Stimulating the aberrant brain: Evidence for increased cortical hyperexcitability from a transcranial direct current stimulation (tDCS) study of individuals predisposed to anomalous perceptions

Cortex

Volumn 69, Issue , 2015, Pages 1-13

  Braithwaite, Jason J ^a   Mevorach, Carmel ^a   Takahashi, Chie ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Brain stimulation; Cortical hyperexcitability; Hallucinations; Pattern glare; TDCS

Indexed keywords

ADULT; ALTERNATING CURRENT; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; CONTROLLED STUDY; CORRELATION COEFFICIENT; CORTICAL HYPEREXCITABILITY; DISEASE PREDISPOSITION; ELECTRIC RESISTANCE; EVOKED VISUAL RESPONSE; FEMALE; GLARE; HALLUCINATION; HUMAN; MAJOR CLINICAL STUDY; MEMBRANE STEADY POTENTIAL; NERVE EXCITABILITY; POSTGRADUATE STUDENT; QUANTITATIVE ANALYSIS; RIGHT HANDEDNESS; SKIN SENSATION; STRIATE CORTEX; TRANSCRANIAL DIRECT CURRENT STIMULATION; VISUAL FIELD; VISUAL STIMULATION; ADOLESCENT; BRAIN CORTEX; PATHOPHYSIOLOGY; PERCEPTION DISORDER; YOUNG ADULT;

ADOLESCENT; ADULT; CEREBRAL CORTEX; FEMALE; HALLUCINATIONS; HUMANS; PERCEPTUAL DISORDERS; TRANSCRANIAL DIRECT CURRENT STIMULATION; YOUNG ADULT;

EID: 84928942953     PISSN: 00109452     EISSN: 19738102     Source Type: Journal    
DOI: 10.1016/j.cortex.2015.03.023     Document Type: Article

References (94)

