunol 2010 2010 Article ID 170432
12. K.M. Drescher, and H.T. Lynch Tumor infiltrating lymphocytes (TILs)::lessons learned in 30 years of study Clin Appl Immunol Rev 5 2005 149 166
13. S. Le Gouvello, S. Bastuji-Garin, N. Aloulou, H. Mansour, M.T. Chaumette, and F. Berrehar High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas Gut 57 2008 772 779
14. M. Tosolini, A. Kirilovsky, B. Mlecnik, T. Fredriksen, S. Mauger, and G. Bindea Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer Cancer Res 71 2011 1263 1271
15. K. Nosho, Y. Baba, N. Tanaka, K. Shima, M. Hayashi, and J.A. Meyerhardt Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review J Pathol 222 2010 350 366
16. D. Tougeron, É. Fauquembergue, and J.B. Latouche Immunotherapy for colorectal cancer Bull Cancer 100 2013 871 885
17. M.O. Frank, J. Kaufman, S. Parveen, N.E. Blachère, D.E. Orange, and R.B. Darnell Dendritic cell vaccines containing lymphocytes produce improved immunogenicity in patients with cancer J Trans Med 12 2014 338
18. M.A. Michelin, D.R. Abdalla, A.A.R. Aleixo, and E.F.C. Murta Peripheral helper lymphocytes produce interleukin 12 in cancer patients Clin Med Insights Oncol 7 2013 75 81
19. S. Parry, A.K. Win, B. Parry, F.A. Macrae, L.C. Gurrin, and J.M. Church Metachronous colorectal cancer risk for mismatch repair gene mutation carriers: the advantage of more extensive colon surgery Gut 60 2011 950 957
20. S. Syngal, R.E. Brand, J.M. Church, F.M. Giardiello, H.L. Hampel, and R.W. Burt ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes Am J Gastroenterol 110 2015 223 262