1. Accornero N., Li Voti P., La Riccia M., Gregori B. Visual evoked potentials modulation during direct current cortical polarization. Experimental Brain Research 2007, 178(2):261-266. 10.1007/s00221-006-0733-y.
2. Aggugia M., Zibetti M., Febbraro A., Mutani R. Transcranial magnetic stimulation in migraine with aura: further evidence of occipital cortex hyperexcitability. Cephalalgia 1999, 19:465.
3. Aleman A., Larøi F. Hallucinations: The science of idiosyncratic perception 2008, American Psychological Association, Washington, DC, US.
4. Allen P., Larøi F., McGuire P.K., Aleman A. The hallucinating brain: a review of structural and functional neuroimaging studies of hallucinations. Neuroscience and Biobehavioral Reviews 2008, 32(1):175-191. 10.1016/j.neubiorev.2007.07.012.
5. Antal A., Kincses T.Z., Nitsche M.A., Bartfai O., Paulus W. Excitability changes induced in the human primary visual cortex by transcranial direct current stimulation: direct electrophysiological evidence. Investigative Ophthalmology & Visual Science 2004, 45(2):702-707.
6. Antal A., Kincses T.Z., Nitsche M.A., Paulus W. Manipulation of phosphene thresholds by transcranial direct current stimulation in man. Experimental Brain Research 2003, 150(3):375-378. 10.1007/s00221-003-1459-8.
7. Antal A., Nitsche M.A., Paulus W. Transcranial direct current stimulation and the visual cortex. Brain Research Bulletin 2006, 68(6):459-463. 10.1016/j.brainresbull.2005.10.006.
8. Antal A., Paulus W. Transcranial direct current stimulation and visual perception. Perception 2008, 37(3):367-374. 10.1068/p5872.
9. Antal A., Paulus W., Nitsche M.A. Electrical stimulation and visual network plasticity. Restorative Neurology and Neuroscience 2011, 29(6):365-374. 10.3233/RNN-2011-0609.
10. Antal A., Terney D., Poreisz C., Paulus W. Towards unravelling task-related modulations of neuroplastic changes induced in the human motor cortex. European Journal of Neuroscience 2007, 26(9):2687-2691. 10.1111/j.1460-9568.2007.05896.x.
11. Aurora S.K., Ahmed B.K., Welch K.M., Bhardhwaj P., Ramadan N.M. Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine. Neurology 1998, 50(4):1111-1114.
12. Aurora S.K., Cao Y., Bowyer S.M., Welch K.M. The occipital cortex is hyperexcitable in migraine: experimental evidence. Headache 1999, 39(7):469-476. 10.1046/j.1526-4610.1999.3907469.x.
13. Aurora S.K., Welch K.M. Migraine: imaging the aura. Current Opinion in Neurology 2000, 13(3):273-276.
14. Aurora S.K., Welch K.M., Al-Sayed F. The threshold for phosphenes is lower in migraine. Cephalalgia 2003, 23(4):258-263.
15. Aurora S.K., Wilkinson F. The brain is hyperexcitable in migraine. Cephalalgia 2007, 27(12):1442-1453.
16. Batsikadze G., Moliadze V., Paulus W., Kuo M.-F., Nitsche M.A. Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans. Journal of Physiology 2013, 591(7):1987-2000.
17. Beasley I.G., Davies L.N. Susceptibility to pattern glare following stroke. Journal of Neurology 2012, 259(9):1832-1839. 10.1007/s00415-012-6418-5.
18. Bell V., Halligan P.W., Ellis H.D. The Cardiff Anomalous Perceptions Scale (CAPS): a new validated measure of anomalous perceptual experience. Schizophrenia Bulletin 2006, 32(2):366-377.
19. Bell V., Halligan P.W., Pugh K., Freeman D. Correlates of perceptual distortions in clinical and non-clinical populations using the Cardiff Anomalous Perceptions Scale (CAPS): associations with anxiety and depression and a revalidation using a representative population sample. Psychiatry Research 2011, 189(3):451-457. 10.1016/j.psychres.2011.05.025.
20. Bentall R.P. The illusion of reality: a review and integration of psychological research on hallucinations. Psychological Bulletin 1990, 107(10):82-95.
21. Bien C.G., Benninger F.O., Urbach H., Schramm J., Kurthen M., Elger C.E. Localizing value of epileptic visual auras. Brain 2000, 123(2):244-253.
22. Braithwaite J.J., Broglia E., Bagshaw A.P., Wilkins A.J. Evidence for elevated cortical hyperexcitability and its association with out-of-body experience in the non-clinical population: new findings form a pattern-glare task. Cortex 2013, 49(3):793-805. 10.1016/j.cortex.2011.11.013.
23. Braithwaite J.J., Broglia E., Brincat O., Stapley L., Wilkins A.J., Takahashi C. Signs of increased cortical hyperexcitability selectively associated with spontaneous anomalous bodily experiences in a nonclinical population. Cognitive Neuropsychiatry 2013, 18(6):549-573. 10.1080/13546805.2013.768176.
24. Braithwaite J.J., Broglia E., Watson D.G. Autonomic emotional responses to the induction of the rubber-hand illusion in those that report anomalous bodily experiences: evidence for specific psychophysiological components associated with illusory body representations. Journal of Experimental Psychology Human Perception and Performance 2014, 40(3):1131-1145.
25. Braithwaite J.J., Hulleman J., Samson D., Apperly I. Cognitive correlates of the spontaneous out-of-body experience in the psychologically normal population: evidence for a role of temporal-lobe disturbance, body-distortion processing, and impairments in own- body transformations. Cortex 2011, 47(7):839-853. 10.1016/j.cortex.2010.05.002.
26. Braun C.M., Dumont M., Duval J., Hamel-Hébert I., Godbout L. Brain modules of hallucination: an analysis of multiple patients with brain lesions. Journal of Psychiatry & Neuroscience 2003, 28(6):432-449.
27. Bressloff P.C., Cowan J.D., Golubitsky M., Thomas P.J., Wiener M.C. Geometric visual hallucinations, Euclidean symmetry and the functional architecture of striate cortex. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 2001, 356(1407):299-330. 10.1098/rstb.2000.0769.
28. Bressloff P.C., Cowan J.D., Golubitsky M., Thomas P.J., Wiener M.C. What geometric visual hallucinations tell us about the visual cortex. Neural Computation 2002, 14(3):473-491.
29. Chadaide Z., Arlt S., Antal A., Nitsche M.A., Lang N., Paulus W. Transcranial direct current stimulation reveals inhibitory deficiency in migraine. Cephalalgia 2007, 27(7):833-839. 10.1111/j.1468-2982.2007.01337.x.
30. Collerton D., Perry E., McKeith I. Why people see things that are not there: a novel perception and attention deficit model for recurrent complex visual hallucinations. Behavioral and Brain Sciences 2005, 28(6):737-794.
31. Coutts L.V., Cooper C.E., Elwell C.E., Wilkins A.J. Time course of the haemodynamic response to visual stimulation in migraine, measured using near-infrared spectroscopy. Cephalalgia 2012, 32(8):621-629. 10.1177/0333102412444474.
32. Evans B.J. The need for optometric investigation in suspected Meares-Irlen syndrome or visual stress. Ophthalmic & Physiological Optics 2005, 25(4):363-370. 10.1111/j.1475-1313.2005.00289.x.
33. Evans B.J., Busby A., Jeanes R., Wilkins A.J. Optometric correlates of Meares-Irlen syndrome: a matched group study. Ophthalmic Physiological Optics 1995, 15(5):481-497. 10.1046/j.1475-1313.1995.9500063j.x.
34. Evans B.J., Drasdo N. Tinted lenses and related therapies for learning disabilities - a review. Ophthalmic and Physiological Optics 1991, 11(3):206-217. 10.1111/j.1475-1313.1991.tb00535.x.
35. Evans B.J., Stevenson S.J. The pattern glare test: a review and determination of normative values. Ophthalmic and Physiological Optics 2008, 28(4):295-309. 10.1111/j.1475-1313.2008.00578.x.
36. Feinberg T.E., Keenan J.P. Where in the brain is the self?. Consciousness and Cognition 2005, 14(4):661-678. 10.1016/j.concog.2005.01.002.
37. Ffytche D.H., Howard R.J. The perceptual consequences of visual loss: 'positive' pathologies of vision. Brain 1999, 122(7):1247-1260. 10.1093/brain/122.7.1247.
38. Ffytche D.H., Howard R.J., Brammer M.J., David A., Woodruff P., Williams S. The anatomy of conscious vision: an fMRI study of visual hallucinations. Nature Neuroscience 1998, 1(8):738-742.
39. Friedman D.I., De ver Dye T. Migraine and the environment. Headache 2009, 49(6):941-952. 10.1111/j.1526-4610.2009.01443.x.
40. Galea J.M., Jayaram G., Ajagbe L., Celnik P. Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. Journal of Neuroscience 2009, 29(28):9115-9122.
41. Gawel M., Connolly J.F., Rose F.C. Migraine patients exhibit abnormalities in the visual evoked potentials. Headache 1983, 23(2):49-52.
42. Gloor P. Role of the human limbic system in perception, memory, and affect: lessons from temporal lobe epilepsy. The limbic system: Functional organization and clinical disorders 1986, 159-169. Raven Press, New York, NY. B.K. Doane, K.E. Livingstone (Eds.).
43. Gloor P., Olivier A., Quesney L.F., Andermann F., Horowitz S. The role of the limbic system in experiential phenomena of temporal lobe epilepsy. Annals of Neurology 1982, 12(2):129-144.
44. Halgren E., Walter R.D., Cherlow D.G., Crandall P.H. Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala. Brain 1978, 101(1):83-117.
45. Harle D.E., Evans B.J. The optometric correlates of migraine. Ophthalmic Physiological Optics 2004, 24(5):369-383.
46. Hollis J., Allen P.M. Screening for Meares-Irlen sensitivity in adults: can assessment methods predict changes in reading speed?. Ophthalmic & Physiological Optics 2006, 26(6):566-571. 10.1111/j.1475-1313.2006.00401.x.
47. Huang J., Cooper T.G., Satana D., Kaufman D.I., Cao Y. Visual distortion provoked by a stimulus in migraine associated with hyperneuronal activity. Headache 2003, 43(6):664-671. 10.1046/j.1526-4610.2003.03110.x.
48. Huang J., Zong X., Wilkins A., Jenkins B., Bozoki A., Cao Y. fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine. Cephalalgia 2011, 31(8):925-936. 10.1177/0333102411409076.
49. Jacobson L., Koslowsky M., Lavidor M. tDCS polarity effects in motor and cognitive domains: a meta-analytical review. Experimental Brain Research 2012, 216(1):1-10. 10.1007/s00221-011-2891-9.
50. Johns L.C., van Os J. The continuity of psychotic experiences in the general population. Clinical Psychology Review 2001, 21(8):1125-1141.
51. Keeser D., Meindl T., Bor J., Palm U., Pogarell O., Mulert C., et al. Prefrontal transcranial direct current stimulation changes connectivity of resting-state networks during fMRI. Journal of Neuroscience 2011, 31(43):15284-15293. 10.1523/JNEUROSCI.0542-11.2011.
52. Lopez-Rodrigo A.M., Paino Pineiro M.M., Martinez Suarez P.C., Caro M.I., Lemos Giraldez S. Hallucinations in a normal population: imagery and personality influences. Psychology in Spain 1997, 1(1):10-16.
53. Ludlow A., Wilkins A., Heaton P. The effect of coloured overlays on reading ability in children with Autism. Journal of Autism and Developmental Disorders 2006, 36(4):507-516.
54. Makarec K., Persinger M.A. Electroencephalographic correlates of temporal lobe signs and imaginings. Perceptual and Motor Skills 1987, 64(3):1124-1126.
55. Makarec K., Persinger M.A. Electroencephalographic validation of a temporal lobe signs inventory in a normalpopulation. Journal of Research in Personality 1990, 24:323-337.
56. Manford M., Andermann F. Complex visual hallucinations. Clinical and neurobiological insights. Brain 1998, 121(10):1819-1840.
57. Marcus D.A., Soso M.J. Migraine and stripe-induced visual discomfort. Archives of Neurology 1989, 46(10):1129-1132.
58. McCreery C., Claridge G. Healthy schizotypy: the case of out-of-body experiences. Personality and Individual Differences 2002, 32:141-154.
59. Meehl P.E. Schizotaxia, schizotypy, schizophrenia. American Psychologist 1962, 17:827-838.
60. Miranda P.C., Mekonnen A., Salvador R., Ruffini G. The electric field in the cortex during transcranial current stimulation. NeuroImage 2013, 70:48-58. 10.1016/j.neuroimage.2012.12.034.
61. Neppe V.M. The psychology of déjà vu: Have I been here before? 1983, Witwatersrand University Press, Johnnesburg.
62. Nitsche M.A., Cohen L.G., Wassermann E.M., Priori A., Lang N., Antal A., et al. Transcranial direct current stimulation: state of the art 2008. Brain Stimulation 2008, 1:206-223.
63. Nitsche M.A., Doemkes S., Karakose T., Antal A., Libetanz D., Lang N., et al. Shaping the effects of transcranial direct current stimulation of the human motor cortex. Journal of Neurophysiology 2007, 97:3109-3117.
64. Nitsche M.A., Liebetanz D., Lang N., Antal A., Tergau F., Paulus W. Safety criteria for transcranial direct current stimulation (tDCS) in humans. Clinical Neurophysiology 2003, 114(11):2220-2222. 10.1016/S1388-2457(03)00235-9.
65. Nitsche M.A., Paulus W. Transcranial direct current stimulation - update 2011. Restorative Neurology and Neuroscience 2011, 29(6):463-492.
66. Nulty D., Wilkins A.J., Williams J.M. Mood, pattern sensitivity and headache: a longitudinal study. Psychological Medicine 1987, 17(3):705-713.
67. van Os J., Hanssen M., Bijl R.V., Ravelli A. Strauss (1969) revisited: a psychosis continuum in the general population?. Schizophrenia Research 2000, 45(1-2):11-20.
68. Palmer J.E., Chronicle E.P., Rolan P., Mulleners W.M. Cortical hyperexcitability is cortical under-inhibition: evidence from a novel functional test of migraine patients. Cephalalgia 2000, 20(6):525-532.
69. Panayiotopoulos C.P. Elementary visual hallucinations in migraine and epilepsy. Journal of Neurology, Neurosurgery & Psychiatry 1994, 57(11):1371-1374.
70. Panayiotopoulos C.P. Visual phenomena and headache in occipital epilepsy: a review, a systematic study and differentiation from migraine. Epileptic Disorders 1999, 1(4):205-216.
71. Peña-Gómez C., Sala-Lonch R., Junqué C., Clemente I.C., Vidal D., Bargalló N., et al. Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI. Brain Stimulation 2012, 5(3):252-263. 10.1016/j.brs.2011.08.006.
72. Penfield W. The twenty-nineth Maudsley lecture: the role of the temporal cortex in certain psychical phenomena. Journal of Mental Science 1955, 101(424):451-465.
73. Penfield W., Perot P. The brain's record of auditory and visual experience. A final summary and discussion. Brain 1963, 86. 595-696.
74. Persinger M.A. The neuropsychiatry of paranormal experiences. Journal of Neuropsychiatry & Clinical Neuroscience 2001, 13(4):515-524.
75. Persinger M.A., Koren S.A. Experiences of spiritual visitation and impregnation: potential induction by frequency-modulated transients from an adjacent clock. Perception and Motor Skills 2001, 92(1):35-36.
76. Persinger M.A., Makarec K. Temporal lobe epileptic signs and correlative behaviors displayed by normal populations. Journal of General Psychology 1986, 114:179-195.
77. Persinger M.A., Makarec K. Complex partial epileptic-like signs as a continuum from normals to epileptics: normative data and clinical populations. Journal of Clinical Psychology 1993, 49(1):33-45.
78. Poreisz C., Boros K., Antal A., Paulus W. Safety aspectsof transcranial direct current stimulation concerninghealthy subjects and patients. Brain Research Bulletin 2007, 72(4-6):208-214. 10.1016/j.brainresbull.2007.01.004.
79. Romero Lauro L.J., Rosanova M., Mattavelli G., Convento S., Pisoni A., Opitz A., et al. TDCS increases cortical excitability: direct evidence from TMS-EEG. Cortex 2014, 58:99-111. 10.1016/j.cortex.2014.05.003.
80. Schwartzman D., Maravic K., Kranczioch C., Barnes J. Altered early visual processing components in hallucination-prone individuals. NeuroReport 2008, 19(9):933-937. 10.1097/WNR.0b013e328301a640.
81. Serper M., Dill C.A., Chang N., Kot T., Elliot J. Factorial structure and classification of hallucinations: continuity of experience in psychotic and normal individuals. Journal of Nervous and Mental Disease 2005, 193(4):265-272.
82. Siegel R.K. Hallucinations. Scientific American 1977, 237(4):132-140.
83. Sierra M. Depersonalization: A new look at a neglected syndrome 2009, Cambridge University Press, Cambridge.
84. Spiegel D.P., Byblow W.D., Hess R.F., Thompson B. Anodal transcranial direct current stimulation transiently improves contrast sensitivity and normalizes visual cortex activation in individual with amblyopia. Neurorehabilitation and Neural Repair 2013, 27(8):760-769.
85. Spiegel D.P., Hansen B.C., Byblow W.D., Thompson B. Anodal transcranial direct current stimulation reduces psychophisically measured surround suppression in the human visual cortex. PLoS One 2012, 7(5):e36220. 1-9. 10.1371/journal.pone.0036220.
86. Taylor I., Scheffer I.E., Berkovic S.F. Occipital epilepsies: identification of specific and newly recognized syndromes. Brain 2003, 126(4):753-769.
87. Vallar G., Bolognini N. Behavioural facilitation following brain stimulation: implications for neurorehabilitation. Neuropsychological Rehabilitation 2011, 21(5):618-649. 10.1080/09602011.2011.574050.
88. Viganò A., D'Elia T.S., Sava S.L., Auvé M., De Pasqua V., Colosimo A., et al. Transcranial Direct Stimulation (tDCS) of the visual cortex: a proof-of-concept study based on interictal electrophysiological abnormalities in migraine. Journal of Headache and Pain 2013, 14(1):23. 10.1186/1129-2377-14-2.
89. Wassermann E.M. Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. Electroencephalography and Clinical Neurophysiology 1998, 108(1):1-16.
90. Wilkins A.J. What is visual discomfort?. Trends in Neurosciences 1986, 9:343-346.
91. Wilkins A.J. Visual stress 1995, Oxford University Press, New York, NY.
92. Wilkins A.J., Nimmo-Smith I., Tait A., McManus C., Della Salla S., Tilley A., et al. A neurological basis for visual discomfort. Brain 1984, 107(4):989-1017.
93. Wilkins A.J., Tang P., Irabor J., Baningham L., Coutts L. Cortical haemodynamic response to coloured gratings. Perception 2008, 37:144.
94. Young W.B., Oshinsky M.L., Shechter A.L., Gebeline-Myers C., Bradley K.C., Wassermann E.M. Consecutive transcranial magnetic stimulation: phosphene thresholds in migraineurs and controls. Headache 2004, 44(2):131-135.